Brain pH in Migraine: An In Vivo Phosphorus-31 Magnetic Resonance Spectroscopy Study

Cephalalgia ◽  
1988 ◽  
Vol 8 (4) ◽  
pp. 273-277 ◽  
Author(s):  
K M A Welch ◽  
Steven R Levine ◽  
Giovanni D'Andrea ◽  
J A Helpern
Keyword(s):  
Cerebral Cortex ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Migraine Attack ◽  
Resonance Spectroscopy ◽  
Spectroscopy Study ◽  
Magnetic Resonance Spectroscopy Study ◽  
Brain Ph

The intracellular pH (pHi) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vaso-dilatation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.

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