Vergleich der biologischen Strahlenwirkung des β--Emitters 186Re mit 662 keV Photonenstrahlung auf die humane B-Zelllinie BV-173

2021 ◽  
Vol 60 (06) ◽  
pp. 438-444
Author(s):  
Jennifer Staudt ◽  
Christian Happel ◽  
Wolfgang Tilman Kranert ◽  
Benjamin Bockisch ◽  
Frank Grünwald
Keyword(s):  
Dose Rate ◽  
Low Dose ◽  
Biological Effects ◽  
Survival Curve ◽  
Photon Radiation ◽  
High Dose ◽  
Survival Curves ◽  
Photon Irradiation ◽  
Low Dose Rate ◽  
Accumulated Dose

Abstract Aim Aim of the study was to determine the effects of the β--emitter 186Re and 662 keV photon radiation in order to compare the biological effects of low dose rate (186Re) to high dose rate irradiation. Methods Prae-B-lymphocytes were exposed to 662 keV photon radiation or incubated with a liquid solution of 186Re. Cell count and viability were compared over the observation period of seven days, survival curves constructed and analysed at time of lowest cell-viability. Results Biphasic cell survival curves resulted for both radiation types. Survival curves were obtained at 24 h for photon radiation and 72 h for 186Re. The biphasic survival curve after photon radiation exposure can be explained by radiation hypersensitivity at doses below 1 Gy resulting in a D0 of 3.3 Gy. Doses exceeding 1.0 Gy showed a D0 of 10 Gy. The biphasic survival curve in case of 186Re incubation represents repair of sub lethal damage in the first section of the curve (D0 11.1 Gy) – in this case, biological effects of the β--emitter are attenuated by repair. Beyond an accumulated dose of 1.6 Gy, 186Re showed a steeper slope with a D0 of 4 Gy, corresponding to 2.5 times higher biological effects compared to acute photon irradiation (10 Gy). Conclusion Low dose rate radiation resulted in low biological effects at low doses. There is a threshold of accumulated dose above which biological effects of 186Re-incubation exceed those of photon irradiation.

LOW-DOSE-RATE OR HIGH-DOSE-RATE BRACHYTHERAPY IN COMBINATION WITH EXTERNAL BEAM RADIOTHERAPY FOR INTERMEDIATE AND HIGH-RISK PROSTATE CANCER

2018 ◽  
Vol 64 (1) ◽  
pp. 79-83
Author(s):  
Vladimir Solodkiy ◽  
Andrey Pavlov ◽  
Aleksey Tsybulskiy ◽  
Anton Ivashin
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Dose Rate ◽  
Low Dose ◽  
External Beam Radiotherapy ◽  
Combined Treatment ◽  
High Dose ◽  
External Beam ◽  
Low Dose Rate ◽  
Risk Of Progression

Introduction. One of the main problems of modem on-courology is treatment for prostate cancer of intermediate and high risk of progression. Modern radiotherapy in this category of patients has an advantage over surgical methods of treatment. One way to improve the effectiveness of radiotherapy is to escalate the dose in the prostate gland. For this purpose a combination of brachytherapy and remote radiotherapy is used. This combination allows increasing the dose of radiation, thereby providing better local control, reducing complications from neighboring organs. Purpose of the study. To conduct a comparative analysis of efficacy and safety of radical treatment of patients with prostate cancer at medium and high risk of progression using a combination of high and low dose rate brachytherapy with external beam radiotherapy. Materials and methods. 107 patients with prostate cancer of the group of medium and high risk of progression combined treatment (brachytherapy with external beam radiotherapy) was conducted. 53 patients underwent combined treatment (HDR-brachytherapy and external beam radiotherapy). 54 patients underwent combined treatment (LDR-brachytherapy and external beam radiotherapy). The observation period was 5 years. Conclusion. In a comparative analysis in groups of combined radiotherapy with the use of high-dose and low-dose-rate brachytherapy, the same effectiveness of immediate and long-term results of treatment was demonstrated. A significant reduction in early and late toxic reactions in patients with high-power brachytherapy has been demonstrated.

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