Auditory Evoked Potentials in the Assessment of Central Nervous                     System Effects of Antimigraine Drugs

Because the “intensity dependence” of cortical auditory evoked potentials (IDAP) is under serotonergic control, it can be used to assess central antimigraine effects of 5HT1B/1D agonists. We measured IDAP before and 2 h after naratriptan (5 mg, n = 19) and zolmitriptan (5 mg, n = 19) in healthy volunteers. IDAP was expressed as the amplitude-stimulus intensity function (“ASF slope”). Naratriptan tended to increase ASF slope (mean difference 0.23 ± 0.62 μV/10 dB, p = 0.06) while zolmitriptan (0.08 ± 0.95 μV/10 dB, p = 0.35) did not. We assessed the suitability of IDAP for measuring central antimigraine drug effects using repeatability data (see companion paper). We calculated the trade-off between the size of the expected drug effects (ASF slope difference) and the necessary sample size. Because of poor repeatability 36 to 80 subjects are required to detect ASF slope changes in the 0.25–0.5 μV/10 dB range. These data can be used to design trials using IDAP.

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Intensity Dependence of the Cortical Auditory Evoked Potentials as A Surrogate Marker of Central Nervous System Serotonin Transmission in Man: Demonstration of A Central Effect for the 5Ht1B/1D Agonist Zolmitriptan (311C90, Zomig®).

Cephalalgia ◽

10.1046/j.1468-2982.1997.1708849.x ◽

1997 ◽

Vol 17 (8) ◽

pp. 849-854 ◽

Cited By ~ 66

Author(s):

A Proietti-Cecchini ◽

J Áfra ◽

J Schoenen

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Evoked Potentials ◽

Animal Studies ◽

Auditory Evoked Potentials ◽

Surrogate Marker ◽

Serotonin Release ◽

Intensity Dependence ◽

Sensory Cortices ◽

Cortical Auditory Evoked Potentials

As shown in animal studies, 5HT1B/1D agonists can inhibit activity in the trigeminal nucleus caudalis, which may be advantageous for their antimigraine effect. To demonstrate a possible central nervous system (CNS) action of these compounds in man we studied their effect on the intensity dependence of the cortical auditory evoked potentials (IDAPs), thought to be inversely related to central serotonergic transmission. An amplitude/stimulus intensity function (ASF) slope was computed in healthy volunteers and migraine patients between attacks before and 2 h after oral 311C90 (zolmitriptan “Zomig”) 10 mg ( n=14), 311C90 5 mg ( n=7), sumatriptan 100 mg ( n=14), dexfenfluramine 15 mg ( n=4), lorazepam 1.25 mg ( n=4) and placebo ( n=14). 311C90 10 mg and, to a lesser degree, 5 mg significantly increased the mean ASF slope ( p=0.007 and 0.05 vs placebo). There was a significant positive correlation between plasma levels of 311C90 and ASF slope changes. Sumatriptan and lorazepam had little effect, but dexfenfluramine produced a significant ASF slope decrease. 311C90 is able to modify a CNS activity that is modulated by serotonin, i.e. the IDAP. This effect is probably the consequence of its super or lipophilicity compared to sumatriptan and of activation of prejunctional 5HT1B/1D autoreceptors, which lowers central serotonin release and thus the preactivation level of sensory cortices.

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Cluster Headache Patients Show Marked Intensity Dependence of Cortical Auditory Evoked Potentials during and outside the Bout

Cephalalgia ◽

10.1111/j.1468-2982.2004.00801.x ◽

2005 ◽

Vol 25 (1) ◽

pp. 36-40 ◽

Cited By ~ 11

Author(s):

J Áfra ◽

C Ertsey ◽

G Bozsik ◽

I Jelencsik

Keyword(s):

Cluster Headache ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Intensity Function ◽

Control Group ◽

Intensity Dependence ◽

Cluster Group ◽

Serotonergic Activity ◽

Serotonergic Neurotransmission ◽

Cortical Auditory Evoked Potentials

Central serotonergic neurotransmission was assessed using intensity dependence of cortical auditory evoked potentials (IDAP) in cluster headache (CH) patients during both the active and interictal period. In 15 episodic CH patients and 13 controls previously described methods were used and amplitude-stimulus intensity function (ASF) slopes were computed. In the cluster group mean ASF slope was significantly steeper than in the control group both during the active period (1.53 + 0.90 vs. 0.77 + 0.85, P = 0031) and interictally (1.85 + 1.20 vs. 0.77 + 0.85, P = 0012). In the cluster group IDAPs of active and interictal period did not differ significantly ( P = 0378). Duration of the disease or the present bout, distance from the last attack did not correlate with ASF slopes. In conclusion, our results are compatible with decreased level of serotonergic neurotransmission in raphe-cortical pathways. Diminished serotonergic activity in raphe-hypothalamic serotonergic pathways might be hypothesized influencing the activity of hypothalamic neurons and thus play a role in the genesis of cluster headache.

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Late Auditory Evoked Potentials: A Method for Monitoring Drug Effects on the Central Nervous System

Neuropsychobiology ◽

10.1159/000118715 ◽

1990 ◽

Vol 23 (1) ◽

pp. 48-52 ◽

Cited By ~ 11

Author(s):

N.E. Noldy ◽

J. Neiman ◽

B. El-Nesr ◽

P.L. Carlen

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Drug Effects ◽

Monitoring Drug ◽

The Central Nervous System ◽

Late Auditory Evoked Potentials

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Comparison of Silent Gap in Noise Cortical Auditory Evoked Potentials in Matched Tinnitus and No-Tinnitus Control Subjects

American Journal of Audiology ◽

10.1044/2018_aja-18-0074 ◽

2019 ◽

Vol 28 (2) ◽

pp. 260-273 ◽

Cited By ~ 2

Author(s):

Kenneth Morse ◽

Kathy R. Vander Werff

Keyword(s):

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Control Subjects ◽

Cortical Auditory Evoked Potentials

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New possibility for measuring the cortical auditory evoked potentials: the HEARLab

Orvosi Hetilap ◽

10.1556/oh.2014.29992 ◽

2014 ◽

Vol 155 (38) ◽

pp. 1524-1529

Author(s):

Ádám Bach ◽

Ferenc Tóth ◽

Vera Matievics ◽

József Géza Kiss ◽

József Jóri ◽

...

Keyword(s):

Clinical Practice ◽

Evoked Potentials ◽

Auditory System ◽

Hearing Aids ◽

Pure Tone ◽

Auditory Evoked Potentials ◽

Normal Hearing ◽

Speech Stimuli ◽

Novel Method ◽

Cortical Auditory Evoked Potentials

Introduction: Cortical auditory evoked potentials can provide objective information about the highest level of the auditory system. Aim: The purpose of the authors was to introduce a new tool, the “HEARLab” which can be routinely used in clinical practice for the measurement of the cortical auditory evoked potentials. In addition, they wanted to establish standards of the analyzed parameters in subjects with normal hearing. Method: 25 adults with normal hearing were tested with speech stimuli, and frequency specific examinations were performed utilizing pure tone stimuli. Results: The findings regarding the latency and amplitude analyses of the evoked potentials confirm previously published results of this novel method. Conclusions: The HEARLAb can be a great help when performance of the conventional audiological examinations is complicated. The examination can be performed in uncooperative subjects even in the presence of hearing aids. The test is frequency specific and does not require anesthesia. Orv. Hetil., 2014, 155(38), 1524–1529.

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