Selection of photosensitisers for photodynamic therapy of cancer using time-resolved photothermal spectroscopy

The article provides an overview of the use of photodynamic therapy for photodamage of the skin. The causes, pathogenesis and clinical manifestations of skin photodamage are considered. The definition, principle of action of photodynamic therapy, including the sources of light used, the classification of photosensitizers and their main characteristics are given. Analyzed studies that show the effectiveness and comparative evaluation in the selection of various light sources and photosensitizing agents for photodynamic therapy in patients with clinical manifestations of photodamage.

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Theranostics Based on Iron Oxide and Gold Nanoparticles for Imaging- Guided Photothermal and Photodynamic Therapy of Cancer

Current Topics in Medicinal Chemistry ◽

10.2174/1568026617666161122120537 ◽

2017 ◽

Vol 17 (16) ◽

pp. 1858-1871 ◽

Cited By ~ 14

Author(s):

S. Rajkumar ◽

M. Prabaharan

Keyword(s):

Gold Nanoparticles ◽

Photodynamic Therapy ◽

Iron Oxide ◽

Photodynamic Therapy Of Cancer

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“Stealth” dendrimers with encapsulation of indocyanine green for photothermal and photodynamic therapy of cancer

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2021.120502 ◽

2021 ◽

Vol 600 ◽

pp. 120502 ◽

Cited By ~ 2

Author(s):

Tianming Cui ◽

Shukai Li ◽

Shengfu Chen ◽

Ying Liang ◽

Haotian Sun ◽

...

Keyword(s):

Photodynamic Therapy ◽

Indocyanine Green ◽

Photodynamic Therapy Of Cancer

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Synthesis, Tumor Specificity, and Photosensitizing Efficacy of Erlotinib-Conjugated Chlorins and Bacteriochlorins: Identification of a Highly Effective Candidate for Photodynamic Therapy of Cancer

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01735 ◽

2021 ◽

Author(s):

Ravindra R. Cheruku ◽

Joseph Cacaccio ◽

Farukh A. Durrani ◽

Walter A. Tabaczynski ◽

Ramona Watson ◽

...

Keyword(s):

Photodynamic Therapy ◽

Photodynamic Therapy Of Cancer ◽

Highly Effective ◽

Tumor Specificity

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Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances

Pharmaceuticals ◽

10.3390/ph14070603 ◽

2021 ◽

Vol 14 (7) ◽

pp. 603

Author(s):

Vanesa Pérez-Laguna ◽

Isabel García-Luque ◽

Sofía Ballesta ◽

Antonio Rezusta ◽

Yolanda Gilaberte

Keyword(s):

Photodynamic Therapy ◽

Soft Tissues ◽

Combined Treatment ◽

Resistance Pattern ◽

Antimicrobial Photodynamic Therapy ◽

Antimicrobial Drugs ◽

Bacteria And Fungi ◽

High Level ◽

Selection Of

The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult.

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