Association of Waist Circumference and Body Mass Index With All-Cause Mortality in CKD: The REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study

In this study based on a large nationally representative sample of Korean adults, we investigated the potential associations of the body mass index (BMI) and waist circumference (WC) with mortality in patients undergoing hemodialysis. We obtained the data of 18,699 participants >20 years of age who were followed up with for 4 years and for whom BMI and WC information were available, using a nationally representative dataset from the Korean National Health Insurance System. Patients were stratified into five levels by their baseline BMI and into six levels by their WC (5-cm increments). A total of 4975 deaths occurred during a median follow-up period of 48.2 months. Participants with a higher BMI had a lower mortality rate than those with a lower BMI. In a fully adjusted Cox regression analysis, being overweight and obese was associated with a significantly lower relative risk of all-cause mortality relative to the reference group. Conversely, the mortality rate was higher among participants with a high WC than among those with a low WC. Participants with the highest WC had a higher risk of mortality, while those with the lowest WC level had a significantly lower risk of mortality. In conclusion, all-cause mortality was positively associated with WC, a measure of abdominal obesity, and inversely associated with BMI, a measure of body volume, in patients undergoing hemodialysis.

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2105-P: Waist Circumference and All-Cause Mortality Independent of Body Mass Index in Korean Population from the National Health Insurance Health Checkup, 2009-2015

Diabetes ◽

10.2337/db19-2105-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 2105-P

Author(s):

YANG-HYUN KIM ◽

SOON JIB YOO ◽

SEONG-SU LEE

Keyword(s):

Body Mass Index ◽

Health Insurance ◽

Waist Circumference ◽

Body Mass ◽

National Health Insurance ◽

National Health ◽

Korean Population ◽

Health Checkup ◽

All Cause Mortality

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Effects of waist to height ratio, waist circumference, body mass index on the risk of chronic diseases, all-cause, cardiovascular and cancer mortality

Postgraduate Medical Journal ◽

10.1136/postgradmedj-2020-137542 ◽

2020 ◽

pp. postgradmedj-2020-137542 ◽

Cited By ~ 1

Author(s):

Kenneth Lo ◽

Yu-Qing Huang ◽

Geng Shen ◽

Jia-Yi Huang ◽

Lin Liu ◽

...

Keyword(s):

Body Mass Index ◽

Waist Circumference ◽

Chronic Diseases ◽

Body Mass ◽

Cancer Mortality ◽

Cardiometabolic Health ◽

Height Ratio ◽

All Cause Mortality ◽

Waist To Height Ratio ◽

Obesity Indices

BackgroundGiven the fat redistribution in later stages of life, how the associations between abdominal obesity and the risk of morbidity and mortality have changed with age have not been elucidated, especially for waist to height ratio (WHtR).ObjectiveTo compare the strength of association between obesity indices and chronic diseases at baseline, and the subsequent mortality risk among US adults.MethodsWe included 21 109 participants from National Health and Nutrition Examination Survey 1999–2014. We performed logistic regression and receiver operating curve analysis to examine the discriminatory power of obesity indicators on cardiometabolic diseases and cancer at baseline. Sex-stratified and age-stratified Cox models were constructed to explore the prospective association between obesity indices and all-cause, cardiovascular and cancer mortality.ResultsElevated WHtR, elevated waist circumference (WC) and body mass index (BMI)-classified obesity are associated with higher odds of hypertension (OR: 1.37-2.13), dyslipidemia (OR: 1.06 to 1.75, all p<0.05) and diabetes (OR: 1.40-3.16, all p<0.05). WHtR had significantly better discriminatory power to predict cardiometabolic health than BMI, especially for diabetes (area under the curve: 0.709 vs 0.654). After multivariable adjustment, all obesity indicators are associated with lower risk of all-cause mortality among females aged ≥65 years (HR: 0.64 to 0.85), but the association was only significant for BMI when obesity indicators were mutually adjusted (HR: 0.79).ConclusionsWHtR and WC appeared to be the better indicators for cardiometabolic health than BMI. However, BMI had a stronger and inverse association with a greater risk of all-cause mortality among older females.

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A comparison of body mass index, waist–hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study

International Journal of Obesity ◽

10.1038/sj.ijo.0801787 ◽

2001 ◽

Vol 25 (11) ◽

pp. 1730-1735 ◽

Cited By ~ 243

Author(s):

TLS Visscher ◽

JC Seidell ◽

A Molarius ◽

D van der Kuip ◽

A Hofman ◽

...

Keyword(s):

Body Mass Index ◽

Waist Circumference ◽

Body Mass ◽

The Elderly ◽

Rotterdam Study ◽

Waist Hip Ratio ◽

All Cause Mortality

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Waist Circumference and All-Cause Mortality Independent of Body Mass Index in Korean Population from the National Health Insurance Health Checkup 2009–2015

Journal of Clinical Medicine ◽

10.3390/jcm8010072 ◽

2019 ◽

Vol 8 (1) ◽

pp. 72 ◽

Cited By ~ 2

Author(s):

Yang-Hyun Kim ◽

Seon Kim ◽

Kyung-Do Han ◽

Jin-Hyung Jung ◽

Seong-Su Lee ◽

...

Keyword(s):

Body Mass Index ◽

Health Insurance ◽

Waist Circumference ◽

Body Mass ◽

National Health Insurance ◽

National Health ◽

Normal Weight ◽

Health Checkup ◽

All Cause Mortality ◽

Level 3

Background: Waist circumference (WC) is an index of abdominal obesity and associated with co-morbidities and mortality. Higher WC is positively associated with increased mortality; therefore, we examined the relationship between WC and mortality in Korean populations with the interaction of body mass index (BMI) and WC for mortality. Methods: A total of 23,263,878 subjects (men = 11,813,850 and women = 11,450,028) who were older than 20 years and underwent the National Health Insurance Service health checkup were included. WC was divided into six categories by 5 cm increments and level 3 (85–90 cm in men and 80–85 cm in women) was referenced. Multivariable Cox proportional hazard models were used to obtain the hazard ratios (HRs) and 95% confidence intervals for all-cause mortality according to the six levels of WC. Results: WC in 5 cm increments showed a positively increased all-cause mortality after adjusting for all covariates including BMI. Men showed higher HRs for mortality than women as WC increased, and the HRs were higher in the lower WC levels, but lower in the higher WC levels among the subjects aged 65–85 years than subjects aged 40–65 years. Even in subjects with normal weight and overweight, increased WC (levels 4, 5, and 6) showed increased HRs for mortality (HRs = 1.156, 1.412, and 1.614 in normal BMI and 1.145, 1.401, and 1.909 in overweight, respectively). Conclusion: There was a linear association between WC and all-cause mortality across all BMI categories even in the subjects with normal or overweight BMI. Physicians should check WC routinely even in the subjects with normal weight or overweight.

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