Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with Type 1 diabetes mellitus: relation to glycaemic control and microvascular complications

2000 ◽  
Vol 17 (9) ◽  
pp. 650-656 ◽  
Author(s):  
F. Chiarelli ◽  
A. Spagnoli ◽  
F. Basciani ◽  
S. Tumini ◽  
A. Mezzetti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Endothelial Growth Factor ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Growth Factor ◽  
Glycaemic Control ◽  
Microvascular Complications ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Kailash Singh ◽  
Stellan Sandler ◽  
Daniel Espes
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Metabolic Control ◽  
Plasma Levels ◽  
Microvascular Complications ◽  
University Hospital ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Aim.To characterize the plasma levels of vascular endothelial growth factor (VEGF) in type 1 diabetes mellitus (T1D) and its relation to both present and historical metabolic control and microvascular complications.Methods.Plasma levels of VEGF and routine clinical parameters were analyzed in 115 patients with long-standing T1D and 45 healthy controls (HC). All patients were under clinical routine diabetes treatment at Uppsala University Hospital.Results.The plasma levels of VEGF were increased by 37% in patients with T1D when compared to HC (18.2±0.8versus13.2±1.0 pg/ml,p<0.001). The levels of VEGF correlated to insulin needs and BMI but not to present or historical metabolic control. The levels of VEGF were similar in patients with T1D and microvascular complications (microalbuminuria and retinopathy) when compared with patients without microvascular complications. Historical HbA1c levels were found to be the best predictor for present metabolic control.Conclusion.Circulating plasma levels of VEGF do not correlate to present or historical metabolic control in long-standing T1D and the levels are not affected by the presence of microvascular complications.

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