Visnagin: A New Perspective of Medicinal Importance, Physiological Functions, Phytochemistry, Pharmacology and Analytical Aspects of Active Phytoconstituents of Ammi visnaga

Background: Ammi visnaga commonly known as ‘honey plant, tooth pick fruit, bisnaga and khella’ is an important plant of Apiaceae family. It is an annual herb found in Europe, Asia, North Africa, Latin America and in India. Carrot, parsnip, celery, coriander, anise, caraway, cumin, parsley and dill are some other plants of the same family i.e., ‘Apiaceae’. Fruits of Ammi visnaga (A. visnaga) are medicinally used as a strong photosensitizer, diaphoretic, carminative and antispasmodic agents. Objective: A. visnaga has been used for the treatment of bronchial asthma, coronary insufficiency, angina pectoris, psoriasis, renal colic and ureteric stones. Visnagin (C13H10O4) is a ‘furanochromone derivative’ which is the main active constituent’s of A. visnaga. Visnagin is used for the treatment of low blood-pressure, angina pectoris and kidney stone. It also has neuroprotective and antiinflammatory activity. Moreover, visnagin also treat whooping cough, ureter and bile duct, gall bladder and renal colic, tumors and epileptic seizures. Methods: This review summarizes data’s regarding the biological importance, pharmacological uses and medicinal importance of A. visnaga and their important active constituent’s “visnagin”. Moreover, the detailed pharmacological aspects of visnagin were presented in this review. Further various analytical techniques used for the extraction and isolation of visnagin were also discussed. Studies related to the pharmacological profile of the plants and their active phytoconstituents are one of the leading areas of research. Conclusion: This review will be beneficial to the scientific society to understand the importance of A. visnaga plant and their active constituents ‘visnagin’for the development of alternative tools to treat disorders in the future.

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Ammi Visnaga L., a Potential Medicinal Plant: A Review

Molecules ◽

10.3390/molecules25020301 ◽

2020 ◽

Vol 25 (2) ◽

pp. 301 ◽

Cited By ~ 1

Author(s):

Noha Khalil ◽

Mokhtar Bishr ◽

Samar Desouky ◽

Osama Salama

Keyword(s):

Essential Oil ◽

Renal Colic ◽

Biological Activities ◽

Chemical Constituents ◽

Modern Medicine ◽

Pharmacological Activities ◽

Coronary Insufficiency ◽

Relaxant Effect ◽

Ammi Visnaga ◽

Long Time

Ammi visnaga L. (Visnaga daucoides Gaertn., Family Apiaceae), also known as Khella Baldi or toothpick weed, is an annual or biennial herb indigenous to the Mediterranean region of North Africa, Asia, and Europe. The plant is known to have been used in traditional medicine a long time ago. Nowadays, it is used in modern medicine to treat many aliments such as renal colic and coronary insufficiency, and is used as an antioxidant, antifungal, and antibacterial, with a larvicidal effect on mosquito larvae. Peer-reviewed studies show that these pharmacological activities are due its valuable chemical constituents that include mainly essential oil, polyphenolic compounds including flavonoids, as well as γ-pyrones, represented mainly by khellin and visnagin. Its essential oil is reported to have antiviral, antibacterial, and larvicidal effects, while its flavonoid content is responsible for its antioxidant activity. Its γ-pyrone content has a powerful effect on facilitating the passage of kidney stones and relieving renal colic, in addition to having a relaxant effect on smooth muscle including that of the coronary arteries. The current review represents the progress in research on A. visnaga in terms of either its chemistry or biological activities. This review represents scientific support material for the use of the plant by the pharmaceutical industry.

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Heart rate variability analysis for the identification of the preictal interval in patients with drug-resistant epilepsy

Scientific Reports ◽

10.1038/s41598-021-85350-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Adriana Leal ◽

Mauro F. Pinto ◽

Fábio Lopes ◽

Anna M. Bianchi ◽

Jorge Henriques ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Linear Time ◽

Epileptic Seizures ◽

Heart Rate Variability Analysis ◽

Drug Resistant ◽

Clustering Methods ◽

Temporal Lobe Seizures ◽

New Perspective ◽

Drug Resistant Epilepsy

AbstractElectrocardiogram (ECG) recordings, lasting hours before epileptic seizures, have been studied in the search for evidence of the existence of a preictal interval that follows a normal ECG trace and precedes the seizure’s clinical manifestation. The preictal interval has not yet been clinically parametrized. Furthermore, the duration of this interval varies for seizures both among patients and from the same patient. In this study, we performed a heart rate variability (HRV) analysis to investigate the discriminative power of the features of HRV in the identification of the preictal interval. HRV information extracted from the linear time and frequency domains as well as from nonlinear dynamics were analysed. We inspected data from 238 temporal lobe seizures recorded from 41 patients with drug-resistant epilepsy from the EPILEPSIAE database. Unsupervised methods were applied to the HRV feature dataset, thus leading to a new perspective in preictal interval characterization. Distinguishable preictal behaviour was exhibited by 41% of the seizures and 90% of the patients. Half of the preictal intervals were identified in the 40 min before seizure onset. The results demonstrate the potential of applying clustering methods to HRV features to deepen the current understanding of the preictal state.

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Refractory Angina—An Overview and Recent Trends

Indian Journal of Cardiovascular Disease in Women WINCARS ◽

10.1055/s-0038-1622966 ◽

2017 ◽

Vol 02 (04) ◽

pp. 094-098

Author(s):

Meenakshi Kadiyala ◽

Rameshwar Roopchandar ◽

Chandrshekaran Krishnaswamy

Keyword(s):

Angina Pectoris ◽

Coronary Bypass ◽

Refractory Angina ◽

Coronary Insufficiency ◽

Poor General Health ◽

Percutaneous Coronary ◽

Recent Trends ◽

Artery Disease ◽

Refractory Angina Pectoris ◽

Improvement In Survival

AbstractBecause of improvement in survival from coronary artery disease and increasing life expectancy of the population, chronicity and resistance to therapy have become growing problems confronting the cardiologist. Refractory angina pectoris is an entity based on clinical diagnosis, and it refers to recurrent and sustained chest pain more than 3 months duration caused by coronary insufficiency that is unamenable to conventional modalities of treatment, including drugs, percutaneous coronary interventions, or coronary bypass grafting. Individuals with this entity may have an impaired quality of life, with recurrent angina, poor general health and psychological distress impairing functional and productive sustenance. A multitude of therapeutic options exists for patients with refractory angina pectoris, and randomized trials have shown them to be reasonably effective in reducing symptoms, though further research is warranted.

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