scholarly journals The role of diuretics in the treatment of hypertension: a focus on chlorthalidone (lecture)

HYPERTENSION ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 12-29
Author(s):  
Yu.M. Sirenko
Keyword(s):  
Cardiovascular Complications ◽  
Term Therapy ◽  
Thiazide Diuretics ◽  
Cerebrovascular Complications ◽  
Hypertension Therapy ◽  
Long Term Therapy ◽  
The Impact ◽  
Therapy Of Hypertension

The lecture discusses the role of thiazide and thiazide-like diuretics, in particular chlorthalidone, in the modern treatment of arterial hypertension. The modern concepts about the mechanism of action of thiazide diuretics and chlorthalidone are presented. Differences in the degree of antihypertensive effect of hydrochlorothiazide and chlorthalidone are discussed. The results of large randomized trials SHEP, MRFIT, ALLHAT were analyzed, in which chlorthalidone therapy significantly reduced the risk of developing cardiovascular and cerebrovascular complications of hypertension. The effect of thiazide diuretics on glucose metabolism and the impact of carbohydrate metabolism disorders during treatment with chlorthalidone on the risk of cardiovascular complications was considered. The lecture also discusses the effect of chlorthalidone therapy on kidney function, the possibility of its use in chronic kidney disease. The data are presented on the prevention of resistant hypertension and chro-nic heart failure during long-term therapy of hypertension with chlorthalidone. The frequency and terms of the development of side effects of hypertension therapy with thiazide-like diuretics were also analyzed.

scholarly journals What is the impact of methotrexate on liver in patients with juvenile idiopathic arthritis? Results of liver SWE performed in a single centre

2021 ◽  
Author(s):  
Vildan Güngörer ◽  
Mehmet Öztürk ◽  
Mustafa Yasir Özlü ◽  
Şükrü Arslan
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Shear Wave Elastography ◽  
Term Therapy ◽  
Control Group ◽  
Significant Difference ◽  
Group 2 ◽  
Long Term Therapy ◽  
And Control ◽  
The Impact

ABSTRACT Objectives Long-term therapy with low-dose methotrexate (MTX) is widely used in treatment of rheumatic diseases, in children. The purpose of this study was to evaluate liver elasticity in patients with juvenile idiopathic arthritis (JIA) who received MTX and compare the results with control group. Methods Liver elasticity was evaluated with shear wave elastography (SWE) technique in 25 patients aged 3–17 years who were followed up with JIA and received MTX and compared with 25 healthy controls of the same age and weight. Factors that had an effect on liver elasticity were examined. Results The mean SWE value of patients was 2.64 ± 2.13 m/s and 24.10 ± 18.50 kPa, whereas 1.83 ± 0.16 m/s and 10.09 ± 1.83 kPa in control group. There was a significant difference in liver elasticity in the patient and control groups. When the patients were evaluated as Group 1 (< 1000 mg) and Group 2 (≥ 1000 mg) according to the cumulative MTX dose, no significant difference was obtained. There was positive correlation between liver elasticity and weekly MTX dose and age. Conclusions Our study revealed that liver elasticity significantly decreased in patients who received MTX when compared with the control group. The elastography technique will be understood better over time and used safely in many areas.

scholarly journals Central, peripheral, and renal hemodynamics in patients with hypertensive disease during long-term monotherapy with enalapril alone and in combination with hydrochlorothiazide (according to the data of RU-003 study)

2004 ◽  
Vol 10 (1) ◽  
pp. 19-22
Author(s):  
A. O. Konradi ◽  
R. Kh. Afaunov ◽  
O. V. Mamontov ◽  
A. A. Pushkarev ◽  
A. N. Krutikov ◽  
...  
Keyword(s):  
Time Course ◽  
Combined Therapy ◽  
Blood Flow Rate ◽  
Renal Hemodynamics ◽  
Term Therapy ◽  
Hypertensive Disease ◽  
The Status ◽  
Long Term Therapy ◽  
The Impact

The study was undertaken to examine the impact of long-term therapy with enapril alone and in its fixed combination with hydrochlorothiazide (renitec/co-renitec, MSD) on the time course of changes in central, peripheral, and renal hemodynamic parameters and on the status of cardiopulmonary reflex in patients with hypertensive disease. The study included 35 patients with Stages I-II arterial hypertension. Therapy with renitec/co-renitec was performed for 6 months, starting with its dose of 10 mg, followed by titration up to 40 mg and switching to a combined therapy. A decrease in blood pressure in the groups of patients receiving therapy with enalapril alone and in combination with hydrochlorothiazide was found to be associa ted mainly with diminished peripheral vascular resistance, which was followed by a higher volume blood flow rate in the forearm-and a better sensitivity of the cardiopulmonary baroreflex. Moreover, long-term use of enalapril both alone and in combination with thiazide diuretic was attended by improved renal hemodynamics.

scholarly journals A Randomized Open Clinical Study of the Atherosclerosis Treatment Information Video Effect on Adherence to Long-Term Therapy in Patients with Cardiovascular Diseases

2021 ◽  
Vol 17 (5) ◽  
pp. 683-687
Author(s):  
Yu. V. Bulaeva ◽  
E. A. Naumova ◽  
O. N. Semenova ◽  
T. V. Kanaeva ◽  
K. A. Popov ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Patient Adherence ◽  
Intervention Group ◽  
Cardiovascular Complications ◽  
The Body ◽  
Term Therapy ◽  
Control Group ◽  
Treatment Information ◽  
Long Term Therapy

Aim. Study the effect of a study video, which was created by researchers and devoted to the atherosclerosis development and the effect of statin therapy on atherosclerotic plaque, on adherence to long-term therapy in patients with high or very high risk of cardiovascular complications.Material and methods. 120 patients admitted to hospital with cardiovascular diseases were included in the study. Patients were randomized into 2 groups: in the main group (n=60), the information video edited by the researchers was shown to patients on the eve of discharge, in addition to a printed brochure on lifestyle and diet modification, and in the control group (n=60), patients were given only a standard brochure. The motivating video shows the damage to the cardiovascular system by the atherosclerotic process and the beneficial effect on the body of constant intake of statins. After 1 and 3 months after discharge from the hospital, telephone calls were made, after which the patients had to visit the center for an objective examination by a researcher and control of laboratory parameters. After 1 month, 110 patients visited the center, after 3 months, 98 respondents visited the center.Results. The group with the information video demonstration noted more frequent adherence to medical recommendations compared to the control: after 1 month, 52 (96%) patients continued treatment versus 48 (86%) patients, 3 months after discharge 48 (96%) patients continued treatment versus 38 (79%) patients (p<0.05). After 1 month, 38 (70%) patients in the intervention group continued taking statins versus 29 (43%) respondents in the control group (p<0.05), 3 months after discharge, 40 (80%) patients in the intervention group continued to take statins versus 33 (69%) control patients (p<0.09).Conclusion. Demonstration of a motivating video about the effect of statins on the atherosclerosis course increases patient adherence to medicinal therapy, including adherence to statins.

scholarly journals Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats

2007 ◽  
Vol 21 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Carlos Augusto Nassar ◽  
Patricia Oehlmeyer Nassar ◽  
Denise Carleto Andia ◽  
Morgana Rodrigues Guimarães ◽  
Maria Teresa Pepato ◽  
...  
Keyword(s):  
Serum Levels ◽  
Cardiovascular Complications ◽  
Term Therapy ◽  
Control Group ◽  
Post Transplantation ◽  
Tacrolimus Therapy ◽  
Biochemical Evaluation ◽  
Long Term Therapy

One of the more serious complications following transplantation is the development of post-transplantation diabetes mellitus (PTDM), which has a major impact on the quality of life, with effects ranging from the control of glycemia times to increased susceptibility to infections and cardiovascular complications. It has been suggested that immunosuppressive therapy, mainly tacrolimus therapy, may be an important factor in the development of PTDM. There is a lack of studies that explore the effects of long-term tacrolimus on PTDM in animal protocols. The objective of this study was therefore to evaluate the effects of long-term therapy with tacrolimus in rats. One group was treated with tacrolimus, injected subcutaneously, in a daily dose of 1 mg/kg of body weight. The chosen dose was sufficient to achieve therapeutic tacrolimus serum levels. The experimental periods were 60, 120, 180 and 240 days. One group was used as control and received daily subcutaneous injections of saline solution during all periods. A tendency towards increased glycemia levels during the initial periods (60 and 120 days) was observed. However, at 180 and 240 days, the glycemia levels were not statistically different from that of the control group of the same period. It may thus be concluded that the deleterious effects of tacrolimus therapy on glycemia may be a time-related side effect.

Immunoregulation of Autoimmune Disorders: The Role of Intravenous Immunoglobulins

1993 ◽  
Vol 16 (5_suppl) ◽  
pp. 189-195 ◽  
Author(s):  
G. Luzi ◽  
R. Ferrara
Keyword(s):  
Hematologic Malignancies ◽  
Intravenous Immunoglobulins ◽  
Term Therapy ◽  
Immune Modulators ◽  
Bacterial Diseases ◽  
Immunoglobulin Preparations ◽  
Original Observation ◽  
Long Term Therapy

Modified and intact immunoglobulin preparations are available for therapeutic use. The administration of intravenous immunoglobulins (IVI G) gave positive results in Primary Immunodeficiency Syndromes (PIS) (prophylaxis of viral and bacterial diseases), in treatment of secondary immunodeficiencies (hematologic malignancies, bone marrow transplantation), and in some infections. Adverse reactions have been reported during IVIG infusions, but they are rarely serious and do not represent limiting conditions for a short or long term therapy. After the original observation in thrombocytopenic purpura, IVIG have been used as immune modulators in various autoimmune related disorders. Various mechanisms of action are proposed: blockade and down regulation of phagocytic function via Fc receptor, regulation of idiotype-anti idiotype network, suppression of idiotype synthesis, T-B cell interference towards antigen presentation, increase in suppressor lymphocytes, IVIG-cytokine interaction.

THE RISK FACTORS FOR CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2020 ◽  
Vol 2 (1) ◽  
pp. 62-65
Author(s):  
M.R. Rahmetova ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Complications ◽  
Term Therapy ◽  
Patients With Diabetes ◽  
Long Term Therapy

Purpose: to study the influence of risk factors on the development of cardiovascular complications in patients with diabetes mellitus and to evaluate the effectiveness of treatment depending on the effect of certain factors. Materials and methods. Westudied 23 patients with type 2 diabetes mellitus with chronic cardiovascular complications, who were prescribed long-term therapy for diabetes and cardiovascular complications. Patients were offered questionnaires with questions about the prescribed treatment, the actual treatment received and the reasons for the violation of the recommendations.

scholarly journals Sustained hemodynamic improvement during long-term therapy with levodopa in heart failure: Role of plasma catecholamines

1987 ◽  
Vol 10 (6) ◽  
pp. 1286-1293 ◽  
Author(s):  
Sol I. Rajfer ◽  
James D. Rossen ◽  
John W. Nemanich ◽  
Frank L. Douglas ◽  
Fetima Davis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Plasma Catecholamines ◽  
Term Therapy ◽  
Hemodynamic Improvement ◽  
Long Term Therapy

scholarly journals Managing treatment fatigue in patients with multiple sclerosis on long-term therapy: the role of multiple sclerosis nurses

2014 ◽  
pp. 1093 ◽  
Author(s):  
Robert Ristuccia ◽  
Jewell Sally ◽  
Ann Crawford ◽  
Holly Mara ◽  
Laura McCatty ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Term Therapy ◽  
Long Term Therapy
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