Early Prenatal Diagnosis of Double Aortic Arch: Prevalence, Associated Anomalies and Outcome

2020 ◽  
Author(s):  
Osnat Zmora ◽  
Ron Beloosesky ◽  
Nizar Khatib ◽  
Yuval Ginsberg ◽  
Asad Khoury ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Aortic Arch ◽  
Early Pregnancy ◽  
Retrospective Cohort ◽  
First Trimester ◽  
Double Aortic Arch ◽  
Associated Anomalies ◽  
Genetic Abnormalities ◽  
Postnatal Outcome

Abstract Purpose Our aims were to describe the feasibility of diagnosis of DAA in early pregnancy and to assess its prenatal prevalence, associated anomalies and outcome. Materials and Methods A retrospective cohort review of all DAA cases diagnosed by early prenatal transvaginal scans at 12–17 weeks of gestation between the years 2007–2018 was performed. Associated anomalies, genetic abnormalities and long-term postnatal outcome were evaluated. Results 12 cases of DAA were diagnosed by early prenatal transvaginal scans at a median of 15 (range: 12–17) weeks of gestation out of a total of 28 654 early scans preformed with a prevalence of at least 1:2378. Associated anomalies/genetic abnormalities were found in 5/12 (42 %) cases. The diagnosis was confirmed postnatally in all newborns. In two cases termination of pregnancy was performed. Four patients (40 %) were symptomatic. Six patients (60 %) underwent surgery due to symptoms or due to severe obstruction on imaging with resolution of symptoms in all except one patient. Conclusion DAA can be readily diagnosed transvaginally even in the first trimester. Its prevalence is 1:2387. A search for associated anomalies and genetic abnormalities should be performed. If DAA is isolated, the prognosis with or without surgery is usually good.

scholarly journals Fetal double aortic arch: prenatal sonographic and postnatal computed tomography angiography features, associated abnormalities and clinical outcomes

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Qiao Guo ◽  
Yifan Kong ◽  
Shi Zeng ◽  
Jiawei Zhou ◽  
Xiaofang Wang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Prenatal Diagnosis ◽  
Aortic Arch ◽  
Clinical Outcomes ◽  
Computed Tomography Angiography ◽  
Double Aortic Arch ◽  
Chromosomal Anomalies ◽  
Branching Pattern ◽  
Associated Anomalies ◽  
Fetal Autopsy

Abstract Background Fetal double aortic arch (DAA) malformation is a rare congenital heart disease with few reported cases in the literature. We aimed to investigate the characteristics of prenatal ultrasound and postnatal computed tomography angiography (CTA) of DAA and to describe the associated anomalies and clinical outcomes to improve prenatal diagnosis and assist in perinatal management. Methods The obstetric ultrasound imaging databases of seven tertiary referral centers were reviewed retrospectively to identify fetuses with a prenatal diagnosis of DAA between January 2013 and December 2018. Ultrasonographic findings, associated anomalies, genetic abnormalities, postnatal CTA images, and long-term postnatal outcomes were evaluated. Results A total of 36 cases out of 40 prenatally diagnosed DAA fetuses were confirmed by postnatal diagnosis (fetal autopsy, CTA, and surgery). In this cohort of 36 confirmed cases, 24 (67%) were isolated anomalies, while 12 (33%) were associated with intracardiac or extracardiac anomalies, and 2 (6%) had a 22q11.2 chromosome deletion. Among nine cases of pregnancy termination with a fetal autopsy, 7 had other abnormalities. Among the remaining 27 live births, 16 (59%) were asymptomatic and 11 (41%) received surgical treatment due to tracheal or esophageal compression symptoms, all with satisfactory outcomes. Prenatal echocardiography showed that DAA was mainly characterized by a bifurcation of the ascending aorta into the right and left aortic arch and the formation of a complete O-shaped vascular ring around the trachea on the three-vessel tracheal view. A variant in the aortic arch branching pattern was found for the first time. The airway obstruction, branching pattern, and atretic arch of DAA were clearly shown by postnatal CTA. Conclusions Fetal DAA has unique features on prenatal echocardiography and postnatal CTA, and systematic prenatal examination and timely postnatal CTA evaluation are required. A certain proportion of intracardiac and extracardiac abnormalities are associated with DAA, but the probability of chromosome abnormalities is low, especially for isolated DAA.The clinical outcomes of isolated DAA are favorable, even if surgery is performed due to symptoms. Determining whether other malformations or chromosomal anomalies exist is crucial for prognosis evaluation and prenatal counseling.

scholarly journals Fetal double aortic arch: prenatal sonographic and postnatal computed tomography angiography features, associated abnormalities and clinical outcomes

2020 ◽  
Author(s):  
Qiao Guo ◽  
Yifan Kong ◽  
Shi Zeng ◽  
Jiawei Zhou ◽  
Xiaofang Wang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Prenatal Diagnosis ◽  
Aortic Arch ◽  
Clinical Outcomes ◽  
Computed Tomography Angiography ◽  
Double Aortic Arch ◽  
Chromosomal Anomalies ◽  
Branching Pattern ◽  
Associated Anomalies ◽  
Fetal Autopsy

Abstract Background: Fetal double aortic arch (DAA) malformation is a rare congenital heart disease with few reported cases in the literature. We aimed to investigate the characteristics of prenatal ultrasound and postnatal computed tomography angiography (CTA) of DAA and to describe the associated anomalies and clinical outcomes to improve prenatal diagnosis and assist in perinatal management. Methods: The obstetric ultrasound imaging databases of seven tertiary referral centers were reviewed retrospectively to identify fetuses with a prenatal diagnosis of DAA between January 2013 and December 2018. Ultrasonographic findings, associated anomalies, genetic abnormalities, postnatal CTA images, and long-term postnatal outcomes were evaluated. Results: A total of 36 cases out of 40 prenatally diagnosed DAA fetuses were confirmed by postnatal diagnosis (fetal autopsy, CTA, and surgery). In this cohort of 36 confirmed cases, 24 (67%) were isolated anomalies, while 12 (33%) were associated with intracardiac or extracardiac anomalies, and 2 (6%) had a 22q11.2 chromosome deletion. Among nine cases of pregnancy termination with a fetal autopsy, 7 had other abnormalities. Among the remaining 27 live births, 16 (59%) were asymptomatic and 11 (41%) received surgical treatment due to tracheal or esophageal compression symptoms, all with satisfactory outcomes. Prenatal echocardiography showed that DAA was mainly characterized by a bifurcation of the ascending aorta into the right and left aortic arch and the formation of a complete O-shaped vascular ring around the trachea on the three-vessel tracheal view. A variant in the aortic arch branching pattern was found for the first time. The airway obstruction, branching pattern, and atretic arch of DAA were clearly shown by postnatal CTA. Conclusions: Fetal DAA has unique features on prenatal echocardiography and postnatal CTA, and systematic prenatal examination and timely postnatal CTA evaluation are required. A certain proportion of intracardiac and extracardiac abnormalities are associated with DAA, but the probability of chromosome abnormalities is low, especially for isolated DAA.The clinical outcomes of isolated DAA are favorable, even if surgery is performed due to symptoms. Determining whether other malformations or chromosomal anomalies exist is crucial for prognosis evaluation and prenatal counseling.

Prenatal Diagnosis of Double Aortic Arch

2021 ◽  
Author(s):  
Helen Bornaun ◽  
Sema Süzen Çaypınar ◽  
Zeynep Gedik Özköse ◽  
Nura Fitnat Topbaş ◽  
Mustafa Behram
Keyword(s):  
Prenatal Diagnosis ◽  
Aortic Arch ◽  
Double Aortic Arch

Prenatal diagnosis of clubfoot in low-risk population: associated anomalies and long-term outcome

2008 ◽  
Vol 28 (4) ◽  
pp. 343-346 ◽  
Author(s):  
M. J. Canto ◽  
S. Cano ◽  
J. Palau ◽  
F. Ojeda
Keyword(s):  
Prenatal Diagnosis ◽  
Low Risk ◽  
Associated Anomalies ◽  
Term Outcome ◽  
Risk Population ◽  
Long Term Outcome

scholarly journals Prenatal diagnosis of the rare association of common arterial trunk and double aortic arch

2016 ◽  
Vol 4 (7) ◽  
pp. 668-670 ◽  
Author(s):  
Andrea Rock ◽  
Osama Eltayeb ◽  
Joseph Camarda ◽  
Nina Gotteiner
Keyword(s):  
Prenatal Diagnosis ◽  
Aortic Arch ◽  
Double Aortic Arch ◽  
Rare Association ◽  
Common Arterial Trunk ◽  
Arterial Trunk

Long-Term Outcomes of Double Aortic Arch Division in Children: 36-Year Experience from a Single Institution

2016 ◽  
Vol 25 (8) ◽  
pp. e99
Author(s):  
Phillip Naimo ◽  
Tyson Fricke ◽  
Julia Donald ◽  
Elie Sawan ◽  
Yves D’Udekem ◽  
...  
Keyword(s):  
Aortic Arch ◽  
Double Aortic Arch ◽  
Long Term Outcomes ◽  
Single Institution

Histopathological Diagnosis of Partial and Complete Hydatidiform Mole in the First Trimester of Pregnancy

2003 ◽  
Vol 6 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Neil J. Sebire ◽  
Rosemary A. Fisher ◽  
Helene C. Rees
Keyword(s):  
Early Pregnancy ◽  
Hydatidiform Mole ◽  
First Trimester ◽  
Histopathological Diagnosis ◽  
Molar Pregnancy ◽  
Diagnostic Problem ◽  
Complete Hydatidiform Mole ◽  
Products Of Conception ◽  
Genetic Abnormalities ◽  
First Trimester Of Pregnancy

The diagnosis of molar pregnancy is a continuing diagnostic problem for many practicing histopathologists who are required to examine specimens of products of conception, particularly since changes in gynecological management in recent years have resulted in uterine evacuation at earlier gestations. The aim of this review is to provide practical, up-to-date, diagnostically useful information regarding the histological diagnosis of molar disease in early pregnancy. Pathophysiological issues relevant to molar pregnancies, such as genetic abnormalities, will be briefly summarized, but nonhistopathological aspects of molar disease will not be covered in detail in this review.

scholarly journals Isolated Double Aortic Arch (Daa) – Prenatal Detection with Postnatal Follow-Up, Case Report and Literature Review

2018 ◽  
Vol 8 (1) ◽  
pp. 64-70
Author(s):  
Julia Murlewska ◽  
Agnieszka Żalińska ◽  
Danuta Roik ◽  
Bożena Werner ◽  
Maria Respondek-Liberska
Keyword(s):  
Case Report ◽  
Prenatal Diagnosis ◽  
Literature Review ◽  
Aortic Arch ◽  
Clinical Symptoms ◽  
Double Aortic Arch ◽  
Computer Reconstruction ◽  
Prenatal Detection ◽  
Angio Ct

Abstract This case report presents a prenatal diagnosis with postnatal confirmation (by angio CT and computer reconstruction) of an isolated double aortic arch, with no blood disturbances and with no clinical symptoms after birth. Literature review was focusing on the possible symptoms in the future. Prenatal findings should be forwarded to neonatologist and pediatrician despite clinical silence.

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