Thrombolysis for acute ischemic stroke: Future directions

2001 ◽  
Vol 1 (2) ◽  
pp. 176-190
Author(s):  
James F. Meschia ◽  
Thomas G. Brott
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Future Directions

Future directions for recanalization therapy in acute ischemic stroke

2006 ◽  
Vol 1 (1) ◽  
pp. 107-116 ◽  
Author(s):  
Joshua Willey ◽  
H Christian Schumacher ◽  
Philip M Meyers
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Future Directions

Future directions for endovascular management of patients with acute ischemic stroke

2014 ◽  
Vol 41 (3) ◽  
pp. 151-152 ◽  
Author(s):  
Laurent Pierot ◽  
Azzedine Benaissa ◽  
Vitor Pereira ◽  
Karl-Olof Lövblad
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Endovascular Management ◽  
Future Directions

scholarly journals Tandem Carotid Lesions in Acute Ischemic Stroke: Mechanisms, Therapeutic Challenges, and Future Directions

2020 ◽  
Vol 41 (7) ◽  
pp. 1142-1148 ◽  
Author(s):  
A.Y. Poppe ◽  
G. Jacquin ◽  
D. Roy ◽  
C. Stapf ◽  
L. Derex
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Future Directions

Oxidative Stress in the Pathogenesis of Alzheimer’s Disease and Cerebrovascular Disease with Therapeutic Implications

2020 ◽  
Vol 19 (2) ◽  
pp. 94-108 ◽  
Author(s):  
Anamaria Jurcau ◽  
Aurel Simion
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Preventive Measures ◽  
Current Knowledge ◽  
Antioxidant Treatment ◽  
Future Directions ◽  
Therapeutic Implications

The significant gain in life expectancy led to an increase in the incidence and prevalence of dementia. Although vascular risk factors have long and repeatedly been shown to increase the risk of Alzheimer’s Disease (AD), translating these findings into effective preventive measures has failed. In addition, the finding that incident ischemic stroke approximately doubles the risk of a patient to develop AD has been recently reinforced. Current knowledge and pathogenetic hypotheses of AD are discussed. The implication of oxidative stress in the development of AD is reviewed, with special emphasis on its sudden burst in the setting of acute ischemic stroke and the possible link between this increase in oxidative stress and consequent cognitive impairment. Current knowledge and future directions in the prevention and treatment of AD are discussed outlining the hypothesis of a possible beneficial effect of antioxidant treatment in acute ischemic stroke in delaying the onset/progression of dementia.

scholarly journals Thrombus Composition, Imaging, and Outcome Prediction in Acute Ischemic Stroke

Neurology ◽  
2021 ◽  
Vol 97 (20 Supplement 2) ◽  
pp. S68-S78
Author(s):  
Raed A. Joundi ◽  
Bijoy K. Menon
Keyword(s):  
Ischemic Stroke ◽  
Acute Stroke ◽  
Acute Ischemic Stroke ◽  
Outcome Prediction ◽  
Imaging Techniques ◽  
Future Directions ◽  
Endovascular Thrombectomy ◽  
Imaging Characteristics ◽  
Multiple Domains ◽  
The Relationship

Background and ObjectivesNew imaging techniques have advanced our ability to capture thrombus characteristics and burden in real time. An improved understanding of recanalization rates with thrombolysis and endovascular thrombectomy based on thrombus characteristics has spurred interest in new therapies for acute stroke.Methods and ResultsThis article reviews the biochemical, structural, and imaging characteristics of intracranial thrombi in acute ischemic stroke; the relationship between thrombus composition and response to lytic and endovascular therapies; and current and future directions for improving outcomes in patients with acute stroke based on thrombus characteristics.DiscussionThrombus composition, size, location, and timing from stroke onset correlate with imaging findings in acute ischemic stroke and are associated with clinical outcome. Further research across multiple domains could assist in better applying our knowledge of thrombi to patient selection and individualization of acute therapies.

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