Prevention of nephrolithiasis by an extract of Ammi visnaga L. in stone forming rats

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
P Vanachayangkul ◽  
S Khan ◽  
V Butterweck
Keyword(s):  
2019 ◽  
Vol 9 (3) ◽  
pp. 197-206
Author(s):  
Kanika Patel ◽  
Mahfoozur Rahman ◽  
Vikas Kumar ◽  
Amita Verma ◽  
Dinesh Kumar Patel

Background: Ammi visnaga commonly known as ‘honey plant, tooth pick fruit, bisnaga and khella’ is an important plant of Apiaceae family. It is an annual herb found in Europe, Asia, North Africa, Latin America and in India. Carrot, parsnip, celery, coriander, anise, caraway, cumin, parsley and dill are some other plants of the same family i.e., ‘Apiaceae’. Fruits of Ammi visnaga (A. visnaga) are medicinally used as a strong photosensitizer, diaphoretic, carminative and antispasmodic agents. Objective: A. visnaga has been used for the treatment of bronchial asthma, coronary insufficiency, angina pectoris, psoriasis, renal colic and ureteric stones. Visnagin (C13H10O4) is a ‘furanochromone derivative’ which is the main active constituent’s of A. visnaga. Visnagin is used for the treatment of low blood-pressure, angina pectoris and kidney stone. It also has neuroprotective and antiinflammatory activity. Moreover, visnagin also treat whooping cough, ureter and bile duct, gall bladder and renal colic, tumors and epileptic seizures. Methods: This review summarizes data’s regarding the biological importance, pharmacological uses and medicinal importance of A. visnaga and their important active constituent’s “visnagin”. Moreover, the detailed pharmacological aspects of visnagin were presented in this review. Further various analytical techniques used for the extraction and isolation of visnagin were also discussed. Studies related to the pharmacological profile of the plants and their active phytoconstituents are one of the leading areas of research. Conclusion: This review will be beneficial to the scientific society to understand the importance of A. visnaga plant and their active constituents ‘visnagin’for the development of alternative tools to treat disorders in the future.


Author(s):  
Mohammed Waleed Arafah ◽  
Bader Almutairi ◽  
Mohammed Al-Zharani ◽  
Abdullah A. Alkahtane ◽  
Fatimah O. Al-Otibi ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1290
Author(s):  
Noha Khalil ◽  
Mokhtar Bishr ◽  
Mohamed El-Degwy ◽  
Mohamed Abdelhady ◽  
Mohamed Amin ◽  
...  

Background: Khella (Ammi visnaga Lam.) fruits (Apiaceae) are rich in furanochromones, mainly khellin and visnagin, and are thus incorporated in several pharmaceutical products used mainly for treatment of renal stones. Methods: The objective of this study was to compare the yield of khellin and visnagin obtained using different conventional solvents and supercritical fluid extraction (SCFE) with carbon dioxide (containing 5% methanol as co-solvent). Water, acetone and ethanol (30% and 95%) were selected as conventional solvents. Results: Highest extract yield was obtained from 30% ethanol (15.44%), while SCFE gave the lowest yield (4.50%). However, the percentage of furanochromones were highest in SCFE (30.1%), and lowest in boiling water extract (5.95%). HPLC analysis of conventional solvent extracts showed other coumarins that did not appear in supercritical fluid extraction chromatogram due to non-selectivity of solvent extraction. Ammi visnaga extracts as well as standard khellin and visnagin were tested for their cytotoxic activity using sulforhodamine B assay on breast cancer (MCF-7) and hepatocellular carcinoma (Hep G2) cell lines. Results revealed a strong cytotoxic activity (IC50 < 20 µg/mL) for the SCFE and standard compounds (khellin and visnagin) (IC50 ranging between 12.54 ± 0.57 and 17.53 ± 1.03 µg/mL). However, ethanol and acetone extracts had moderate cytotoxic activity (IC50 20–90 µg/mL) and aqueous extract had a weak activity (IC50 > 90 µg/mL). Conclusions: Thus, supercritical fluid extraction is an efficient, relatively safe, and cheap technique that yielded a more selective purified extract with better cytotoxic activity.


1975 ◽  
Vol 19 (4) ◽  
pp. 830
Author(s):  
M. N. Egyed ◽  
A. Shlosberg ◽  
A. Eilat
Keyword(s):  

1957 ◽  
Vol 290 (6) ◽  
pp. 291-292 ◽  
Author(s):  
G. Illing
Keyword(s):  

2016 ◽  
Vol 05 (04) ◽  
pp. 170-178 ◽  
Author(s):  
Kumudini M. Meepagala ◽  
Alden S. Estep ◽  
James J. Becnel

1969 ◽  
Vol 4 (2) ◽  
pp. 533-536
Author(s):  
SHAKIRULLAH JAN ◽  
SUBHANULLAH JAN ◽  
MUHAMMAD JAN ◽  
MASUD UR REHMAN

BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. This studywas undertaken to find out the effects of extract from the fruits of medicinal plant Ammi visnaga andseeds of Myristica fragrans (both of which contain documented natural Calcium channel blockers) onvolume and acidity of Carbachol induced gastric section. Their effects were also compared to find outany difference in their effect.DESIGN: Quasi experimental.PLACE & DURATION OF STUDY: Pharmacology Department Saidu Medical College Swat.METHODS: Thirty rabbits of local breed, weighing 1-1.5kg were used. The animals were kept onfasting for 48 hours, after which the pylorus of each animal was ligated. Carbachol 600iig/kg wasinjected to group A Extracts of Ammi visnaga and Myristica fragrans 500 mg/kg body weight each andafter 15 minutes Carbachol 600jlg/kg body weight was administered to group B & C intraperitoneally.RESULTS: It was found that both the extracts reduced the volume, free and total acidity of gastricsecretion, which were statistically highly significant when compared with Carbachol ( PcO.OOl). Whenthe differences of means for both the extracts were compared, all these were found statistically nonsignificant indicating that the extracts have similar effects on all parameters included in study.CONCLUSION: The extracts can be used effectively and safely in the treatment of hyper acidityconditions and peptic ulcer after evaluation of their effects in human.KEY WORDS: Ammi visnaga & Myristica fragrans, gastric secretion.


2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Iman Khallaf ◽  
Khalid Mohamed ◽  
Gehad Remeih ◽  
Rania Husseinb ◽  
Osama Ali ◽  
...  

2015 ◽  
Vol 46 (4) ◽  
pp. 559-567 ◽  
Author(s):  
Jadwiga H. Supniewska ◽  
Barbara Dohnal

Chromatographic examination of tissue from suspension cultures of <i>A. visnaga</i> proved their ability to biosynthesis of furanochromone-visnagin and furanocoumarin-marmesin. The occurrence of these two compounds depends on the composition of medium which also influences culture growth and embryogenesis, after subculture for at least l year


Sign in / Sign up

Export Citation Format

Share Document