scholarly journals Toward a quantum-enhanced strontium optical lattice clock at INRIM

2020 ◽  
Vol 230 ◽  
pp. 00011
Author(s):  
Marco G. Tarallo

The new strontium atomic clock at INRIM seeks to establish a new frontier in quantum measurement by joining state-of-the-art optical lattice clocks and the quantized electromagnetic field provided by a cavity QED setup. The goal of our experiment is to apply advanced quantum techniques to state-of-the-art optical lattice clocks, demonstrating enhanced sensitivity while preserving long coherence times and the highest accuracy. In this paper we describe the current status of the experiment and the prospected sensitivity gain for the designed cavity QED setup.

2011 ◽  
Author(s):  
Masami Yasuda ◽  
Takuya Kohno ◽  
Kazumoto Hosaka ◽  
Hajime Inaba ◽  
Yoshiaki Nakajima ◽  
...  

2013 ◽  
Vol 63 (4) ◽  
pp. 883-889 ◽  
Author(s):  
Dai-Hyuk Yu ◽  
Chang Yong Park ◽  
Won-Kyu Lee ◽  
Sangkyung Lee ◽  
Sang Eon Park ◽  
...  

2021 ◽  
Vol 22 (3) ◽  
pp. 1244
Author(s):  
Anna Yang ◽  
Boris Kantor ◽  
Ornit Chiba-Falek

Alzheimer’s disease (AD) has a critical unmet medical need. The consensus around the amyloid cascade hypothesis has been guiding pre-clinical and clinical research to focus mainly on targeting beta-amyloid for treating AD. Nevertheless, the vast majority of the clinical trials have repeatedly failed, prompting the urgent need to refocus on other targets and shifting the paradigm of AD drug development towards precision medicine. One such emerging target is apolipoprotein E (APOE), identified nearly 30 years ago as one of the strongest and most reproduceable genetic risk factor for late-onset Alzheimer’s disease (LOAD). An exploration of APOE as a new therapeutic culprit has produced some very encouraging results, proving that the protein holds promise in the context of LOAD therapies. Here, we review the strategies to target APOE based on state-of-the-art technologies such as antisense oligonucleotides, monoclonal antibodies, and gene/base editing. We discuss the potential of these initiatives in advancing the development of novel precision medicine therapies to LOAD.


Nature ◽  
2016 ◽  
Vol 542 (7639) ◽  
pp. 66-70 ◽  
Author(s):  
S. Kolkowitz ◽  
S. L. Bromley ◽  
T. Bothwell ◽  
M. L. Wall ◽  
G. E. Marti ◽  
...  

2006 ◽  
Vol 97 (17) ◽  
Author(s):  
A. V. Taichenachev ◽  
V. I. Yudin ◽  
V. D. Ovsiannikov ◽  
V. G. Pal’chikov

2021 ◽  
Vol 15 (4) ◽  
Author(s):  
R.J. Fasano ◽  
Y.J. Chen ◽  
W.F. McGrew ◽  
W.J. Brand ◽  
R.W. Fox ◽  
...  

MAPAN ◽  
2012 ◽  
Vol 27 (1) ◽  
pp. 9-12
Author(s):  
Tetsuya Ido

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