Introduction: Update on Pharmacological and Medical Management of Neurological Disorders

The coronavirus disease 2019 pandemic has disrupted the lives of whole communities and nations. The multinational multicenter National Institute of Neurological Disorders and Stroke Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial stroke prevention trial rapidly experienced the effects of the pandemic and had to temporarily suspend new enrollments and shift patient follow-up activities from in-person clinic visits to telephone contacts. There is an ethical obligation to the patients to protect their health while taking every feasible step to ensure that the goals of the trial are successfully met. Here, we describe the effects of the pandemic on the trial and steps that are being taken to mitigate the effects of the pandemic so that trial objectives can be met.

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Successful treatment of anorexia nervosa and alleviation of chronic Guillain Barré syndrome

Mental Illness ◽

10.4081/mi.2011.e1 ◽

2011 ◽

Vol 3 (1) ◽

pp. 1-2

Author(s):

Anneke Aden ◽

Thomas Stegemann ◽

Andreas Richterich

Keyword(s):

Eating Disorders ◽

Body Weight ◽

Anorexia Nervosa ◽

Eating Disorder ◽

Medical Management ◽

Neurological Disorders ◽

Guillain Barre Syndrome ◽

Guillain Barré Syndrome ◽

Locomotor Deficits ◽

Guillain Barré

Eating disorders do not typically occur in conjunction with specific neurological disorders. Only very few cases of Guillain-Barré-Syndrome (GBS) associated with eating disorders have been reported. The objective of this paper is to describe and discuss a case of anorexia nervosa and concomittant chronic GBS. We report on a course of medical management for a 15 year old female patient, who presented with acute neurological syndrome (GBS) which was followed by the onset of a severe eating disorder. The patient was diagnosed to have two different entities, with the association between the two remaining unclear. The mainstay of management was focused on the eating disorder. Using an integrative psychiatric therapy a significant improvement of the eating disorder was achieved. The patient's body weight was stabilised and the locomotor deficits improved. Though a significant somatic disorder was evident, it proved to be advantageous to primarily focus on the eating disorder, until it was under control. The possible correlations between the two distinct disorders are discussed.

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Three Tuberculosis Spondylitis Patients With Resistant Rifampicin From the Transpedicular Debridement Surgery Network

Malang Respiratory Journal ◽

10.21776/ub.mrj.2021.003.01.6 ◽

2021 ◽

Vol 3 (1) ◽

pp. 148-156

Author(s):

Yenny Widowati ◽

◽

Yani Sugiri ◽

Suryanti Pratiwi ◽

Syaifullah Asmiragani ◽

...

Keyword(s):

Quality Of Life ◽

Back Pain ◽

Physical Examination ◽

Medical Management ◽

Neurological Disorders ◽

Mortality And Morbidity ◽

Mdr Tb ◽

Rapid Tests ◽

Frequent Infection

Background: TB spondylitis is a disease that can cause neurological disorders, ranging from 1-2% of the total cases of tuberculosis where the most frequent infection is the spine followed by other large joints such as hips, knees and shoulders. The increase in TB spondylitis associated with MDR TB in 2015 showed 52% or about 32,000 incidences globally.Collaboration of individual alloy MDR TB therapy with surgery in TB spondylitis can reduce patient mortality and morbidity. Case: We report three cases of patients in 2017-2018 in Dr. Saiful Anwar with complaints of back pain and lumps in the back, from the results of anamnesa, physical examination and supporting examination of patients diagnosed with TB spondylitis, patients were given medical management, operative and rehabilitation. Conclusion: This case is interesting because from the results of Molecular Rapid Tests whose samples were obtained from a biopsy of the transpendicular debridement surgery tissue obtained the results of Resistant Rifampicin, all three patients received individualized OAT treatment, the development of the conditions of the three patients improved and quality of life improved.

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Ultrastructural Effects of Acute Kepone Treatment in Rats

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010009141x ◽

1976 ◽

Vol 34 ◽

pp. 286-287

Author(s):

Richard L. Klein ◽

Åsa K. Thureson-Klein ◽

Harihara M. Mehendale

Keyword(s):

Neurological Disorders ◽

Corn Oil ◽

Preliminary Investigation ◽

Reproductive Capacity ◽

Ultrastructural Changes ◽

Lipid Deposition ◽

Severe Toxicity ◽

Sprague Dawley ◽

Ether Anesthesia ◽

Sprague Dawley Rats

KeponeR (decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one) is an insecticide effective against ants and roaches. It can cause severe toxicity in fishes, birds, rodents and man. Prominent effects include hepatic lipid deposition and hypertrophy, impairment of reproductive capacity and neurological disorders. Mitochondrial oligomycin-sensitive Mg2+-ATPase is also inhibited. The present study is a preliminary investigation of tissue ultrastructural changes accompanying physiological signs of acute toxicity, which after two days treatment include: pronounced hypersensitivity and tremor, various degrees of anorexia and adipsia, and decreased weight gain.Three different series of adult male Sprague-Dawley rats (Charles River or CD-I) were treated by intubation with Kepone in corn oil at a dose of 50 mg per kg for 3 successive days or at 200 ppm in food for 8 days. After ether anesthesia, rats were immediately perfused via a cannula in the left ventricle with 4% p-formaldehyde and 0.5% glutaraldehyde in Millonig's phosphate buffer at pH 7.2 for 20-30 min at 22°C.

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Streptococcal pharyngitis in rural practice. Rational medical management

JAMA ◽

10.1001/jama.197.6.385 ◽

1966 ◽

Vol 197 (6) ◽

pp. 385-388 ◽

Cited By ~ 2

Author(s):

H. Jackson

Keyword(s):

Medical Management ◽

Streptococcal Pharyngitis ◽

Rural Practice

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Drug-Induced Movement Disorders

Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders ◽

10.1044/nnsld25.2.70 ◽

2015 ◽

Vol 25 (2) ◽

pp. 70-77

Author(s):

Amy Lustig ◽

Cesar Ruiz

Keyword(s):

Movement Disorders ◽

Medical Management ◽

Disease Process ◽

Underlying Disease ◽

Extrapyramidal Symptoms ◽

Drug Induced ◽

General Overview ◽

Management Approaches ◽

Broad Understanding ◽

Underlying Disease Process

The purpose of this article is to present a general overview of the features of drug-induced movement disorders (DIMDs) comprised by Parkinsonism and extrapyramidal symptoms. Speech-language pathologists (SLPs) who work with patients presenting with these issues must have a broad understanding of the underlying disease process. This article will provide a brief introduction to the neuropathophysiology of DIMDs, a discussion of the associated symptomatology, the pharmacology implicated in causing DIMDs, and the medical management approaches currently in use.

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