Comparison of the central nervous system effects produced by six H1-receptor antagonists

1996 ◽  
Vol 26 (9) ◽  
pp. 1092-1097 ◽  
Author(s):  
F. E. R. SIMONS ◽  
T. G. FRASER ◽  
J. D. REGGIN ◽  
K. J. SIMONS
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
H1 Receptor ◽  
Receptor Antagonists ◽  
The Central Nervous System

Central nervous system effects of H1-receptor antagonists in the elderly

1999 ◽  
Vol 82 (2) ◽  
pp. 157-160 ◽  
Author(s):  
F Estelle R Simons ◽  
Terry G Fraser ◽  
John Maher ◽  
Neelan Pillay ◽  
Keith J Simons
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
The Elderly ◽  
H1 Receptor ◽  
Receptor Antagonists

Involvement of the 5-HT3 receptor in CRH-induced defecation in rats

1998 ◽  
Vol 274 (5) ◽  
pp. G827-G831 ◽  
Author(s):  
Keiji Miyata ◽  
Hiroyuki Ito ◽  
Shin Fukudo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Restraint Stress ◽  
Dependent Manner ◽  
Corticotropin Releasing Hormone ◽  
Receptor Antagonists ◽  
Releasing Hormone ◽  
The Central Nervous System ◽  
Dose Dependent

We evaluated the possibility that serotonin (5-HT) mediates defecation induced by corticotropin-releasing hormone (CRH) exogenously administered or released from the central nervous system by stress via the 5-HT3 receptor in rats. Intracerebroventricular (ICV) injection of CRH (1, 3, and 10 μg/rat) dose dependently increased the number of stools excreted in rats, whereas intravenous (IV) injection of up to 100 μg/kg CRH did not affect defecation. α-Helical CRH-(9—41) and 5-HT3 receptor antagonists ramosetron and azasetron inhibited CRH (10 μg icv)-induced defecation in a dose-dependent manner with ED50 values of 4.3 μg/kg iv, 3.8 μg/kg po, and 70.4 μg/kg po, respectively. α-Helical CRH-(9—41) also inhibited CRH-induced defecation by ICV injection with an ED50 value of 0.078 μg/rat. In contrast, ramosetron and azasetron injectied ICV had no effect on CRH-induced defecation. α-Helical CRH-(9—41), ramosetron, and azasetron reduced defecation caused by restraint stress with ED50 values of 0.32, 3.6, and 19.7 μg/kg iv, respectively. These results indicate that CRH exogenously administered or released from the central nervous system by stress peripherally promotes the release of 5-HT, which in turn stimulates defecation through the 5-HT3 receptor.

Calcium receptor antagonists modify cocaine effects in the central nervous system differently

1990 ◽  
Vol 190 (1-2) ◽  
pp. 217-221 ◽  
Author(s):  
Luca Pani ◽  
Alexander Kuzmin ◽  
Marco Diana ◽  
Graziella De Montis ◽  
Gian Luigi Gessa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Calcium Receptor ◽  
Receptor Antagonists ◽  
The Central Nervous System
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