scholarly journals The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Kailash Singh ◽  
Stellan Sandler ◽  
Daniel Espes
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Metabolic Control ◽  
Plasma Levels ◽  
Microvascular Complications ◽  
University Hospital ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Aim.To characterize the plasma levels of vascular endothelial growth factor (VEGF) in type 1 diabetes mellitus (T1D) and its relation to both present and historical metabolic control and microvascular complications.Methods.Plasma levels of VEGF and routine clinical parameters were analyzed in 115 patients with long-standing T1D and 45 healthy controls (HC). All patients were under clinical routine diabetes treatment at Uppsala University Hospital.Results.The plasma levels of VEGF were increased by 37% in patients with T1D when compared to HC (18.2±0.8versus13.2±1.0 pg/ml,p<0.001). The levels of VEGF correlated to insulin needs and BMI but not to present or historical metabolic control. The levels of VEGF were similar in patients with T1D and microvascular complications (microalbuminuria and retinopathy) when compared with patients without microvascular complications. Historical HbA1c levels were found to be the best predictor for present metabolic control.Conclusion.Circulating plasma levels of VEGF do not correlate to present or historical metabolic control in long-standing T1D and the levels are not affected by the presence of microvascular complications.

Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic cardiomyopathy

2009 ◽  
Vol 297 (2) ◽  
pp. H829-H835 ◽  
Author(s):  
Bing Han ◽  
Reshma Baliga ◽  
Hong Huang ◽  
Peter J. Giannone ◽  
John Anthony Bauer
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Redox Imbalance ◽  
Endothelial Growth Factor ◽  
Vegf Isoforms ◽  
Fractional Shortening ◽  
Microvascular Rarefaction

Type 1 diabetes is associated with a unique form of cardiomyopathy that is present without atherosclerosis. Redox imbalance and/or changes in vascular endothelial growth factor (VEGF) expression have been associated with diabetes-related cardiomyopathy. However, the mechanisms of these changes and their interrelationships remain unclear. Using a murine type 1 diabetes model, we tested the hypothesis that alterations in cardiac performance are associated with decreased cardiac microvascular prevalence, as well as downregulation of VEGF isoforms. We also investigated oxidative stress as a contributor to regulate individual VEGF isoforms and microvascular rarefaction. Significant and rapid hyperglycemia was observed at 1 wk post-streptozotocin (STZ) and persisted throughout the 5-wk study. Left ventricular (LV) fractional shortening was reduced at week 1 and 5 post-STZ insult relative to age-matched controls. We also observed the early reduction in E/A ratio at 1 wk. Immunostaining for CD31 and digital image analysis demonstrated a 35% reduction in microvessels/myocardial area, indicative of rarefaction, which was highly correlated with fractional shortening. Furthermore, a significant increase in the prevalence of protein 3-nitrotyrosine was observed in the diabetic cardiac tissue, which was inversely associated with microvascular rarefaction. The expressions of three VEGF isoforms were significantly reduced to different extents. The reduction of VEGF164 was associated with GSSG accumulation. These data demonstrate that the mouse model of STZ-induced diabetes has hallmark features observed in humans with respect to nonischemic systolic and diastolic performance and microvascular rarefaction, which are associated with changes in VEGF isoform expression and redox imbalance in the myocardium.

scholarly journals Multiple Variants in Vascular Endothelial Growth Factor (VEGFA) Are Risk Factors for Time to Severe Retinopathy in Type 1 Diabetes

Diabetes ◽  
2007 ◽  
Vol 56 (8) ◽  
pp. 2161-2168 ◽  
Author(s):  
Hussam Al-Kateb ◽  
Lucia Mirea ◽  
Xinlei Xie ◽  
Lei Sun ◽  
Michelle Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vascular Endothelial Growth Factor ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Multiple Variants
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