Upregulation of cytokeratins 8 and 18 in human breast cancer T47D cells is retinoid-specific and retinoic acid receptor-dependent

1996 ◽  
Vol 60 (2) ◽  
pp. 109-117 ◽  
Author(s):  
Yongkui Jing ◽  
Jie Zhang ◽  
Samuel Waxman ◽  
Rafael Mira-y-Lopez
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Human Breast Cancer ◽  
Retinoic Acid Receptor ◽  
Human Breast ◽  
T47d Cells ◽  
Acid Receptor

Retinoic acid receptor α1 isoform is induced by estradiol and confers retinoic acid sensitivity in human breast cancer cells

1995 ◽  
Vol 109 (1) ◽  
pp. 77-86 ◽  
Author(s):  
Bas-jan M. van der Leede ◽  
Gert E. Folkers ◽  
Christina E. van den Brink ◽  
Paul T. van der Saag ◽  
Bart van der Burg
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Retinoic Acid Receptor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Acid Sensitivity ◽  
Acid Receptor

scholarly journals Trastuzumab treatment in human breast cancer is associated with over-expression of the retinoic acid receptor alpha (RARA).

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Human Breast Cancer ◽  
Retinoic Acid Receptor ◽  
Human Breast ◽  
Retinoic Acid Receptor Alpha ◽  
Primary Tumors ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
Retinoid Acid

Treatment with trastuzumab has been associated with an increased risk of central nervous system metastasis in patients with human breast cancer (1-5). We performed unbiased transcriptome profiling of primary tumors of patients treated with trastuzumab using published microarray and multiplexed gene expression datasets (6, 7) to understand the transcriptional makeup of breast tumors in the trastuzumab-treated patients. We found that the retinoid acid receptor alpha was among the genes most differentially expressed in the primary tumors of patients treated with trastuzumab; retinoid acid receptor alpha was expressed at significantly higher levels in tumors from patients with trastuzumab as compared to those not treated with trastuzumab. Increased retinoic acid receptor alpha expression is known to confer tamoxifen resistance to human breast cancers (8), and RARA expression is higher in tumors with higher proliferative capacity (9), suggesting that trastuzumab could contribute to resistance to endocrine therapy.

scholarly journals Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta

2014 ◽  
Vol 18 (6) ◽  
pp. 1113-1123 ◽  
Author(s):  
Marina Inés Flamini ◽  
Gisel Valeria Gauna ◽  
Mayra Lis Sottile ◽  
Beatriz Silvina Nadin ◽  
Angel Matias Sanchez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Retinoic Acid Receptor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Retinoic Acid Receptor Beta ◽  
Receptor Beta
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