The Prognostic Value of Cell Proliferation in Colorectal Adenomas Assessed with Tritiated Thymidine and Anti-Proliferating Cell Nuclear Antigen

1999 ◽  
Vol 23 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Giulia Ottaviani ◽  
Anna Maria Lavezzi ◽  
Fausto De Ruberto ◽  
Giuseppe Fichera ◽  
Luigi Matturri
Keyword(s):  
Cell Proliferation ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Tritiated Thymidine ◽  
Colorectal Adenomas ◽  
Nuclear Antigen ◽  
Proliferating Cell

scholarly journals Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation.

Gut ◽  
1994 ◽  
Vol 35 (4) ◽  
pp. 530-535 ◽  
Author(s):  
F J Kubben ◽  
A Peeters-Haesevoets ◽  
L G Engels ◽  
C G Baeten ◽  
B Schutte ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Proliferating Cell

scholarly journals Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Taewoo Yang ◽  
Yegyun Choi ◽  
Jae Won Joh ◽  
Steve K. Cho ◽  
Dae-Shick Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Nuclear Antigen ◽  
Survival Outcomes ◽  
P53 Expression ◽  
Immunohistochemical Markers ◽  
Prognostic Utility ◽  
Poor Outcomes ◽  
Proliferating Cell

Background. Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. Several commonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility of p53 expression in HCC has remained elusive. Aim. To evaluate the prognostic value of p53 and p53 phosphorylation at serine 15 (p53 Ser15-P) in patients with HCC. Methods. Surgically resected tumors from 199 HCC patients were analyzed for p21, p53, p53 Ser15-P, and proliferating cell nuclear antigen (PCNA) expression using immunohistochemistry. Results. Stratifying by the expression of p53 Ser15-P (P = 0.016), but not by p53 (P = 0.301), revealed significantly different survival outcomes in patients with HCC. Moreover, our analysis demonstrated that patients who were PCNA-positive and p53 Ser15-P–negative had significantly worse survival outcomes (P = 0.001) than patients who were PCNA-positive and p53 Ser15-P–positive. Conclusions. P53 Ser15-P is associated with poor outcomes in patients with HCC, and this prognostic marker is useful for predicting the survival of patients with PCNA-positive HCC.

scholarly journals Proliferating Cell Nuclear Antigen as the Cell Cycle Sensor for an HLA-Derived Peptide Blocking T Cell Proliferation

2000 ◽  
Vol 164 (12) ◽  
pp. 6188-6192 ◽  
Author(s):  
Xuefeng Ling ◽  
Salar Kamangar ◽  
Michelle L. Boytim ◽  
Zvi Kelman ◽  
Philip Huie ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
T Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
T Cell Proliferation ◽  
Proliferating Cell

Prognostic value of proliferating cell nuclear antigen in parotid gland cancer

2011 ◽  
Vol 269 (4) ◽  
pp. 1225-1232 ◽  
Author(s):  
Markus Stenner ◽  
Ariane Demgensky ◽  
Christoph Molls ◽  
Aline Hardt ◽  
Jan C. Luers ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Nuclear Antigen ◽  
Parotid Gland Cancer ◽  
Proliferating Cell
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