Articulation and Stress/Juncture Production Under Oral Anesthetization and Masking

1971 ◽  
Vol 14 (2) ◽  
pp. 271-282 ◽  
Author(s):  
Sylvia A. Gammon ◽  
Philip J. Smith ◽  
Raymond G. Daniloff ◽  
Chin W. Kim
Keyword(s):  
Feedback Control ◽  
Oral Cavity ◽  
White Noise ◽  
Speech Production ◽  
Local Anesthesia ◽  
The Other ◽  
Control Mechanisms ◽  
Combined Stress ◽  
Noise Masking ◽  
High Degree

Eight subjects, half of them naive and the other half aware of the purpose of the experiment, spoke 30 pairs of sentences involving the production of intricate stress/juncture patterns along with a passage containing all major consonant phonemes in English in various intraword positions. All subjects spoke all materials under: (1) normal conditions, (2) 110 dB re: 0.0002 ubar white noise masking, (3) extensive local anesthesia of the oral cavity, and (4) masking and anesthesia combined. Stress and juncture patterns were correctly produced despite all feedback disruption, and there was no difference between naive and aware subjects. Noise masking produced a decline in speech quality and a disruption of normal rhythm, both of which were even more seriously affected by anesthesia and anesthesia plus masking. There were no significant vowel misarticulations under any condition, but there was nearly a 20% rate of consonant misartiqulation under anesthesia and anesthesia and noise. Mis-articulation was most severe for fricatives and affricates in the labial and alveolar regions, presumably because these productions demand a high degree of precision of articulate shape and location and hence, intact feedback. Results are discussed in terms of feedback-control mechanisms for speech production.

Laterality Differences in the Auditory Feedback Control of Speech

1970 ◽  
Vol 13 (2) ◽  
pp. 298-303 ◽  
Author(s):  
James H. Abbs ◽  
Karl U. Smith
Keyword(s):  
Feedback Control ◽  
White Noise ◽  
Auditory Feedback ◽  
Speech Sound ◽  
Delayed Auditory Feedback ◽  
Noise Masking ◽  
Hybrid Computer ◽  
The Right ◽  
Auditory Feedback Control ◽  
Speech Identification

Proceeding from prior experimental evidence that better speech-sound identification most often occurs with right-ear presentation, an experiment was conducted to test for differences in speech production with right-ear and left-ear auditory feedback of one’s own speech. A hybrid-computer system and techniques of experimental programing were employed to control the intervals of aural delay. Presentation of delayed auditory feedback to the right ear during speech, with white noise masking the left ear, resulted in a significantly greater number of articulatory errors than did delayed feedback to the left ear with white noise masking the right ear. With a measure of total speaking time, however, similar differences between ears during delayed hearing were not found. The findings were interpreted as an indication of differences in aural function during auditory feedback control of speech. Such differences are consistent with aural laterality differences reported with speech identification.

Accidental Swallowing of Dental Implant: Complication of Transnasal Endoscopic Removal From Maxillary Sinus

2019 ◽  
Vol 45 (3) ◽  
pp. 219-222 ◽  
Author(s):  
Sung Ho Yoon ◽  
Seunggon Jung ◽  
Taegu Kang ◽  
Hyung Chae Yang
Keyword(s):  
Oral Cavity ◽  
Nasal Cavity ◽  
Maxillary Sinus ◽  
Dental Implants ◽  
Local Anesthesia ◽  
Dental Implant ◽  
The Other ◽  
Endoscopic Removal

Transnasal endoscopic removal of displaced dental implants in the maxillary sinus can be done easily under local anesthesia. However, very little is known regarding the precaution of this technique. In this report, we present the case of a 63-year-old man who visited the otolaryngologic department with a displaced dental implant in the maxillary sinus. Transnasal endoscopic removal of the displaced dental implant was planned and performed. However, the displaced dental implant was lost during removal. The implant was not seen in the other parts of the nasal cavity nor in the other parts of the oral cavity. Finally, radiographs revealed the presence of the dental implant at the level of the esophagus, although the patient did not notice anything because of local anesthesia. Thus, we conclude that operators should take into account the possibility of aspiration or swallowing of an implant through the posterior nasal aperture during the removal procedure. Precautions should be taken to avoid the possibility of implant aspiration or implant ingestion.

Orosensory Perception, Speech Production, and Deafness

1973 ◽  
Vol 16 (2) ◽  
pp. 257-266 ◽  
Author(s):  
Milo E. Bishop ◽  
Robert L. Ringel ◽  
Arthur S. House
Keyword(s):  
High School ◽  
Speech Production ◽  
Poor Performance ◽  
Normal Hearing ◽  
The Other ◽  
Functional Disorders ◽  
Form Discrimination ◽  
School Subjects ◽  
Oral Form ◽  
Similarities And Differences

The oral form-discrimination abilities of 18 orally educated and oriented deaf high school subjects were determined and compared to those of manually educated and oriented deaf subjects and normal-hearing subjects. The similarities and differences among the responses of the three groups were discussed and then compared to responses elicited from subjects with functional disorders of articulation. In general, the discrimination scores separated the manual deaf from the other two groups, particularly when differences in form shapes were involved in the test. The implications of the results for theories relating orosensory-discrimination abilities are discussed. It is postulated that, while a failure in oroperceptual functioning may lead to disorders of articulation, a failure to use the oral mechanism for speech activities, even in persons with normal orosensory capabilities, may result in poor performance on oroperceptual tasks.

Effect of Consonant-Vowel Ratio Modification on Amplitude Envelope Cues for Consonant Recognition

1991 ◽  
Vol 34 (2) ◽  
pp. 415-426 ◽  
Author(s):  
Richard L. Freyman ◽  
G. Patrick Nerbonne ◽  
Heather A. Cote
Keyword(s):  
White Noise ◽  
Intensity Ratio ◽  
Recognition Performance ◽  
Amplitude Envelope ◽  
Signal To Noise ◽  
Noise Masking ◽  
Spectral Cues ◽  
Consonant Recognition ◽  
Nonlinear Amplification ◽  
Speech Envelope

This investigation examined the degree to which modification of the consonant-vowel (C-V) intensity ratio affected consonant recognition under conditions in which listeners were forced to rely more heavily on waveform envelope cues than on spectral cues. The stimuli were 22 vowel-consonant-vowel utterances, which had been mixed at six different signal-to-noise ratios with white noise that had been modulated by the speech waveform envelope. The resulting waveforms preserved the gross speech envelope shape, but spectral cues were limited by the white-noise masking. In a second stimulus set, the consonant portion of each utterance was amplified by 10 dB. Sixteen subjects with normal hearing listened to the unmodified stimuli, and 16 listened to the amplified-consonant stimuli. Recognition performance was reduced in the amplified-consonant condition for some consonants, presumably because waveform envelope cues had been distorted. However, for other consonants, especially the voiced stops, consonant amplification improved recognition. Patterns of errors were altered for several consonant groups, including some that showed only small changes in recognition scores. The results indicate that when spectral cues are compromised, nonlinear amplification can alter waveform envelope cues for consonant recognition.

C-Terminal amino acid sequence of chicken pepsinogen and its homology with sequences of other acid proteases

1980 ◽  
Vol 45 (4) ◽  
pp. 1144-1154 ◽  
Author(s):  
Miroslav Baudyš ◽  
Helena Keilová ◽  
Vladimír Kostka
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
The Other ◽  
Terminal Sequence ◽  
Terminal Part ◽  
Terminal Amino Acid ◽  
Tryptic Peptides ◽  
Terminal Amino ◽  
High Degree ◽  
Terminal Amino Acid Sequence

To determine the primary structure of the C-terminal part of the molecule of chicken pepsinogen the tryptic, chymotryptic and thermolytic digest of the protein were investigated and peptides derived from this region were sought. These peptides permitted the following 21-residue C-terminal sequence to be determined: ...Ile-Arg-Glu-Tyr-Tyr-Val-Ile-Phe-Asp-Arg-Ala-Asn-Asn-Lys-Val-Gly-Leu-Ser-Pro-Leu-Ser.COOH. A comparison of this structure with the C-terminal sequential regions of the other acid proteases shows a high degree of homology between chicken pepsinogen and these proteases (e.g., the degree of homology with respect to hog pepsinogen and calf prochymosin is about 66%). Additional tryptic peptides, derived from the N-terminal part of the zymogen molecule whose amino acid sequence has been reported before, were also obtained in this study. This sequence was extended by two residues using an overlapping peptide. An ancillary result of this study was the isolation of tryptic peptides derived from other regions of the zymogen molecule.

Effect of Contralateral White Noise Masking on the Mismatch Negativity

1995 ◽  
Vol 24 (3) ◽  
pp. 165-173 ◽  
Author(s):  
Sirkku K. Salo ◽  
A. Heikki Lang ◽  
Altti J. Salmivalli
Keyword(s):  
White Noise ◽  
Mismatch Negativity ◽  
Noise Masking

scholarly journals Involvement of loop 5 lysine residues and the N-terminal β-hairpin of the ribotoxin hirsutellin A on its insecticidal activity

2016 ◽  
Vol 397 (2) ◽  
pp. 135-145 ◽  
Author(s):  
Miriam Olombrada ◽  
Lucía García-Ortega ◽  
Javier Lacadena ◽  
Mercedes Oñaderra ◽  
José G. Gavilanes ◽  
...  
Keyword(s):  
Active Sites ◽  
Structural Changes ◽  
The Other ◽  
Spatial Proximity ◽  
Ribonucleolytic Activity ◽  
The Family ◽  
Lysine Residues ◽  
Hirsutella Thompsonii ◽  
Close Spatial Proximity ◽  
High Degree

Abstract Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active sites. However, ribotoxins are larger, with a well-defined N-terminal β-hairpin, and display longer and positively charged unstructured loops. These structural differences account for their cytotoxic properties. Unexpectedly, the discovery of hirsutellin A (HtA), a ribotoxin produced by the invertebrate pathogen Hirsutella thompsonii, showed how it was possible to accommodate these features into a shorter amino acid sequence. Examination of HtA N-terminal β-hairpin reveals differences in terms of length, charge, and spatial distribution. Consequently, four different HtA mutants were prepared and characterized. One of them was the result of deleting this hairpin [Δ(8-15)] while the other three affected single Lys residues in its close spatial proximity (K115E, K118E, and K123E). The results obtained support the general conclusion that HtA active site would show a high degree of plasticity, being able to accommodate electrostatic and structural changes not suitable for the other previously known larger ribotoxins, as the variants described here only presented small differences in terms of ribonucleolytic activity and cytotoxicity against cultured insect cells.

Methylene. III. Gas phase reactions with 1-chloropropane

1969 ◽  
Vol 312 (1509) ◽  
pp. 141-161 ◽  
Keyword(s):  
Gas Phase ◽  
Rate Constants ◽  
Hydrogen Abstraction ◽  
The Other ◽  
Gas Phase Reactions ◽  
Other Hand ◽  
Chlorine Substituent ◽  
High Degree ◽  
Singlet Methylene

The work described in this and the following paper is a continuation of that in parts I and II, devoted to elucidation of the mechanism of the reactions of methylene with chloroalkanes, with particular reference to the reactivities of singlet and triplet methylene in abstraction and insertion processes. The products of the reaction between methylene, prepared by the photolysis of ketene, and 1-chloropropane have been identified and estimated and their dependence on reactant pressures, photolysing wavelength and presence of foreign gases (oxygen and carbon mon­oxide) has been investigated. Both insertion and abstraction mechanisms contribute significantly to the over-all reaction, insertion being relatively much more important than with chloroethane. This type of process appears to be confined to singlet methylene. If, as seems likely, there is no insertion into C—Cl bonds under our conditions (see part IV), insertion into C2—H and C3—H bonds occurs in statistical ratio, approximately. On the other hand, the chlorine substituent reduces the probability of insertion into C—H bonds in its vicinity. As in the chloroethane system, both species of methylene show a high degree of selectivity in their abstraction reactions. We find that k S Cl / k S H >7.7, k T Cl / k T H < 0.14, where the k ’s are rate constants for abstraction, and the super- and subscripts indicate the species of methylene and the type of atom abstracted, respectively. Triplet methylene is discriminating in hydrogen abstraction from 1-C 3 H 7 Cl, the overall rates for atoms attached to C1, C2, C3 being in the ratios 2.63:1:0.

A NEW APPROACH FOR INVESTIGATING HYPOTHALAMO-PITUITARY-GONADAL AND ADRENAL FEEDBACK CONTROL MECHANISMS: ACTIVE IMMUNIZATION WITH STEROIDS

1974 ◽  
Vol 76 (3) ◽  
pp. 556-569 ◽  
Author(s):  
E. Nieschlag ◽  
K. H. Usadel ◽  
H. K. Kley ◽  
U. Schwedes ◽  
K. Schöffling ◽  
...  
Keyword(s):  
Feedback Control ◽  
Leydig Cells ◽  
Positive Response ◽  
Active Immunization ◽  
Biologically Active ◽  
Control Group ◽  
Control Mechanisms ◽  
New Approach ◽  
Biological Neutralization ◽  
Group Serum

ABSTRACT A new method for the investigation of hypothalamo-pituitary-gonadal and adrenal feedback control mechanisms based on the biological neutralization of gonadal and adrenal steroids by active immunization is proposed. The regulatory influence of a given steroid in the feedback control is proved when reduction of the free, biologically active fraction of this steroid caused by antibody binding induces a positive response of the pituitary, thus effecting gonadal or adrenal hypertrophy and hyperfunction. The advantages and limitations of the new model are demonstrated by the effects of active immunization of rabbits with cortisol (F), aldosterone (Aldo), dehydroepiandrosterone (DHA), androstenedione (Δ4-A), testosterone (T), 5α-dihydrotestosterone (5α-DHT), 5β-DHT and oestradiol (E2). In the immunized animals and in a control group serum concentrations of total corticosteroids (TC), DHA, T, Δ4-A, E1, E2, LH and FSH, the percentage of binding of steroids in serum and the specificity of the antisera are determined. The testes are evaluated by histometry and the nuclear volume of the adrenocortical and Leydig cells is measured.

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