HMPA-Free Generation of Trialkylsilyllithium Reagents and Its Applications to the Synthesis of Silylboronic Esters

Synthesis ◽  
2021 ◽  
Author(s):  
Shintaro Kamio ◽  
Taiki Imagawa ◽  
Masaaki Nakamoto ◽  
Martin Oestreich ◽  
Hiroto Yoshida
Keyword(s):  
Phosphoric Triamide ◽  
Free Generation

Trialkylsilyllithium species have turned out to be facilely generated by treating hexaalkyldisilanes with methyllithium in the presence of tris(N,N-tetramethylene)phosphoric triamide (TPPA) as an activator, which can be trapped by boron electrophiles to afford silylboronic esters including long-awaited Me3Si–B(pin).

scholarly journals HMPA-Free Generation of Trialkylsilyl Lithium Reagents and Its Application to Synthesis of Silylboronic Esters

2021 ◽  
Author(s):  
Shintaro Kamio ◽  
Taiki Imagawa ◽  
Masaaki Nakamoto ◽  
Martin Oestreich ◽  
Hiroto Yoshida
Keyword(s):  
Phosphoric Triamide ◽  
Free Generation

Trialkylsilyl lithium species have turned out to be facilely generated by treating hexaalkyl disilanes with methyl lithium in the presence of tris(<i>N,N</i>-tetramethylene)phosphoric triamide (TPPA) as an activator, which can be trapped by boron electrophiles to afford silylboronic esters including long-awaited Me<sub>3</sub>Si–B(pin).

scholarly journals HMPA-Free Generation of Trialkylsilyl Lithium Reagents and Its Application to Synthesis of Silylboronic Esters

2021 ◽  
Author(s):  
Shintaro Kamio ◽  
Taiki Imagawa ◽  
Masaaki Nakamoto ◽  
Martin Oestreich ◽  
Hiroto Yoshida
Keyword(s):  
Phosphoric Triamide ◽  
Free Generation

Trialkylsilyl lithium species have turned out to be facilely generated by treating hexaalkyl disilanes with methyl lithium in the presence of tris(<i>N,N</i>-tetramethylene)phosphoric triamide (TPPA) as an activator, which can be trapped by boron electrophiles to afford silylboronic esters including long-awaited Me<sub>3</sub>Si–B(pin).

Towards an AIDS-free generation by 2030: how are South African children, adolescents, caregivers and health care workers coping with HIV?

2021 ◽  
pp. 008124632199217
Author(s):  
Yogan Pillay
Keyword(s):  
Health Care ◽  
Children And Adolescents ◽  
South African ◽  
Health Care Workers ◽  
Policy Makers ◽  
Number Of Children ◽  
Key Stakeholders ◽  
Care Workers ◽  
Free Generation ◽  
Living With Hiv

We are committed to an AIDS free generation by 2030 – nine short years away. This article reflects on the global and South African data on new infections, total number of children and adolescents living with HIV as well as data on vertical transmission. The article includes the voices of key stakeholders in the quest to end HIV in children so that lessons from their experiences can be used by policy makers in strengthening services.

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