Methylation Alkynylation of Terminal Alkenes via 1,2-Alkynyl Migration using Peroxides as the Methyl Resource
Keyword(s):
The metal-free oxidative alkene methylation/alkynylation of 1,4-enyn-3-ols with an organic peroxide as the methyl resource has been developed, which provides straightforward and practical access to the challenging quaternary carbon-containing but-3-yn-1-ones. The method is reasoned to go through methylation of functional alkenes utilizing DCP as the methyling reagents and subsequent intermolecular cyclization/1,2-alkynyl migration. This reaction has an excellent functional group tolerance, broad substrate scope and exquisite selectivity.