Investigation of the thermodynamic and physicochemical properties of lavender oil (Lavandula angustifolia Mill.)-ethanol-water system

The thermodynamic and physicochemical properties of lavender oil (Lavandula angustifolia Mill.)-ethanol-water system were measured. The chemical composition of solutions of the lavender oil in 70%, 75%, 80%, 85%, 90%, and 95% ethanol was determined using GC/MS analysis. The main compounds in the solutions are oxygenated monoterpenes (β-linalool, terpinen-4-ol, α-terpineol, and linalyl acetate), followed by monoterpene hydrocarbons ((Z)-β-ocimene and (E)-β-ocimene), and sesquiterpene hydrocarbons (β-caryophyllene and (E)-β-farnesene). The ternary phase diagrams were constructed. By multiply linear regression model for surface tension prediction was applied. The thermodynamic and kinetic parameters of lavender oil – ethanol - water system were calculated (energy of Gibb’s, enthalpy, entropy, energy of activation, and coefficient of diffusion).

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Physicochemical properties, binary and ternary phase diagrams of ketoprofen

Chirality ◽

10.1002/chir.20075 ◽

2004 ◽

Vol 16 (8) ◽

pp. 541-548 ◽

Cited By ~ 15

Author(s):

Ying Hong Lu ◽

Chi Bun Ching

Keyword(s):

Physicochemical Properties ◽

Phase Diagrams ◽

Ternary Phase ◽

Ternary Phase Diagrams

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Prophylactic Application of Lavandula Angustifolia Mill. Oil and Its Active Component Linalyl Acetate Alleviate Comorbidity and Exacerbation Risk in Rats With Collagen-Induced Arthritis Accompanied by Chronic Nicotine-Induced Hypertension.

10.21203/rs.3.rs-127467/v1 ◽

2020 ◽

Author(s):

Eunhye Seo ◽

Yu Shan Hsieh ◽

Jeong-Min Lee ◽

You Kyoung Shin ◽

Geun Hee Seol

Keyword(s):

Skeletal Muscle ◽

Gastrocnemius Muscle ◽

Endothelial Damage ◽

Vascular Endothelial ◽

Paw Edema ◽

Linalyl Acetate ◽

Collagen Induced Arthritis ◽

Lavandula Angustifolia ◽

Lavender Oil ◽

Chronic Nicotine

Abstract Background: Hypertension (HTN) in rheumatoid arthritis (RA) is more common in smokers than in non-smokers, increasing the risks of cardiovascular and skeletal muscle related comorbidities, but studies on pharmacological protection strategies are insufficient. Lavandula angustifolia Mill. (lavender) oil has traditionally been used for RA and HTN via its anti-inflammatory properties. This study aimed to investigate the effects of lavender oil and its main component linalyl acetate on cardiovascular and skeletal muscle protection in a rat model of RA with chronic nicotine-induced HTN. Methods: Collagen-induced arthritis (CIA), with or without chronic nicotine-induced HTN, were induced in Sprague-Dawley rats. Lavender or linalyl acetate (10 or 100 mg/kg/day) were administrated intraperitoneally to CIA plus chronic nicotine-induced HTN (H-CIA) rats. The effects of lavender and linalyl acetate was evaluated by measurement of hind paw thickness, body weight, blood pressure (BP), serum concentrations of interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1). In addition to above, histological analysis of thoracic aorta and gastrocnemius muscle were used. Results: BP was significantly higher, vascular endothelium more deteriorated and paw edema more severe in H-CIA than in CIA. Both groups showed clear signs of skeletal muscle atrophy and inflammation, but gastrocnemius muscle weight was lower and muscle inflammatory status worse in H-CIA than in CIA. Reduced mitochondrial function was observed only in H-CIA. Prophylactic application of 100 mg/kg lavender oil or linalyl acetate kept IL-6 levels to the normal range and reduced hind paw edema and systolic BP. Linalyl acetate 100 mg/kg was the only treatment that maintained diastolic BP and IGF-1 in their normal ranges and prevented vascular endothelial damage. These treatments also reduced inflammation of the gastrocnemius muscle and inhibited mitochondrial dysfunction while tending to increase muscle mass. Conclusions: Chronic nicotine exposure induces defects that increase the risks of cardiovascular disease and muscle weakness, and application of lavender and linalyl acetate reduced the risks, especially, linalyl acetated alleviated vascular endothelial damage along with maintained IGF-1 level. Current results encourage smokers at high risk for RA to quit smoking, and further suggest that linalyl acetate is a useful agent to prevent cardiovascular and skeletal muscle related comorbidities.

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Physicochemical and thermodynamic properties of solutions of clary sage (Salvia sclarea L.) essential oil in ethanol-water system

E3S Web of Conferences ◽

10.1051/e3sconf/202020701021 ◽

2020 ◽

Vol 207 ◽

pp. 01021

Author(s):

Stanislava Tasheva ◽

Vanya Gandova ◽

Krasimira Dobreva ◽

Vanya Prodanova-Stefanova ◽

Krasimira Marinova ◽

...

Keyword(s):

Surface Tension ◽

Refractive Index ◽

Chemical Composition ◽

Essential Oil ◽

Thermodynamic Properties ◽

Ternary Phase ◽

Water System ◽

Surface Tension Data ◽

Ternary Phase Diagrams ◽

Salvia Sclarea

Clary sage (Salvia sclarea L.) essential oil-ethanol-water system was investigated. The surface tension, density and refractive index of clary sage essential oil + ethanol (70%, 75%, 80%, 85%, 90%, and 95%) solutions were measured. The chemical composition of solutions (ratio 1:5, 1:6, and 1:7) was determined using GC/MS analysis. According the experimental results ternary phase diagrams were constructed. Comparative revue between experimental and calculated surface tension data was done. After analyses good correlation between two surface tension values was observed

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