Cyproheptadine: a psychopharmacological treasure trove?

Cyproheptadine has a unique pharmacologic portfolio that speaks to the idea of a pluripotent molecule beyond an antiallergic agent which can expand its therapeutic potential to address a multitude of psychiatric indications. Here, authors touch on the topic with focused literature review of extant evidence.

Analiza olejku eterycznego z Liquiritiae radix

Introduction. Licorice root is used in folk medicine to treat cough, in addition to gastrointestinal inflammation and as a hepatoprotective and anti-cancer, antiallergic agent, locally for eczema, psoriasis, inflammation and skin pigmentation. The main active compounds are triterpene saponins and numerous flavonoids of various structures. Aim. The purpose of our research was to analyze the components of volatile oil obtained from commercial licorice root. Material and methods. The oil was obtained by hydrodistillation in a Clevenger apparatus and its composition was analyzed by GC-MS. Results. Among 47 compounds identified, mainly (47.42%), terpenes were present, in the dominant amount anethole (15.44%) and carvone (15.16%), in a smaller amount were present, among others: limonene, carvacrol, linalool, p-cymene, menthol, mentone, p-cymenol, palmitic acid, α-terpineol, geranyl tyglate. Conclusions. The identified compounds may be co-responsible for the biological activity of licorice root.