Impaired oxygen delivery to muscle in chronic fatigue syndrome

1999 ◽  
Vol 97 (5) ◽  
pp. 603-608 ◽  
Author(s):  
Kevin K. MCCULLY ◽  
Benjamin H. NATELSON
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Time Constant ◽  
Oxidative Metabolism ◽  
Oxygen Delivery ◽  
Specific Effect ◽  
Chronic Fatigue ◽  
Medial Gastrocnemius ◽  
Resonance Spectroscopy ◽  
Activity Levels ◽  
Fatigue Syndrome

The purpose of this study was to determine if chronic fatigue syndrome (CFS) is associated with reduced oxygen delivery to muscles. Patients with CFS according to CDC (Center for Disease Control) criteria (n = 20) were compared with normal sedentary subjects (n = 12). Muscle oxygen delivery was measured as the rate of post-exercise and post-ischaemia oxygen-haem resaturation. Oxygen-haem resaturation was measured in the medial gastrocnemius muscle using continuous-wavelength near-IR spectroscopy. Phosphocreatine resynthesis was measured simultaneously using 31P magnetic resonance spectroscopy. The time constant of oxygen delivery was significantly reduced in CFS patients after exercise (46.5±16 s; mean±S.D.) compared with that in controls (29.4±6.9 s). The time constant of oxygen delivery was also reduced (20.0±12 s) compared with controls (12.0±2.8 s) after cuff ischaemia. Oxidative metabolism was also reduced by 20% in CFS patients, and a significant correlation was found between oxidative metabolism and recovery of oxygen delivery. In conclusion, oxygen delivery was reduced in CFS patients compared with that in sedentary controls. This result is consistent with previous studies showing abnormal autonomic control of blood flow. Reduced oxidative delivery in CFS patients could be specifically related to CFS, or could be a non-specific effect of reduced activity levels in these patients. While these results suggest that reduced oxygen delivery could result in reduced oxidative metabolism and muscle fatigue, further studies will be needed to address this issue.

scholarly journals Muscle metabolism with blood flow restriction in chronic fatigue syndrome

2004 ◽  
Vol 96 (3) ◽  
pp. 871-878 ◽  
Author(s):  
Kevin K. McCully ◽  
Sinclair Smith ◽  
Sheeva Rajaei ◽  
John S. Leigh ◽  
Benjamin H. Natelson
Keyword(s):  
Blood Flow ◽  
Chronic Fatigue Syndrome ◽  
Oxygen Saturation ◽  
Oxidative Metabolism ◽  
Muscle Blood Flow ◽  
Muscle Metabolism ◽  
Chronic Fatigue ◽  
Medial Gastrocnemius ◽  
Resonance Spectroscopy ◽  
Fatigue Syndrome

The purpose of this study was to determine whether chronic fatigue syndrome (CFS) is associated with reduced blood flow and muscle oxidative metabolism. Patients with CFS according to Centers for Disease Control criteria ( n = 19) were compared with normal sedentary subjects ( n = 11). Muscle blood flow was measured in the femoral artery with Doppler ultrasound after exercise. Muscle metabolism was measured in the medial gastrocnemius muscle with 31P-magnetic resonance spectroscopy. Muscle oxygen saturation and blood volume were measured using near-infrared spectroscopy. CFS and controls were not different in hyperemic blood flow or phosphocreatine recovery rate. Cuff pressures of 50, 60, 70, 80, and 90 mmHg were used to partially restrict blood flow during recovery. All pressures reduced blood flow and oxidative metabolism, with 90 mmHg reducing blood flow by 46% and oxidative metabolism by 30.7% in CFS patients. Hyperemic blood flow during partial cuff occlusion was significantly reduced in CFS patients ( P < 0.01), and recovery of oxygen saturation was slower ( P < 0.05). No differences were seen in the amount of reduction in metabolism with partially reduced blood flow. In conclusion, CFS patients showed evidence of reduced hyperemic flow and reduced oxygen delivery but no evidence that this impaired muscle metabolism. Thus CFS patients might have altered control of blood flow, but this is unlikely to influence muscle metabolism. Furthermore, abnormalities in muscle metabolism do not appear to be responsible for the CFS symptoms.

Blood flow and muscle metabolism in chronic fatigue syndrome

2003 ◽  
Vol 104 (6) ◽  
pp. 641-647 ◽  
Author(s):  
Kevin K. McCULLY ◽  
Sinclair SMITH ◽  
Sheeva RAJAEI ◽  
John S. LEIGH ◽  
Benjamin H. NATELSON
Keyword(s):  
Blood Flow ◽  
Chronic Fatigue Syndrome ◽  
Muscle Blood Flow ◽  
Muscle Metabolism ◽  
Chronic Fatigue ◽  
Medial Gastrocnemius ◽  
Resonance Spectroscopy ◽  
Muscle Oxygen ◽  
Fatigue Syndrome ◽  
Rate Of Recovery

The purpose of this study was to determine if chronic fatigue syndrome (CFS) is associated with reduced blood flow and oxidative delivery to skeletal muscle. Patients with CFS according to CDC (Center for Disease Control) criteria (n=19) were compared with normal sedentary subjects (n=11). Muscle blood flow was measured with Doppler ultrasound after cuff ischaemia and exercise. Muscle oxygen delivery was measured as the rate of post-exercise and post-ischaemic oxygen-haem resaturation. Oxygen-haem resaturation was measured in the medial gastrocnemius muscle using continuous wavelength near-IR spectroscopy. Muscle metabolism was measured using 31P magnetic resonance spectroscopy. CFS patients and controls were not different in the peak blood flow after cuff ischaemia, the rate of recovery of phosphocreatine after submaximal exercise, and the rate of recovery of oxygen saturation after cuff ischaemia. In conclusion, CFS patients showed no deficit in blood flow or oxidative metabolism. This suggests that CFS symptoms do not require abnormal peripheral function.

scholarly journals Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study

Diagnostics ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 41 ◽  
Author(s):  
Nacul ◽  
de Barros ◽  
Kingdon ◽  
Cliff ◽  
Clark ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Cross Sectional Study ◽  
Myalgic Encephalomyelitis ◽  
Activity Levels ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional ◽  
Fatigue Syndrome ◽  
Laboratory Test Results

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease presenting with extreme fatigue, post-exertional malaise, and other symptoms. In the absence of a diagnostic biomarker, ME/CFS is diagnosed clinically, although laboratory tests are routinely used to exclude alternative diagnoses. In this analytical cross-sectional study, we aimed to explore potential haematological and biochemical markers for ME/CFS, and disease severity. We reviewed laboratory test results from 272 people with ME/CFS and 136 healthy controls participating in the UK ME/CFS Biobank (UKMEB). After corrections for multiple comparisons, most results were within the normal range, but people with severe ME/CFS presented with lower median values (p < 0.001) of serum creatine kinase (CK; median = 54 U/L), compared to healthy controls (HCs; median = 101.5 U/L) and non-severe ME/CFS (median = 84 U/L). The differences in CK concentrations persisted after adjusting for sex, age, body mass index, muscle mass, disease duration, and activity levels (odds ratio (OR) for being a severe case = 0.05 (95% confidence interval (CI) = 0.02–0.15) compared to controls, and OR = 0.16 (95% CI = 0.07–0.40), compared to mild cases). This is the first report that serum CK concentrations are markedly reduced in severe ME/CFS, and these results suggest that serum CK merits further investigation as a biomarker for severe ME/CFS.

4-10-01 In vitro study of muscle oxidative metabolism in chronic fatigue syndrome

1997 ◽  
Vol 150 ◽  
pp. S225
Author(s):  
W. Behan ◽  
I. Holt ◽  
D. Kay ◽  
P. Moonie ◽  
P. Behan
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Oxidative Metabolism ◽  
In Vitro Study ◽  
Chronic Fatigue ◽  
Vitro Study ◽  
Fatigue Syndrome

Impaired oxygen delivery to muscle in chronic fatigue syndrome

1999 ◽  
Vol 97 (5) ◽  
pp. 603 ◽  
Author(s):  
Kevin K. MCCULLY ◽  
Benjamin H. NATELSON
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Oxygen Delivery ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

Premorbid Functioning, Welfare Issues and Ethics in Chronic Fatigue Syndrome

2003 ◽  
Vol 11 (3) ◽  
pp. 312-318
Author(s):  
Chris Cantor ◽  
Kerryn Neulinger
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Ethical Issues ◽  
Case Reports ◽  
Chronic Fatigue ◽  
Exercise Intolerance ◽  
Systematic Research ◽  
Activity Levels ◽  
Subjective Memory ◽  
Fatigue Syndrome ◽  
Premorbid Functioning

Objective: To assess former activity levels in chronic fatigue syndrome (CFS) subjects, identify differentiating variables and discuss ethical issues arising. Method: File review of 91 CFS patients from a private psychiatric practice, presenting multiple case reports, with limited case comparison data. Results: The CFS subjects appeared formerly more athletically inclined than controls. Other helpful differentiating variables included exercise intolerance, excessive need for sleep, hopefulness and subjective memory problems. Conclusions: Former exercise and other achievement levels warrant systematic research study and consideration in the assessment of CFS patients. Omissions of consideration of premorbid functioning in medicolegal evaluations raise ethical concerns.

scholarly journals Discriminating between chronic fatigue syndrome and depression: a cognitive analysis

2001 ◽  
Vol 31 (3) ◽  
pp. 469-479 ◽  
Author(s):  
RONA MOSS-MORRIS ◽  
KEITH J. PETRIE
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Cognitive Distortions ◽  
Chronic Fatigue ◽  
Self Esteem ◽  
Activity Levels ◽  
Depressed Patients ◽  
Fatigue Syndrome ◽  
Cognitive Behavioural ◽  
Depressed Group ◽  
The Stability

Background. Chronic fatigue syndrome (CFS) and depression share a number of common symptoms and the majority of CFS patients meet lifetime criteria for depression. While cognitive factors seem key to the maintenance of CFS and depression, little is known about how the cognitive characteristics differ in the two conditions.Methods. Fifty-three CFS patients were compared with 20 depressed patients and 38 healthy controls on perceptions of their health, illness attributions, self-esteem, cognitive distortions of general and somatic events, symptoms of distress and coping. A 6 month follow-up was also conducted to determine the stability of these factors and to investigate whether CFS-related cognitions predict ongoing disability and fatigue in this disorder.Results. Between-group analyses confirmed that the depressed group was distinguished by low self-esteem, the propensity to make cognitive distortions across all situations, and to attribute their illness to psychological factors. In contrast, the CFS patients were characterized by low ratings of their current health status, a strong illness identity, external attributions for their illness, and distortions in thinking that were specific to somatic experiences. They were also more likely than depressed patients to cope with their illness by limiting stress and activity levels. These CFS-related cognitions and behaviours were associated with disability and fatigue 6 months later.Conclusions. CFS and depression can be distinguished by unique cognitive styles characteristic of each condition. The documented cognitive profile of the CFS patients provides support for the current cognitive behavioural models of the illness.

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