A Case Report of Dendritic Fibromyxolipoma in the Back of Pediatric Patient

2020 ◽  
Vol 232 (06) ◽  
pp. 328-330
Author(s):  
Yanling Jin ◽  
Lizhi Zhang
Keyword(s):  
Differential Diagnosis ◽  
Pediatric Patient ◽  
Immunohistochemical Staining ◽  
Myxoid Liposarcoma ◽  
Stellate Cells ◽  
The Elderly ◽  
Myxoid Stroma ◽  
Spindle Cells ◽  
Pathologic Features ◽  
Medical University

Abstract Objective To investigate the pathologic features and differential diagnosis of a pediatric dendritic fibromyxolipoma (DFML). Methods We collected one case of dendritic fibromyxolipoma in the back of a pediatric patient (6 years old, female) diagnosed at the First Affiliated Hospital of Dalian Medical University. The case of DFML was studied by H&E and MaxVision immunohistochemical staining. The clinical and pathological features were analyzed with review of the literatures Results The tumor was round or ovoid in shape and appeared in the surface of back. Microscopically, the tumor was mainly consisted of stellate to spindle cells, rope-like collagen fibers and varying amount of mature lipocytes embedded in myxoid stroma. Immunohistochemical staining showed that spindle cells and stellate cells were positive for vimentin, CD34 and BCL-2. Conclusion DFML is a rare special variant of lipoma. It is benign, and it seems to be misdiagnosed as myxoid liposarcoma prior to the admission to our hospital. The pathological histomorphology and immunohistochemistry phenotypes are helpful to the diagnosis and differential diagnosis. Given that DFML mainly occurs in the elderly, this case is rare and worthy to be reported since it occurs in children.

Primary leiomyoma of the thyroid gland

2003 ◽  
Vol 117 (10) ◽  
pp. 832-834 ◽  
Author(s):  
Suna Erkiliç ◽  
Ahmet Erkiliç ◽  
Yildirim A. Bayazit
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Subtotal Thyroidectomy ◽  
Muscle Actin ◽  
Thyroid Lobe ◽  
Surgical Specimen ◽  
Spindle Cells ◽  
The Right

Primary thyroid leiomyomas are rare, and only four cases have been reported to date. This is a report of an additional case of primary thyroid leiomyoma in a 40-year-old male who was admitted with a painless swelling in the right thyroid lobe and underwent subtotal thyroidectomy. The surgical specimen showed a well-circumscribed, greyish-white solid nodule. Histologically, the tumour was composed of spindle cells with blunt-ended nuclei that were arranged with short intersecting bundles.Immunohistochemical staining revealed reactivity with smooth muscle actin, vimentin and desmin. Histopathologic and immunohistochemical assessments produced the diagnosis of thyroid leiomyoma.Although primary thyroid leiomyoma is rare, it should be considered in the differential diagnosis of a cold thyroid nodule.

scholarly journals Well-Differentiated Liposarcoma of the Hypopharynx Exhibiting Myxoid Liposarcoma-like Morphology with MDM2 and DDIT3 Co-Amplification

2021 ◽  
Author(s):  
Khaled A. Murshed ◽  
Hayan Abo Samra ◽  
Adham Ammar
Keyword(s):  
Spermatic Cord ◽  
Gene Rearrangement ◽  
Rare Event ◽  
Soft Tissue Sarcomas ◽  
Myxoid Liposarcoma ◽  
Posterior Wall ◽  
Myxoid Stroma ◽  
Spindle Cells ◽  
Well Differentiated

AbstractWell-differentiated liposarcoma (WDL) is one of the most common soft tissue sarcomas in adults. It has a predilection for middle-aged males and arises in deep-seated locations such as retroperitoneum, mediastinum, and spermatic cord. Its occurrence in young individuals at the hypopharyngeal region is an exceedingly rare event. Myxoid liposarcoma (ML)-like changes can seldom occur in some cases of WDL, which makes the diagnosis of WDL more challenging. Amplification of DDIT3 gene in a subset of cases of WDL has shown to be associated with such unique morphology. Herein, we present a case of a 36-year-old gentleman who presented with difficulty in breathing and swallowing for 3 months duration. CT scan of the neck revealed a lesion along the posterior wall of the hypopharynx measuring 3.5 cm. Histopathologic examination revealed a tumor composed of lobules of oval to spindle cells in a prominent myxoid stroma with delicate chicken-wire vasculature. In the vicinity, there were lobules composed of variably sized adipocytes separated by thick fibrous septa that contains atypical hyperchromatic spindle cells. By immunohistochemistry, the tumor cells in both components were immunoreactive for CDK4, but negative for MDM2. Fluorescence in-situ hybridization (FISH) confirmed the presence of MDM2 gene amplification. There was no evidence of FUS-DDIT3 gene rearrangement, however, DDIT3 gene was also amplified. The diagnosis of well-differentiated liposarcoma with prominent myxoid stroma was rendered. This is the first documentation of WDL with ML-like morphology harboring co-amplification of MDM2 and DDIT3 in the hypopharynx.

Differential Diagnosis Between Dementia and Depression in the Elderly

1984 ◽  
Vol 2 (1) ◽  
pp. 23-35 ◽  
Author(s):  
Daniel K. Winstead ◽  
David H. Mielke
Keyword(s):  
Differential Diagnosis ◽  
The Elderly

Epilepsy and Related Disorders

2018 ◽  
Author(s):  
Barbara Dworetzky ◽  
Jong Woo Lee
Keyword(s):  
Differential Diagnosis ◽  
Generic Drugs ◽  
Sudden Change ◽  
Epileptic Seizures ◽  
Quality Measures ◽  
The Elderly ◽  
Childhood And Adolescence ◽  
Nonepileptic Seizures ◽  
Infancy And Early Childhood ◽  
The Brain

Epilepsy is a chronic disorder of the brain characterized by recurrent unprovoked seizures. A seizure is a sudden change in behavior that is accompanied by electrical discharges in the brain. Many patients presenting with a first-ever seizure are surprised to find that it is a very common event. A reversible or avoidable seizure precipitant, such as alcohol, argues against underlying epilepsy and therefore against treatment with medication. This chapter discusses the epidemiology, etiology, and classification of epilepsy and provides detailed descriptions of neonatal syndromes, syndromes of infancy and early childhood, and syndromes of late childhood and adolescence. The pathophysiology, diagnosis, and differential diagnosis are described, as are syncope, migraine, and psychogenic nonepileptic seizures. Two case histories are provided, as are sections on treatment (polytherapy, brand-name versus generic drugs, surgery, stimulation therapy, dietary treatments), complications of epilepsy and related disorders, prognosis, and quality measures. Special topics discussed are women?s issues and the elderly. Figures illustrate a left midtemporal epileptic discharge, wave activity during drowsiness, cortical dysplasias, convulsive syncope, rhythmic theta activity, right hippocamal sclerosis, and right temporal hypometabolism. Tables describe international classifications of epileptic seizures and of epilepsies, epilepsy syndromes and related seizure disorders, differential diagnosis of seizure, differentiating epileptic versus nonepileptic seizures, antiepileptic drugs, status epilepticus protocol for treatment, when to consider referral to a specialist, and quality measures in epilepsy.  This review contains 7 figures, 10 tables, and 33 references. Key Words: Seizures, focal (partial)seizure, generalized seizures, Myoclonic seizures, Atonic seizures, Concurrent electromyographyTonic-clonic (grand mal) seizures

scholarly journals Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast

2018 ◽  
Vol 6 ◽  
pp. 205031211881154 ◽  
Author(s):  
Ichiro Maeda ◽  
Shinya Tajima ◽  
Yoshihide Kanemaki ◽  
Koichiro Tsugawa ◽  
Masayuki Takagi
Keyword(s):  
Differential Diagnosis ◽  
Papillary Carcinoma ◽  
Carcinoma In Situ ◽  
Immunohistochemical Staining ◽  
Immunohistochemical Analysis ◽  
Intraductal Papilloma ◽  
Solid Papillary Carcinoma ◽  
Usual Ductal Hyperplasia ◽  
Ductal Hyperplasia

Objectives: The aim of this study was to use immunohistochemistry to differentiate solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia (IPUDH). Three types of high-molecular-weight cytokeratins (CKs) – CK5/6, CK14, and CK34betaE12 – were targeted. Methods: We studied 17 patients with solid papillary carcinoma in situ and 18 patients with IPUDH diagnosed by at least two pathologists. Immunohistochemical analyses used antibodies to CK5/6, CK14, and CK34betaE12 to make the differential diagnosis of solid papillary carcinoma in situ versus IPUDH. Immunohistochemical staining was scored as 0–5 using Allred score. Results: Immunohistochemistry with CK5/6 and CK14 antibodies produced scores of 0–3 in all patients with solid papillary carcinoma in situ and 2–5 in all patients with IPUDH. Immunohistochemical staining with CK34betaE12 antibody produced scores of 1–3 in all patients with solid papillary carcinoma and 3–5 in all patients with IPUDH. In tissues from patients with IPUDH, significantly more cells were stained with CK34betaE12 than CK5/6 ( p < 0.05) or CK14 ( p < 0.05). Conclusion: The immunoreactivity of CK5/6, CK14, and CK34betaE12 antibodies was useful to differentiate solid papillary carcinoma in situ from IPUDH. CK34betaE12 is especially useful for distinguishing solid papillary carcinoma from IPUDH.

scholarly journals Neuroschistosomiasis mimicking lower back pain: case report of a rare differential diagnosis in a pediatric patient

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Abdulrahman Hamad Al-Abdulwahhab ◽  
Abdulaziz Mohammad Al-Sharydah ◽  
Sari Saleh Al-Suhibani ◽  
Saeed Ahmad Al-Jubran ◽  
Ali Khalaf Al-Haidey ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Back Pain ◽  
Case Report ◽  
Pediatric Patient ◽  
Lower Back Pain ◽  
Lower Back ◽  
Rare Differential Diagnosis

Chronic Myelogenous Leukemia Presenting as a Secondary Malignancy After BCR-ABL1-negative B-lymphoblastic Leukemia/Lymphoma in a Pediatric Patient

2017 ◽  
Vol 20 (1) ◽  
pp. 58-62
Author(s):  
Gheorghe Popa ◽  
Cristina Blag ◽  
Horatiu Olteanu
Keyword(s):  
Complete Remission ◽  
Pediatric Patient ◽  
Chronic Myelogenous Leukemia ◽  
Pediatric Population ◽  
Lymphoblastic Leukemia ◽  
Myeloproliferative Neoplasm ◽  
Myelogenous Leukemia ◽  
Secondary Malignancy ◽  
Pediatric Malignancy ◽  
Pathologic Features

Chronic myelogenous leukemia, BCR-ABL1 positive (CML) is a rare myeloproliferative neoplasm in children and presents even less often as a secondary malignancy in the pediatric population. Below, we report a patient with Philadelphia-negative B-lymphoblastic leukemia/lymphoma, who developed CML several years after achieving complete remission, and summarize the existing literature on the clinical and pathologic features of CML as a secondary pediatric malignancy.

scholarly journals APPLICATION PROCEDURE EARL Y DIFERENTIAL DIAGNOSIS OF DIFERENT FORMS OF ODONTO - GENIC SEPSIS IN THE KURSK REGIONAL CLINICAL HOSPITAL WITH INTEGRATED SCALES APACHE-2 SOFA SAPS-2 SIRS

2014 ◽  
Vol 10 (6) ◽  
pp. 28-30
Author(s):  
А. Будаев ◽  
A. Budaev ◽  
А. Громов ◽  
A. Gromov ◽  
А. Зыкин ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Predictive Capability ◽  
Integral Scales ◽  
Medical Academy ◽  
Application Procedure ◽  
State Medical Academy ◽  
Medical University

<p>This work was devoted to improve the efficiency of diagnosis and treatment of patients with odontogenic phlegmons by studying predictive capability of different integral scales. The results of the use of methods for early differential diagnosis of various forms of odontogenic sepsis (development departments Kursk State Medical University and the Voronezh State Medical Academy. NNBurdenko): more than 30 points (the presence of multiple organ failure) – 22 patients (73,3%); less than 30 points (no organ failure) – 8 patients (26,7%). </p>

scholarly journals Meningitis, Clinical Presentation of Tetanus

2015 ◽  
Vol 2015 ◽  
pp. 1-2 ◽  
Author(s):  
Anna Moniuszko ◽  
Agata Zajkowska ◽  
Ewa Tumiel ◽  
Krzysztof Rutkowski ◽  
Piotr Czupryna ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Differential Diagnosis ◽  
Clinical Presentation ◽  
The Elderly ◽  
Developed Countries ◽  
Fatal Disease ◽  
Clostridium Tetani ◽  
Foot Injury ◽  
Sporadic Cases ◽  
Tetanus Immunization

Background. Tetanus is an acute disease caused by a neurotoxin produced byClostridium tetani. Tetanus immunization has been available since the late 1930s but sporadic cases still occur, usually in incompletely vaccinated or unvaccinated individuals.Case Report. An elderly previously vaccinated female contracted tetanus following foot injury. Clinically she presented with meningitis causing diagnostic and therapeutic delays.Why Should Physician Be Aware of This?Even in developed countries the differential diagnosis of meningitis, especially in the elderly, should include tetanus. Treatment in intensive care unit is required. General population might benefit from vaccine boosters and education on this potentially fatal disease.

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