Tumour necrosis factor-alpha plasma levels in elderly patients with Type 2 diabetes mellitus-observations over 2 years

2002 ◽  
Vol 19 (11) ◽  
pp. 949-953 ◽  
Author(s):  
M. Lechleitner ◽  
M. Herold ◽  
C. Dzien-Bischinger ◽  
F. Hoppichler ◽  
A. Dzien
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Elderly Patients ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

2011 ◽  
Vol 30 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Juan Manuel Guzmán-Flores ◽  
José Francisco Muñoz-Valle ◽  
José Sánchez-Corona ◽  
José G. Cobián ◽  
Leopoldo Medina-Carrillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

The association between some Tumor necrosis factor-alpha (TNF-α) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. The aim of this study was to investigate the association between −308G/A and −238G/A polymorphisms located in the promoter region of the TNF-αgene and T2DM in Mexican mestizo patients. Nine hundred four individuals (259 patients with T2DM and 645 controls) were genotyped for the −308G/A and −238G/A polymorphisms by PCR—RFLP. We found that the −238A allele increased the risk of developing T2DM in Mexican patients (OR = 1.57, 95% CI: 1.07–2.29;p= 0.018). Moreover, we found that the frequency of the GA haplotype (created by the −308G and −238A alleles) was significantly increased in patients with T2DM when compared with controls (OR = 1.56, 95% CI: 1.05–2.31;p= 0.026). Our results suggest that the −238G/A polymorphism and a specific haplotype (GA) are genetic risk factors for the development of T2DM in Mexican population.

scholarly journals Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis

2018 ◽  
Vol 7 (1) ◽  
pp. 25-31
Author(s):  
Ali Hasanpour Dehkordi ◽  
Majid Dousti ◽  
Faezeh Kiani ◽  
Mona Zamanian Azodi ◽  
Mostafa RezaeiTavirani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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