Antiarrhythmika: Welche Rolle spielen sie heute noch?

2020 ◽  
Vol 145 (08) ◽  
pp. 526-535
Author(s):  
Thomas H Fischer
Keyword(s):  
Ventricular Arrhythmias ◽  
Beta Blockers ◽  
Antiarrhythmic Therapy ◽  
Term Therapy ◽  
Acute Therapy ◽  
Cardiac Arrythmias ◽  
Antiarrhythmic Medication ◽  
Long Term Therapy

AbstractThe use of medical antiarrhythmic therapy apart from beta-blockers has been steadily decreasing in the recent past. This can partly be attributed to technological progress that has rendered the ablation of complex cardiac arrhythmias like atrial fibrillation, focal atrial tachycardias and ventricular arrhythmias feasible and efficacious. Furthermore, an awareness regarding pro-arrhythmic and toxic side-effects of antiarrhythmic medication has evolved. Nevertheless, medical antiarrhythmic therapy still plays a fundamental role in acute therapy of arrythmias as well as certain indications for long-term therapy. This review comprehensively summarizes the current role of medical antiarrhythmic therapy in daily clinical practice focusing on mechanisms and therapies of the most common cardiac arrythmias.

scholarly journals The role of diuretics in the treatment of hypertension: a focus on chlorthalidone (lecture)

HYPERTENSION ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 12-29
Author(s):  
Yu.M. Sirenko
Keyword(s):  
Cardiovascular Complications ◽  
Term Therapy ◽  
Thiazide Diuretics ◽  
Cerebrovascular Complications ◽  
Hypertension Therapy ◽  
Long Term Therapy ◽  
The Impact ◽  
Therapy Of Hypertension

The lecture discusses the role of thiazide and thiazide-like diuretics, in particular chlorthalidone, in the modern treatment of arterial hypertension. The modern concepts about the mechanism of action of thiazide diuretics and chlorthalidone are presented. Differences in the degree of antihypertensive effect of hydrochlorothiazide and chlorthalidone are discussed. The results of large randomized trials SHEP, MRFIT, ALLHAT were analyzed, in which chlorthalidone therapy significantly reduced the risk of developing cardiovascular and cerebrovascular complications of hypertension. The effect of thiazide diuretics on glucose metabolism and the impact of carbohydrate metabolism disorders during treatment with chlorthalidone on the risk of cardiovascular complications was considered. The lecture also discusses the effect of chlorthalidone therapy on kidney function, the possibility of its use in chronic kidney disease. The data are presented on the prevention of resistant hypertension and chro-nic heart failure during long-term therapy of hypertension with chlorthalidone. The frequency and terms of the development of side effects of hypertension therapy with thiazide-like diuretics were also analyzed.

Immunoregulation of Autoimmune Disorders: The Role of Intravenous Immunoglobulins

1993 ◽  
Vol 16 (5_suppl) ◽  
pp. 189-195 ◽  
Author(s):  
G. Luzi ◽  
R. Ferrara
Keyword(s):  
Hematologic Malignancies ◽  
Intravenous Immunoglobulins ◽  
Term Therapy ◽  
Immune Modulators ◽  
Bacterial Diseases ◽  
Immunoglobulin Preparations ◽  
Original Observation ◽  
Long Term Therapy

Modified and intact immunoglobulin preparations are available for therapeutic use. The administration of intravenous immunoglobulins (IVI G) gave positive results in Primary Immunodeficiency Syndromes (PIS) (prophylaxis of viral and bacterial diseases), in treatment of secondary immunodeficiencies (hematologic malignancies, bone marrow transplantation), and in some infections. Adverse reactions have been reported during IVIG infusions, but they are rarely serious and do not represent limiting conditions for a short or long term therapy. After the original observation in thrombocytopenic purpura, IVIG have been used as immune modulators in various autoimmune related disorders. Various mechanisms of action are proposed: blockade and down regulation of phagocytic function via Fc receptor, regulation of idiotype-anti idiotype network, suppression of idiotype synthesis, T-B cell interference towards antigen presentation, increase in suppressor lymphocytes, IVIG-cytokine interaction.

scholarly journals Sustained hemodynamic improvement during long-term therapy with levodopa in heart failure: Role of plasma catecholamines

1987 ◽  
Vol 10 (6) ◽  
pp. 1286-1293 ◽  
Author(s):  
Sol I. Rajfer ◽  
James D. Rossen ◽  
John W. Nemanich ◽  
Frank L. Douglas ◽  
Fetima Davis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Plasma Catecholamines ◽  
Term Therapy ◽  
Hemodynamic Improvement ◽  
Long Term Therapy

scholarly journals Managing treatment fatigue in patients with multiple sclerosis on long-term therapy: the role of multiple sclerosis nurses

2014 ◽  
pp. 1093 ◽  
Author(s):  
Robert Ristuccia ◽  
Jewell Sally ◽  
Ann Crawford ◽  
Holly Mara ◽  
Laura McCatty ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Term Therapy ◽  
Long Term Therapy

Anxiolytics in the Treatment of Behavioral and Psychological Symptoms of Dementia

2000 ◽  
Vol 12 (S1) ◽  
pp. 281-289 ◽  
Author(s):  
Hervé Allain ◽  
Stéphane Schück ◽  
Danièle Bentué-Ferrer ◽  
Michel Bourin ◽  
Martine Vercelletto ◽  
...  
Keyword(s):  
Psychological Symptoms ◽  
Behavioral Therapy ◽  
Term Therapy ◽  
Drug Classes ◽  
Advanced Stages ◽  
Emergency Measure ◽  
Long Term Therapy ◽  
Behavioral And Psychological Symptoms

By definition, anxiolytics are drugs capable of treating anxiety and anxiety related disorders. The precise role of anxiolytics, particularly in comparison with other drug classes (e.g., antipsychotics and antidepressants) and other therapeutic approaches (e.g., psychotherapy, behavioral therapy, and relaxation) in treating behavioral and psychological symptoms of dementia (BPSD) needs to be determined. If anxiolytics are used for BPSD, the clinician must decide whether they should be used as an emergency measure, as long-term therapy, or both. Also, whether anxiolytics are useful in treating anxiety and its consequences in both the early and advanced stages of dementia must be considered.

scholarly journals Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
George Mwandia ◽  
Hari Polenakovik
Keyword(s):  
High Performance ◽  
Sensory Neuropathy ◽  
Multidrug Resistant ◽  
Term Therapy ◽  
Solid Organ ◽  
Chromatography Analysis ◽  
Hypoxic Respiratory Failure ◽  
Long Term Therapy

We describe a rare infection with Nocardia spp. (N. pseudobrasiliensis species identification based on high-performance liquid chromatography analysis) in a 68-year-old renal transplant recipient. He presented with pneumonia complicated by hypoxic respiratory failure. He was allergic to sulphonamides. He was initially successfully treated with linezolid. However, he suffered severe sensory neuropathy after 4 months of therapy, necessitating linezolid cessation and completion of treatment with azithromycin. He had clinical and radiological resolution of his pneumonia and was disease free at subsequent follow-up 4 years later. This case highlights the need for alternative therapies for nocardiosis for patients that cannot be treated with sulphonamides due to allergies or/and infection with multidrug-resistant pathogens. It also illustrates the treatment limiting side effects of long-term therapy with linezolid.

scholarly journals The role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications

2010 ◽  
Vol 13 (3) ◽  
pp. 14-19 ◽  
Author(s):  
Marina Vladimirovna Shestakova
Keyword(s):  
Direct Synthesis ◽  
Visceral Obesity ◽  
Vascular Wall ◽  
Term Therapy ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Leading Role ◽  
Long Term Therapy

Renin-angiotensin-aldosterone system (RAAS) is a major system of the human body playing a key role in the regulation of most physiological andpathological conditions, such as vascular tone, AD level, myocardial and vascular wall remodeling, development of atherosclerosis, glomerulosclerosis,and other pathologies. The discovery of local (tissue) RAAS in the late XX century gave evidence of direct synthesis of all components of this system,from renin to aldosterone, in target tissues and organs. Activation of tissue RAAS was shown to play a leading role in the evolvement of diabetic complicationsincluding cardiovascular diseases, diabetic nephropathy (DN), and retinopathy. Recent studies revealed the presence of RAAS componentsin fat and pancreas. This system is involved in the development of visceral obesity, pre-diabetes, and Type 2 diabetes. These findings are confirmedby a reduced risk of CDM2 in subjects receiving long-term therapy with RAAS blockers.

scholarly journals Neuro-Oncology Practice Clinical Debate: long-term antiepileptic drug prophylaxis in patients with glioma

2020 ◽  
Vol 7 (6) ◽  
pp. 583-588
Author(s):  
Brian Stocksdale ◽  
Seema Nagpal ◽  
John D Hixson ◽  
Derek R Johnson ◽  
Prashant Rai ◽  
...  
Keyword(s):  
Standard Of Care ◽  
Term Therapy ◽  
Tumor Patients ◽  
Oncology Practice ◽  
Long Term Therapy ◽  
First Time ◽  
Drug Prophylaxis

Abstract Patients with primary brain tumors often experience seizures, which can be the presenting symptom or occur for the first time at any point along the illness trajectory. In addition to causing morbidity, seizures negatively affect independence and quality of life in other ways, for example, by leading to loss of driving privileges. Long-term therapy with antiepileptic drugs (AEDs) is the standard of care in brain tumor patients with seizures, but the role of prophylactic AEDs in seizure-naive patients remains controversial. In this article, experts in the field discuss the issues of AED efficacy and toxicity, and explain their differing recommendations for routine use of prophylactic AEDs.

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