Apoptosis induction and cell cycle alterations by extract of Pistacia atlantica (Baneh) in comparison to tamoxifen in human breast cancer T47D cells

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
YY Kamrani ◽  
S Fouladdel ◽  
T Asgari ◽  
G Amin ◽  
B Esmaeelian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Human Breast Cancer ◽  
Apoptosis Induction ◽  
Human Breast ◽  
T47d Cells ◽  
Pistacia Atlantica ◽  
Cell Cycle Alterations

scholarly journals Comparative cellular and molecular analysis of cytotoxicity and apoptosis induction by doxorubicin and Baneh in human breast cancer T47D cells

2011 ◽  
Vol 63 (5) ◽  
pp. 503-512 ◽  
Author(s):  
P. Fathi Rezaei ◽  
Sh. Fouladdel ◽  
Silvia Cristofanon ◽  
S. M. Ghaffari ◽  
G. R. Amin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Analysis ◽  
Human Breast Cancer ◽  
Apoptosis Induction ◽  
Human Breast ◽  
T47d Cells

Molecular Mechanisms of Thymoquinone as Anticancer agent

2020 ◽  
Vol 23 ◽  
Author(s):  
Fatma Ismail Alhmied ◽  
Ali Hassan Alammar ◽  
Bayan Mohammed Alsultan ◽  
Marooj Alshehri ◽  
Faheem Hyder Pottoo
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Breast Cancer ◽  
Phase Cell ◽  
Cycle Phase ◽  
Human Breast ◽  
Cycle Arrest ◽  
Phase Arrest ◽  
Anti Cancer

Abstract:: Thymoquinone (TQ), the bioactive constituent of Nigella Sativa seeds is a well-known natural compound for the management of several types of cancers. The anti-cancer properties of thymoquinone are thought to be operated via intervening with various oncogenic pathways including cell cycle arrest, prevention of inflammation and oxidative stress, induction of invasion, metastasis, inhibition of angiogenesis, and apoptosis. As well as up-regulation and down-regulation of specific tumor suppressor genes and tumor promoting genes, respectively. Proliferation of various tumor cells is inhibited by TQ via induction of cell cycle arrest, disruption of the microtubule organization, and down regulating cell survival protein expression. TQ induces G1 phase cell cycle arrest in human breast cancer, colon cancer and osteosarcoma cells through inhibiting the activation of cyclin E or cyclin D and up-regulating p27and p21 a cyclin dependent kinase (Cdk) inhibitor. TQ concentration is a significant factor in targeting a particular cell cycle phase. While high concentration of TQ induced G2 phase arrest in human breast cancer (MCF-7) cells, low concentration causes S phase arrest. This review article provides mechanistic insights into the anti-cancer properties of thymoquinone.

Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase

2017 ◽  
Vol 69 (5) ◽  
pp. 924-928 ◽  
Author(s):  
Maliheh Moradzadeh ◽  
Azar Hosseini ◽  
Saiedeh Erfanian ◽  
Hadi Rezaei
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Down Regulation ◽  
T47d Cells
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