Absence of hepatitis B virus DNA detected by polymerase chain reaction in blood donors who are hepatitis B surface antigen negative and antibody to hepatitis B core antigen positive from a United States population with a low prevalence of hepatitis B serologic markers

Transfusion ◽  
1993 ◽  
Vol 33 (3) ◽  
pp. 212-216 ◽  
Author(s):  
DD Douglas ◽  
HF Taswell ◽  
J Rakela ◽  
D Rabe
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Core Antigen ◽  
Chain Reaction ◽  
United States Population ◽  
B Virus ◽  
Polymerase Chain ◽  
Hepatitis B Core Antigen ◽  
Low Prevalence

scholarly journals Hepatitis B Virus DNA in Blood Samples Positive for Antibodies to Core Antigen and Negative for Surface Antigen

1999 ◽  
Vol 6 (5) ◽  
pp. 768-770 ◽  
Author(s):  
C. Gutiérrez ◽  
G. León ◽  
C. L. Loureiro ◽  
N. Uzcátegui ◽  
F. Liprandi ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Core Antigen ◽  
Blood Samples ◽  
Positive Hbsag ◽  
B Virus ◽  
Low Levels ◽  
Hepatitis B Core Antigen

ABSTRACT Anti-hepatitis B core antigen (HBcAg)-positive hepatitis B surface antigen (HBsAg)-negative plasma samples from blood donors were tested by nested PCR. DNA positivity was more significantly associated with high levels of anti-HBcAg than with low levels of anti-HBsAg antibodies. Analysis of a dilution of anti-HBcAg antibodies might result in a more rational exclusion of anti-HBcAg-positive HBsAg-negative samples, reducing the number of donations discarded and enabling more countries to incorporate anti-HBcAg testing.

Serologic Evidence for Hepatitis B Virus Infection in Patients with Hemophilia B

1975 ◽  
Vol 33 (03) ◽  
pp. 606-609 ◽  
Author(s):  
Jay H Hoofnagle ◽  
David Aronson ◽  
Harold Roberts
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Factor Ix ◽  
Hemophilia B ◽  
Core Antigen ◽  
B Virus ◽  
Serologic Evidence ◽  
Hepatitis B Core Antigen ◽  
North And South America

SummaryAmong sera from 160 patients with hemophilia B from 9 centers in Europe and North and South America, 2.5% were positive for hepatitis B surface antigen (HBsAg), 60% for antibody to HBsAg, and 31% for antibody to the hepatitis B core antigen. Evidence of exposure to the hepatitis B virus appeared to be related to severity of disease and age rather than the source and method of manufacturer of factor IX concentrate.

Persistence of serum antibody to hepatitis B core antigen

1977 ◽  
Vol 6 (3) ◽  
pp. 209-211
Author(s):  
B G Hansson
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Normal Population ◽  
Hepatitis B Surface Antigen ◽  
Serum Antibody ◽  
Observation Time ◽  
Acute Stage ◽  
Core Antigen ◽  
B Virus ◽  
Hepatitis B Core Antigen

The purpose of the present study was to measure the amount of antibody to hepatitis B core antigen (anti-HBc) in different populations by the immunoelectroosmophoresis method. High titers of anti-HBc, up to 1/4,096, were found in the acute stage of hepatitis B virus infections and in the chronic carrier state of hepatitis B surface antigen. In cases of acute hepatitis the anti-HBc titers gradually declined to low levels but persisted for the observation time of 5 to 6 years. Individuals positive for antibodies to hepatitis B surface and core antigens selected from a Swedish "normal" population showed still lower anti-HBc titers, indicating that the hepatitis B infection had occurred earlier. The anti-HBc titers in sera drawn at intervals of 4 years from a group of hemophilia patients may indicate previous infection with replicating hepatitis B virus rather than immunization with noninfectious hepatitis B core antigen material.

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