Proliferating cell nuclear antigen (PCNA) immunoreactivity in ovarian serous and mucinous neoplasms: diagnostic and prognostic value

1993 ◽  
Vol 3 (6) ◽  
pp. 391-394 ◽  
Author(s):  
N. Wilkinson ◽  
C. H. Buckley ◽  
H. Fox ◽  
R. J. Hale ◽  
L. Chawner ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Malignant Tumors ◽  
Nuclear Antigen ◽  
Malignant Neoplasms ◽  
Positive Staining ◽  
Patient Death ◽  
Mucinous Neoplasms ◽  
Positive Immunoreactivity ◽  
Proliferating Cell

Sixty-two serous and mucinous ovarian tumors, an admixture of benign, borderline and malignant neoplasms, were immunostained for proliferating cell nuclear antigen (PCNA), with the monoclonal antibody PC10. The PC10 index, the proportion of cells showing nuclear positive staining, was calculated in each case. All the tumors showed positive immunoreactivity for PCNA. There was no overlap of PC10 counts between benign, borderline and malignant serous tumors but within the mucinous group of neoplasms there was considerable overlap between the counts for borderline and malignant tumors. There was no relationship between the PC10 index and the surgical stage of the malignant neoplasms and the index could not be correlated with patient death. Staining for PCNA does not, therefore, appear to be of any prognostic value in ovarian adenocarcinomas.

scholarly journals Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Taewoo Yang ◽  
Yegyun Choi ◽  
Jae Won Joh ◽  
Steve K. Cho ◽  
Dae-Shick Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Nuclear Antigen ◽  
Survival Outcomes ◽  
P53 Expression ◽  
Immunohistochemical Markers ◽  
Prognostic Utility ◽  
Poor Outcomes ◽  
Proliferating Cell

Background. Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. Several commonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility of p53 expression in HCC has remained elusive. Aim. To evaluate the prognostic value of p53 and p53 phosphorylation at serine 15 (p53 Ser15-P) in patients with HCC. Methods. Surgically resected tumors from 199 HCC patients were analyzed for p21, p53, p53 Ser15-P, and proliferating cell nuclear antigen (PCNA) expression using immunohistochemistry. Results. Stratifying by the expression of p53 Ser15-P (P = 0.016), but not by p53 (P = 0.301), revealed significantly different survival outcomes in patients with HCC. Moreover, our analysis demonstrated that patients who were PCNA-positive and p53 Ser15-P–negative had significantly worse survival outcomes (P = 0.001) than patients who were PCNA-positive and p53 Ser15-P–positive. Conclusions. P53 Ser15-P is associated with poor outcomes in patients with HCC, and this prognostic marker is useful for predicting the survival of patients with PCNA-positive HCC.

Prognostic value of proliferating cell nuclear antigen in parotid gland cancer

2011 ◽  
Vol 269 (4) ◽  
pp. 1225-1232 ◽  
Author(s):  
Markus Stenner ◽  
Ariane Demgensky ◽  
Christoph Molls ◽  
Aline Hardt ◽  
Jan C. Luers ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Nuclear Antigen ◽  
Parotid Gland Cancer ◽  
Proliferating Cell

Cell Proliferation as Assessed by Expression of Proliferating Cell Nuclear Antigen or the Uptake of Bromodeoxyuridine in a Rabbit Model of Leg-lengthening

1996 ◽  
Vol 09 (03) ◽  
pp. 95-100 ◽  
Author(s):  
G. Li ◽  
A. H. R. W. Simpson ◽  
J. Kenwright ◽  
J. T. Triffitt
Keyword(s):  
Cell Proliferation ◽  
Proliferating Cell Nuclear Antigen ◽  
Rabbit Model ◽  
Experimental System ◽  
Nuclear Antigen ◽  
Positive Staining ◽  
Leg Lengthening ◽  
Staining Index ◽  
Proliferating Cell ◽  
Distraction Rate

SummaryAn experimental model of leg lengthening has been used to study the cellular responses of the regenerating bone to different rates of distraction. Cell proliferation were assessed by detection of proliferating cell nuclear antigen using a monoclonal antibody, PC10. The technique was verified by comparison with bromodeoxyuridine uptake and subsequent detection with specific antibody (Bu20A). The positive staining index (PSI) was calculated for a variety of tissues and the PC10 PSI was greater than that of Bu20A, as described by the expression: PC10 PSI = 1.6 Bu20A PSI + 12.9, with a correlation coefficient 0.79. The results suggest that PC10 may be used as an alternative marker to assess cell proliferation in rabbit regenerating bone tissue. In addition, the rate of cell proliferation during leg-lengthening was found to reach a maximum at a distraction rate of 0.7 mm/day without further change at higher rates.Cell proliferation was assessed in an experimental system of leg-lengthening by two separate methods. The presence of proliferating cell nuclear antigen or the uptake of bromodeoxyuridine were determined immuno-histochemically. Both methods indicated cell proliferation during leg-lengthening reaches a maximum at a distraction rate of 0.7 mm/day.

Prognostic value of proliferating cell nuclear antigen immunostaining in pediatric rhabdomyosarcomas

1998 ◽  
Vol 40 (6) ◽  
pp. 573-579 ◽  
Author(s):  
GÜLnur TokuÇ ◽  
ÖNer DoǧAn ◽  
İNcİ Ayan ◽  
RejİN Kebudİ ◽  
Sema DoǧAn ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Nuclear Antigen ◽  
Proliferating Cell
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