The trend of urinary NT-proBNP in extremely low birth weight infants during the neonatal period

2021 ◽  
Author(s):  
Safdar S khan ◽  
Henrietta S Bada ◽  
Maritza Torres ◽  
Melvin Almodovar ◽  
Mina Hanna
Keyword(s):  
Comparative Analysis ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Study Design ◽  
Clinical Utility ◽  
Neonatal Period ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Period Data ◽  
Infant Study

Background: NT-proBNP is a biomarker of interest in many cardiopulmonary diseases in extremely low birth weight (ELBW) Infants. However, there is a gap in knowledge about the trend of ELBW infant’s urinary NT-proBNP during the neonatal period. Aim: To determine the trend of urinary NT-proBNP during the first four weeks of life of an ELBW infant Study Design: We analyzed prospectively enrolled, 87 ELBW infants. Urinary NT-proBNP to creatinine ratios were measured on days 1-7, day 14, and day 28 of life. In addition, we plotted each study point's means to determine the trend of urinary NT-proBNP over the entire neonatal period. Data were analyzed using the Friedman ANOVA for comparative analysis of study points. Results: Urinary NT-proBNP/creatinine ratios were significantly elevated on days 1-7 (mean 2452, + 1518) than day 14 (mean 747, +176), and day 28 (mean149, +54), p=0.001. Overall, urinary NT-proBNP levels were highest during the days 1-3 (mean 3232+1255) and lowest on day 28 (mean149, +54). Conclusions: Urinary NT-proBNP levels are higher during the first week in ELBW infants with a downward trend during the neonatal period, with the lowest values at four weeks postnatal age. More studies are required to determine the clinical utility of this trend during and beyond the neonatal period.

scholarly journals The survival rate of extremely low birth weight infants improved in Guangdong Province, China

2021 ◽  
Author(s):  
Fan Wu ◽  
Chun-Hong Jia ◽  
Zhou-Shan Feng ◽  
Xiao-Jun Lin ◽  
Qi-Liang Cui ◽  
...  
Keyword(s):  
Overall Survival ◽  
Birth Weight ◽  
Survival Rate ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Neonatal Period ◽  
Periventricular Leukomalacia ◽  
Extremely Low Birth Weight ◽  
Overall Survival Rate ◽  
Low Birth Weight Infants

Abstract Background With the increase in extremely low birth weight (ELBW) infants, their outcomes received special attention. However, in China, studies of the outcomes of ELBW infants are rare. Methods The hospitalized records of ELBW infants discharged from twenty-six neonatal intensive care units were reviewed and analyzed. Results A total of 2575 ELBW infants were enrolled and the overall survival rate was 55.11%. From 2008 to 2017, the number of ELBW infants increased rapidly from 91 to 466, and the survival rate improved steadily from 41.76–62.02%. The survival rate rose with increasing BW, the ascending level of regional economic development and specialist hospitals. The incidence of complications was neonatal respiratory distress syndrome (85.2%), bronchopulmonary dysplasia (63.7%), retinopathy of prematurity (39.3%), intraventricular hemorrhage (29.4%), necrotizing enterocolitis (12.0%), and periventricular leukomalacia (8.0%). Among the 1156 nonsurvivors, 90.0% of infants died during the neonatal period (≤ 28 days), and the other died after the neonatal period. A total of 768 ELBW infants died after medical care withdrawal, with economic factors and expected outcome being important causes. Conclusion The number of ELBW infants is increasing in China, and the overall survival rate is still low but is improving steadily.

scholarly journals The Survival Rate of Extremely Low Birth Weight Infants Improved in Guangdong Province, China

2022 ◽  
Author(s):  
Chun-Hong Jia ◽  
Zhou-Shan Feng ◽  
Xiao-Jun Lin ◽  
Qi-Liang Cui ◽  
Sha-Sha Han ◽  
...  
Keyword(s):  
Overall Survival ◽  
Birth Weight ◽  
Survival Rate ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Neonatal Period ◽  
Periventricular Leukomalacia ◽  
Extremely Low Birth Weight ◽  
Overall Survival Rate ◽  
Low Birth Weight Infants

Abstract Background With the increase in extremely low birth weight (ELBW) infants, their outcomes received special attention. However, in China, studies of the outcomes of ELBW infants are rare. Methods The hospitalized records of ELBW infants discharged from twenty-six neonatal intensive care units were reviewed and analyzed. Results A total of 2575 ELBW infants were enrolled and the overall survival rate was 55.11%. From 2008 to 2017, the number of ELBW infants increased rapidly from 91 to 466, and the survival rate improved steadily from 41.76–62.02%. The survival rate rose with increasing BW, the ascending level of regional economic development and specialist hospitals. The incidence of complications was neonatal respiratory distress syndrome (85.2%), bronchopulmonary dysplasia (63.7%), retinopathy of prematurity (39.3%), intraventricular hemorrhage (29.4%), necrotizing enterocolitis (12.0%), and periventricular leukomalacia (8.0%). Among the 1156 nonsurvivors, 90.0% of infants died during the neonatal period (≤ 28 days), and the other died after the neonatal period. A total of 768 ELBW infants died after medical care withdrawal, with economic factors and expected outcome being important causes. Conclusion The number of ELBW infants is increasing in China, and the overall survival rate is still low but is improving steadily.

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