scholarly journals An EM algorithm for obtaining maximum likelihood estimates in the multi-phenotype variance components linkage model

2000 ◽  
Vol 64 (4) ◽  
pp. 349-362 ◽  
Author(s):  
S. J. ITURRIA ◽  
J. BLANGERO
2018 ◽  
Vol 41 (1) ◽  
pp. 75-86
Author(s):  
Taciana Shimizu ◽  
Francisco Louzada ◽  
Adriano Suzuki

In this paper, we consider to evaluate the efficiency of volleyball players according to the performance of attack, block and serve, but considering the compositional structure of the data related to the fundaments. The finite mixture of regression models better fitted the data in comparison with the usual regression model. The maximum likelihood estimates are obtained via an EM algorithm. A simulation study revels that the estimates are closer to the real values, the estimators are asymptotically unbiased for the parameters. A real Brazilian volleyball dataset related to the efficiency of the players is considered for the analysis.


2022 ◽  
Author(s):  
Lenore Pipes ◽  
Zihao Chen ◽  
Svetlana Afanaseva ◽  
Rasmus Nielsen

Wastewater surveillance has become essential for monitoring the spread of SARS-CoV-2. The quantification of SARS-CoV-2 RNA in wastewater correlates with the Covid-19 caseload in a community. However, estimating the proportions of different SARS-CoV-2 strains has remained technically difficult. We present a method for estimating the relative proportions of SARS-CoV-2 strains from wastewater samples. The method uses an initial step to remove unlikely strains, imputation of missing nucleotides using the global SARS-CoV-2 phylogeny, and an Expectation-Maximization (EM) algorithm for obtaining maximum likelihood estimates of the proportions of different strains in a sample. Using simulations with a reference database of >3 million SARS-CoV-2 genomes, we show that the estimated proportions accurately reflect the true proportions given sufficiently high sequencing depth and that the phylogenetic imputation is highly accurate and substantially improves the reference database.


2021 ◽  
Author(s):  
Masahiro Kuroda

Mixture models become increasingly popular due to their modeling flexibility and are applied to the clustering and classification of heterogeneous data. The EM algorithm is largely used for the maximum likelihood estimation of mixture models because the algorithm is stable in convergence and simple in implementation. Despite such advantages, it is pointed out that the EM algorithm is local and has slow convergence as the main drawback. To avoid the local convergence of the EM algorithm, multiple runs from several different initial values are usually used. Then the algorithm may take a large number of iterations and long computation time to find the maximum likelihood estimates. The speedup of computation of the EM algorithm is available for these problems. We give the algorithms to accelerate the convergence of the EM algorithm and apply them to mixture model estimation. Numerical experiments examine the performance of the acceleration algorithms in terms of the number of iterations and computation time.


2014 ◽  
Vol 1049-1050 ◽  
pp. 1343-1346
Author(s):  
Yong Li

EM algorithm is a very popular algorithm in missing data analysis. However,The variance of the estimator from EM is intractable. In this paper, we propose the supplemented EM algorithm for computing the variance that do not require computation and inversion of the information matrix.


1979 ◽  
Vol 28 (1-4) ◽  
pp. 125-142 ◽  
Author(s):  
Kalyan Das

In this paper we study the asymptotic optimality of the restricted maximum likelihood estimates of variance components in the mixed model of analysis of variance. Using conceptual design sequences of Miller (1977), under slightly stronger conditions, we show that the restricted maximum likelihood estimates are not only asymptotically normal, but also asymptotically equivalent to the maximum likelihood estimates in a reasonable sense.


2016 ◽  
Vol 16 (2) ◽  
pp. 16-34 ◽  
Author(s):  
D. Raja Kishor ◽  
N. B. Venkateswarlu

Abstract The present work proposes hybridization of Expectation-Maximization (EM) and K-means techniques as an attempt to speed-up the clustering process. Even though both the K-means and EM techniques look into different areas, K-means can be viewed as an approximate way to obtain maximum likelihood estimates for the means. Along with the proposed algorithm for hybridization, the present work also experiments with the Standard EM algorithm. Six different datasets, three of which synthetic datasets, are used for the experiments. Clustering fitness and Sum of Squared Errors (SSE) are computed for measuring the clustering performance. In all the experiments it is observed that the proposed algorithm for hybridization of EM and K-means techniques is consistently taking less execution time with acceptable Clustering Fitness value and less SSE than the standard EM algorithm. It is also observed that the proposed algorithm is producing better clustering results than the Cluster package of Purdue University.


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