scholarly journals TP53 Polymorphism of Exon 4 at Codon 72 in Cutaneous Squamous Cell Carcinoma and Benign Epithelial Lesions of Renal Transplant Recipients and Immunocompetent Individuals: Lack of Correlation with Human Papillomavirus Status11This work was presented in part at the 19th International Papillomavirus Conference in Florianopolis, Brazil, September 1–7, 2001.

2002 ◽  
Vol 118 (6) ◽  
pp. 1026-1031 ◽  
Author(s):  
Sandrine Cairey-Remonnay ◽  
Olivier Humbey ◽  
Christiane Mougin ◽  
Marie P. Algros ◽  
Frédéric Mauny ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Renal Transplant ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Codon 72 ◽  
Exon 4 ◽  
Epithelial Lesions ◽  
Tp53 Polymorphism

scholarly journals Susceptibility to Cutaneous Squamous Cell Carcinoma in Renal Transplant Recipients Associates with Genes Regulating Melanogenesis Independent of their Role in Pigmentation

2013 ◽  
Vol 5 ◽  
pp. BIC.S12754 ◽  
Author(s):  
Per A. Andresen ◽  
Dag A. Nymoen ◽  
Kristina Kjærheim ◽  
Torbjørn Leivestad ◽  
Per Helsing
Keyword(s):  
Squamous Cell Carcinoma ◽  
Renal Transplant ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Hair Color ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Melanocortin 1 Receptor ◽  
Red Hair

The highly polymorphic melanocortin 1 receptor ( MC1R) gene plays a crucial role in pigmentation. Variants of the gene have been implicated in risk of cutaneous squamous cell carcinoma (SCC) in the general population. In renal transplant (RT) recipients these cancers are more aggressive and very common. To evaluate the risk of SCC relative to MC1R and the pigmentation-associated genes ASIP, TYR, and TYRP1, a group of 217 RT recipients with and without SCC was genotyped. Associations with SCC risk were indicated in carriers of the red hair color associated MC1R variant p.Arg151Cys (OR= 1.99; 1.05–-3.75), and in carriers of two of any of the MC1R variants disclosed (OR = 2.36; 1.08–5.15). These associations appeared independent of traditionally protective phenotypes, also supported by the stratifications from skin phototype and hair color. A tendency towards an increased SCC risk was observed for a specific ASIP haplotype (OR = 1.87; 0.91–3.83), while no such associations were observed for the TYR and TYRP1 variants. Thus, the risk of developing SCC in RT patients is modulated by MC1R variation irrespective of phenotypes considered to be protective. Heterozygous combinations of MC1R variants appear to be more relevant in assessing SCC risk than the effects of variants individually.

scholarly journals Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of TMC/EVER Alterations

Dermatology ◽  
2015 ◽  
Vol 231 (3) ◽  
pp. 245-252
Author(s):  
Bettina Burger ◽  
Iris Sp�rri ◽  
Danielle A. Stegmann ◽  
Julie De Mesmaker ◽  
Stefan Schaub ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Renal Transplant ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Renal Transplant Recipients ◽  
Transplant Recipients
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