scholarly journals Analysis on Stem cell Treatment of Alzheimer's Disease

2021 ◽  
Vol 271 ◽  
pp. 03072
Author(s):  
Weixun Zhu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Neurodegenerative Diseases ◽  
Cell Transplantation ◽  
Memory Loss ◽  
Cell Therapies ◽  
Stem Cell Treatment

Alzheimer's disease is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment. At present, conventional drugs have little effect on the prevention and treatment of AD, and the rapidly developing stem cell transplantation therapy provides a new direction for the treatment of neurodegenerative diseases. In this paper, we can conclude that stem cell therapies such as neural stem cells and mesenchymal stem cells have shown curative effects in the treatment of neurodegenerative diseases such as Alzheimer’s disease by analyzing existing stem cell research and analysis at this stage, and there will be huge applications in the future. prospect. Stem cells can secrete immunoregulatory factors through paracrine pathways to inhibit inflammation and reduce the accumulation of amyloid. Secrete neurotrophic factors to protect and promote nerve growth. In addition, stem cells can differentiate into neurons after transplantation, replacing damaged and dead nerve cells, and play an important role in rebuilding brain neural circuits and networks. This article analyzes and summarizes the possible ways of stem cell transplantation to treat Alzheimer's disease, which can provide new ideas and methods for future stem cell transplantation therapies.

Stem Cell-based Therapeutic and Diagnostic Approaches in Alzheimer's Disease

2021 ◽  
Vol 20 ◽  
Author(s):  
Sadaf Abdi ◽  
Nima Javanmehr ◽  
Maryam Ghasemi-Kasman ◽  
Hanie Yavarpour Bali ◽  
Marzieh Pirzadeh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Clinical Trials ◽  
Stem Cell ◽  
Memory Loss ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Advantages And Disadvantages ◽  
Diagnostic Approaches

Background: Alzheimer’s disease (AD) is a neurodegenerative impairment mainly recognized by memory loss and cognitive deficits. However, the current therapies against AD are mostly limited to palliative medications, prompting researchers to investigate more efficient therapeutic approaches for AD, such as stem cell therapy. Recent evidence has proposed that extensive neuronal and synaptic loss and altered adult neurogenesis, which is perceived pivotal in terms of plasticity and network maintenance, occurs early in the course of AD, which exacerbates neuronal vulnerability to AD. Thus, regeneration and replenishing the depleted neuronal networks by strengthening the endogenous repair mechanisms or exogenous stem cells and their cargoes is a rational therapeutic approach. Currently, several stem cell-based therapies as well as stem cell products like exosomes, have shown promising results in the early diagnosis of AD. Objective: This review begins with a comparison between AD and normal aging pathophysiology and a discussion on open questions in the field. Next, summarizing the current stem cell-based therapeutic and diagnostic approaches, we declare the advantages and disadvantages of each method. Also, we comprehensively evaluate the human clinical trials of stem cell therapies for AD. Methodology: Peer-reviewed reports were extracted through Embase, PubMed, and Google Scholar until 2021. Results: With several ongoing clinical trials, stem cells and their derivatives (e.g., exosomes) are an emerging and encouraging field in diagnosing and treating neurodegenerative diseases. Although stem cell therapies have been successful in animal models, numerous clinical trials in AD patients have yielded unpromising results, which we will further discuss.

scholarly journals New Prospects for Stem Cell Therapy in Alzheimer’s Disease

2021 ◽  
Author(s):  
Kun Jiang ◽  
Yongqi Zhu ◽  
Lei Zhang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Stem Cell Therapy ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Therapy Strategies

Alzheimer’s disease (AD) is a kind of neurodegenerative disease with insidious onset and progressive progression. The etiology of AD may be related to the loss of neurons, astrocytes, and microglial in the nervous system. Exogenous stem cell transplantation has brought hope to the treatment of AD. Stem cell transplantation can reduce amyloid β-protein (Aβ) deposition and Tau phosphorylation, and provide secretory factor support to improve learning and memory deficits. The purpose of this review is to provide an overview of the relationship between different stem cell species and the treatment of AD, and also summarize current experimental stem cell therapy strategies and their potential clinical applications in the future.

scholarly journals Neural Stem Cells Therapy to Treat Neurodegenerative Diseases

2021 ◽  
Vol 271 ◽  
pp. 03076
Author(s):  
Weibai Chen
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Neural Stem Cells ◽  
Neurodegenerative Diseases ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
The Body ◽  
Brain Diseases ◽  
The Brain

Neural stem cells have the ability to proliferation, differentiate and renew, which plays an important role in the growth, maturation and senescence of the human brain. But according to researches, neural stem cells in the brain do not remain active throughout an organism's lifetime. Many neural stem cells become dormant when the brain matures, and may be activated when the body is sick to selectively heal the disease. In recent years, there are many studies on neural stem cells. Joshua[1] and Ting Zhang[2] show that neurodegenerative diseases such as ischemic stroke, Alzheimer's disease and Parkinson's disease can be improved by the transplantation of neural stem cells, however the specific mechanism is not clear. This paper investigates three main questions: Why neural stem cell transplantation is chosen as a treatment? Where does NSCs derive from in clinical transplantation? How does neural stem cell transplantation treat brain diseases? And we also figure out the answers to these three questions. Firstly, transplantation of hypothalamic NSCs can delay the process of aging in the host, and Chemokines and EVs which secreted by neural stem cells can delay aging and defend neurodegenerative diseases. Secondly, the sources of NSCs can be divided into three types. The first is to isolate NSCs from primary tissue and cultivate them in vitro. The second is to produce the required cells by inducing pluripotent stem cells and embryonic stem cells. The third way to get NCS is through transdifferentiation of somatic cells. Thirdly, in brain diseases, transplanted NSCs can migrate from the aggregation site to the site of the disease, reducing damage to the blood-brain barrier, repairing learning and memory abilities that depend on the hippocampus and secreting neurotrophic factors.

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