Synthesis of 1,3,4-Oxadiazoles by Iodine-mediated Oxidative Cyclization of Methyl Ketones with 4-Phenylsemicarbazide
Keyword(s):
One Pot
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An efficient one-pot method to access 5-amino-2-benzoyl-1,3,4-oxadiazoles via I2/DMSO promoted oxidative cyclization of 4-phenylsemicarbazide with (het)aryl methyl ketones under mild conditions was developed. This reaction proceeds smoothly with a wide range of methyl ketones containing different functional groups to give the corresponding products in moderate yields under mild conditions.