scholarly journals PEG Mediated Eco-Friendly One Pot Sunthesis of Benzylamine Coumarin Derivatives Using Multicomponent Reactant

2014 ◽  
Vol 30 ◽  
pp. 177-184
Author(s):  
Denish J. Viradiya ◽  
Vipul C. Kotadiya ◽  
Mita D. Khunt ◽  
Bharat H. Baria ◽  
Umed C. Bhoya
Keyword(s):  
Functional Groups ◽  
Aromatic Aldehyde ◽  
Elemental Analysis ◽  
Room Temperature ◽  
Coumarin Derivatives ◽  
One Pot ◽  
H Nmr ◽  
Wide Range ◽  
Hydroxy Coumarin ◽  
Target Molecules

A green resourceful, eco-friendly and facile protocol was developed for the synthesis of benzylamine coumarin derivatives by the reaction of 4-hydroxy coumarin, secondary amine and aromatic aldehyde in the presence of PEG400 as a solvent as well as catalyst at room temperature. A wide range of functional groups were tolerated in the developed protocol. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis. The target molecules were obtained in good to excellent yield applying this method.

Synthesis, photoinduced amination and topological indices of novel porphyrin dyads

2020 ◽  
Vol 24 (08) ◽  
pp. 1054-1065
Author(s):  
Muhammad Yaseen ◽  
Muhammad A. Rashid ◽  
Muhammad A. Iqbal ◽  
Zahid Farooq ◽  
Muhammad Idrees ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Transition Metal ◽  
Elemental Analysis ◽  
Room Temperature ◽  
Topological Indices ◽  
Operational Cost ◽  
One Pot ◽  
H Nmr ◽  
Metal Catalyzed ◽  
The One

Transition-metal-catalyzed homo and hetero coupling is a rapidly growing area of research. This work refers to the nickel-catalyzed photoinduced amination study of [Formula: see text]-bromotetraarylporphyrin and its Ni(II), Zn(II) and Cu(II) complexes. The selective mono [Formula: see text]-bromination of 5,10,15,20-tetrakis(4[Formula: see text]-isopropylphenyl)porphyrin was achieved with [Formula: see text]-bromosuccinimide. Under similar conditions, [Formula: see text]-bromination of Ni(II), Zn(II) and Cu(II) complexes of 5,10,15,20-tetrakis(4[Formula: see text]-isopropylphenyl)porphyrin successfully afforded the corresponding 2-bromometalloporphyrins. The [Formula: see text]-bromoporphyrin/metalloporphyrins were coupled with three different amines through the creation of the C–N bond by using an economical and air-tolerant photoactive catalyst (NiBr[Formula: see text] · 3H2O) at room temperature under 365 nm radiations. Nickel-catalyzed amination yields are compared with the traditional Buchwald–Hartwig amination yields. Due to the low operational cost, photoinduced nickel-catalyzed C–N couplings were found to be more economical than the Buchwald–Hartwig amination procedure, although the latter afforded higher yields. The nickel-catalyzed photoamination reaction was also extended for the one-pot synthesis of pyridine-3,5-diamine bridged porphyrin dyad. The intramolecular cyclization of the pyridine-3,5-diamine-bridged porphyrin dyad afforded a novel quinolino-fused porphyrin dyad. Degree- and distance-based topological indices of the newly synthesized porphyrins were calculated and correlated with their molar refractivity. All newly synthesized porphyrins are characterized by UV-vis, FTIR, 1H NMR, elemental analysis and mass spectrometry.

scholarly journals An Efficient One Pot Synthesis of some New 1,4-Dihydropyridine Derivatives Using Multicomponent Reaction

2015 ◽  
Vol 57 ◽  
pp. 45-50
Author(s):  
Devang R. Prajapati ◽  
Hardik K. Senjani ◽  
Yogesh T. Naliapara
Keyword(s):  
Nmr Spectroscopy ◽  
Multicomponent Reaction ◽  
Elemental Analysis ◽  
One Pot ◽  
H Nmr ◽  
One Pot Synthesis ◽  
Target Molecules ◽  
Dihydropyridine Derivatives ◽  
C Nmr

Synthesize target molecules, multicomponent reaction of 4-(4-aminophenyl) morpholin-3-one with various pyrazole aldehydes and ethylacetoacetate or methylacetoacetate afforded various 1,4-dihydropyridines derivatives. The newly synthesized compounds were characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis.

scholarly journals Synthesis, Characterization and Study of the Biological activity of Some Aldimines Derivatives

2006 ◽  
Vol 3 (4) ◽  
pp. 257-261 ◽  
Author(s):  
Mohamed N. Ibrahim ◽  
Hazem K. Al - Deeb
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
Aromatic Aldehyde ◽  
Aromatic Amine ◽  
Elemental Analysis ◽  
Primary Aromatic Amine ◽  
H Nmr

A number of imines derivatives have been synthesized, they were obtained by condensation of aromatic aldehyde derivatives with primary aromatic amine derivatives. Their structures have been characterised by IR,1H NMR in addition to the elemental analysis. The biological activity of these imines (which are also known as Schiff bases) were examined against different type of microorganisms and they found to have considerable activity in comparison with the most commonly used antibiotics.

One-pot multicomponent synthesis of highly functionalized bio-active pyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives using ZrO2 nanoparticles as a reusable catalyst

2015 ◽  
Vol 17 (5) ◽  
pp. 2859-2866 ◽  
Author(s):  
Arijit Saha ◽  
Soumen Payra ◽  
Subhash Banerjee
Keyword(s):  
Room Temperature ◽  
Zro2 Nanoparticles ◽  
Reusable Catalyst ◽  
Coumarin Derivatives ◽  
Multicomponent Synthesis ◽  
One Pot

Herein, a facile one-pot multicomponent protocol for the synthesis of biologically important pyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been demonstrated using ZrO2 nanoparticles as reusable catalyst at room temperature.

scholarly journals Unsymmetrical Difunctionalization of Two Different C–H Bonds in One Pot Under Transition-Metal Catalysis

Synthesis ◽  
2018 ◽  
Vol 51 (01) ◽  
pp. 40-54 ◽  
Author(s):  
Masahito Murai ◽  
Kazuhiko Takai
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Aromatic Compounds ◽  
Transition Metal Catalysis ◽  
One Pot ◽  
Metal Catalysis ◽  
Selective Functionalization ◽  
Sequential Addition ◽  
Target Molecules ◽  
Directing Group

Recent advancements in unsymmetrical difunctionalization based on the substitution of two different C–H bonds in one-pot are described. Due to the difficulty of controlling reactivity and selectivity, multi-functionalization via substitution of several C–H bonds to install different functional groups has been limited until recently, in comparison with well-studied functionalization via sequential addition to unsaturated π-bonds. This difunctionalization protocol provides an efficient and rapid approach to a library of structurally complicated target molecules through the formation of multiple C–X bonds with high atom- and step-economy.1 Introduction2 ortho-Selective Functionalization of Two Different C–H Bonds Relative to the Directing Group2.1 Unsymmetrical Difunctionalization with the Introduction of Similar Functional Groups2.2 Unsymmetrical Difunctionalization with the Introduction of Different Functional Groups2.3 ortho-Selective Unsymmetrical Difunctionalization Promoted by Two Different Directing Groups Appearing During the Progress of the Reaction3 ortho/meta-Selective C–H Bond Difunctionalization Relative to the Directing Group4 Sequential Difunctionalization of Fused Aromatic Compounds and Heterocycles5 Summary and Outlook

Synthesis of bis-spiropiperidines using nano-CuFe2O4@chitosan as a robust and retrievable heterogeneous catalyst

2017 ◽  
Vol 41 (7) ◽  
pp. 416-419 ◽  
Author(s):  
Javad Safaei-Ghomi ◽  
Mohammad Rasool Lashkari ◽  
Hossein Shahbazi-Alavi
Keyword(s):  
Heterogeneous Catalyst ◽  
Aromatic Amine ◽  
Room Temperature ◽  
Barbituric Acid ◽  
Catalyst Loading ◽  
Reaction Conditions ◽  
One Pot ◽  
Wide Range ◽  
One Pot Condensation

An efficient pseudo six-component synthesis of bis-spiropiperidines is described by one-pot condensation of formaldehyde, aromatic amine and dimedone or N,N-dimethyl-barbituric acid using nano-CuFe2O4@chitosan at room temperature. This method provides several advantages including mild reaction conditions, applicability to wide range of substrates, reusability of the catalyst and little catalyst loading.

Mild and Direct C–H Arylation of Quinoxalin-2(1H)-ones with Aryldiazonium Salts under Metal-Free Conditions

Synlett ◽  
2017 ◽  
Vol 29 (05) ◽  
pp. 597-602 ◽  
Author(s):  
Ronghua Zhang ◽  
Kun Yin
Keyword(s):  
Functional Groups ◽  
Room Temperature ◽  
Environmental Friendliness ◽  
Metal Free ◽  
Wide Range

A mild and direct C–H arylation of quinoxazolin-2(1H)-ones with aryldiazonium salts has been developed. A wide variety of 3-arylquinoxazolin-2(1H)-ones were synthesized in up to 92% yield at room temperature under metal-free conditions. This strategy tolerates a wide range of functional groups and shows environmental friendliness and practicality.

Base-Promoted Tandem Cyclization for the Synthesis of Polyfunctional 2-Hydroxy-2,3-dihydrofurans from Arylglyoxal Monohydrates and 3-(1H-Indol-3-yl)-3-oxopropanenitrile

Synlett ◽  
2018 ◽  
Vol 29 (14) ◽  
pp. 1926-1932
Author(s):  
Yi Liu ◽  
An-Xin Wu ◽  
Qun Cai ◽  
Hui-Yang Sheng ◽  
Deng-Kui Li
Keyword(s):  
Functional Groups ◽  
Michael Addition ◽  
Knoevenagel Condensation ◽  
One Pot ◽  
Wide Range ◽  
Reaction Proceeds ◽  
Tandem Cyclization ◽  
Arylglyoxal Monohydrates

An efficient base-promoted tandem cyclization for the synthesis of polyfunctional 2-hydroxy-2,3-dihydrofurans from arylglyoxal monohydrates and 3-(1H-indol-3-yl)-3-oxopropanenitrile has been established. The investigation of the mechanism suggested that this reaction proceeds through a Knoevenagel condensation–Michael addition–oxidation–cyclization sequence. This method demonstrates the compatibility with a wide range of functional groups to produce the 2-hydroxy-2,3-dihydrofuran scaffolds in good to excellent yields in one pot.

scholarly journals Zinc Triflate Promoted General Synthetic Protocol for the Facile Construction of Chromenes and Pyrimidines Bearing N-Allyl Quinolone Nucleus

2015 ◽  
Vol 47 ◽  
pp. 199-207
Author(s):  
Nileshkumar D. Vala ◽  
Hardik H. Jardosh ◽  
Manish P. Patel
Keyword(s):  
Elemental Analysis ◽  
13C Nmr ◽  
Room Temperature ◽  
Mass Spectral Data ◽  
One Pot ◽  
Mass Spectral ◽  
Cyclocondensation Reaction ◽  
Ft Ir ◽  
Derivatives Of ◽  
Zinc Triflate

A series of 8 derivatives of chromene 5a-h synthesized via one-pot cyclocondensation reaction of N-allyl quinolones, α/β naphthol and malononitrile. And 8 derivatives of pyrimidines 8a-h bearing N-allyl quinolone have been synthesized by N-allyl quinolones, ethylacetoacetate, thiourea/urea in the presence of zinc triflate as less toxic catalyst. This methodology allowed the high conversion of product at room temperature. Titled derivatives were elucidated by FT-IR, 1H NMR, 13C NMR, elemental analysis, and mass spectral data.

scholarly journals Synthesis of Tert-Octylsalicylaldoxime and Its Application in Extraction of Cu(II)

2021 ◽  
Vol 9 ◽  
Author(s):  
Liqing Li ◽  
Luo Feng ◽  
Chunfa Liao ◽  
Fangxu Li ◽  
Liqin Yang
Keyword(s):  
Elemental Analysis ◽  
Extraction Ability ◽  
One Pot ◽  
H Nmr ◽  
Alkyl Groups ◽  
Ft Ir ◽  
Copper Nickel Alloy ◽  
The One ◽  
Yield And Purity ◽  
C Nmr

The alkyl salicylaldoxime has attracted more and more attention recently due to the complex branched alkyl groups. In this study, a novel alkyl salicylaldoxime, tert-octylsalicylaldoxime, was successfully synthesized by the one-pot method. The yield and purity by the elemental analysis were 96.17 and 94.13%, respectively. The structure was confirmed by elemental analysis, FT-IR, 1H NMR (Nuclear Magnetic Resonance), 13C NMR spectroscopy, and MS. Results showed that tert-octylsalicylaldoxime with a new structure exhibited excellent extraction ability and selectivity for Cu(II) and can be successfully used to recover Cu from copper-nickel alloy electroplating wastewater. Thus, this product has the potential to be used as a powerful copper extractant in the future.

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