scholarly journals One Pot, Four Component Synthesis of Phthalazine-1,4-diones Derivatives in [BMIM][OH] Medium

2019 ◽  
Vol 32 (1) ◽  
pp. 45-48
Author(s):  
D.P. Loka Maheshwari ◽  
B. Satyanarayana
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Diethyl Phthalate ◽  
High Yield ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot

[BMIM][OH] mediated, green and efficient synthesis of phthalazines (5) have been developed by condensing diethyl phthalate (1), ethyl cyanohydrazide (2), substituted benzaldehyde (3) and malononitrile (4) in the presence of Meldrum’s acid at 60-65 °C and at room temperature for 60-90 min. The importance of this method includes shorter reaction time and high yield.

Phosphomolybdic Acid (PMA)-catalyzed One-pot Synthesis of 2,3- Dihydroquinazolines

2019 ◽  
Vol 16 (8) ◽  
pp. 683-687
Author(s):  
Chuanhuan Chen ◽  
A. Xuejiao ◽  
Xia Li ◽  
Guoli Huang ◽  
Bo Liu
Keyword(s):  
Reaction Time ◽  
Present Method ◽  
Room Temperature ◽  
Phosphomolybdic Acid ◽  
New Method ◽  
High Yield ◽  
One Pot ◽  
Short Reaction Time ◽  
One Pot Synthesis

We have developed a new method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yields via phosphomolybdic acid (PMA)-catalyzed cyclocondensation of 2- aminobenzamides with aldehydes or ketones in N,N-dimethylformamide (DMF) at room temperature. The present method proves to be efficient in terms of short reaction time, high yield, simple workup and easy purification.

Electrogenerated base-promoted synthesis of 5-aryl-5,6-dihydro-2H-pyrano[2,3-d]pyrimidine-2,4,7-triones by multicomponent assembly of barbituric acid, aldehydes and Meldrum's acid at room temperature

RSC Advances ◽  
2014 ◽  
Vol 4 (98) ◽  
pp. 55313-55317 ◽  
Author(s):  
Hojat Veisi ◽  
Abbas Maleki ◽  
Zahra Omrani ◽  
Shahram Lotfi
Keyword(s):  
Room Temperature ◽  
Barbituric Acid ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot

An electrochemical strategy for the synthesis of pyrano[2,3-d]pyrimidine-2,4,7-triones via a one-pot, three component condensation is described.

scholarly journals ZnO as an Efficient and Inexpensive Catalyst for One Pot Synthesis of 2, 4, 5 -Triphenyl-1H- imidazole Derivatives at Room Temperature

2011 ◽  
Vol 8 (3) ◽  
pp. 1339-1345 ◽  
Author(s):  
Babasaheb P. Bandgar ◽  
Baliram S. Hote ◽  
Balaji L. Korbad ◽  
Sachin A. Patil
Keyword(s):  
Reaction Time ◽  
Aromatic Aldehyde ◽  
Room Temperature ◽  
Synthetic Methods ◽  
High Yield ◽  
One Pot ◽  
Short Reaction Time ◽  
Reaction Condition ◽  
One Pot Synthesis ◽  
Environmental Friendly

An improved and rapid one pot synthesis of 2,4,6-triphenyl-1H-imidazoles on condensation with benzil, aromatic aldehyde and NH4OAc has been carried out using ZnO as an efficient and inexpensive catalyst in high yield at room temperature. The short reaction time, good yields (60-93%), environmental friendly procedure, mild reaction condition and convenient operation are important advantage of these synthetic methods.

The Efficient Synthesis of 1,3-Diallyloxy-2-Propanol without Solvent

2011 ◽  
Vol 311-313 ◽  
pp. 2106-2109
Author(s):  
Xi Mei Liu ◽  
Yu Hu ◽  
Li Hua Feng
Keyword(s):  
Allyl Alcohol ◽  
Large Scale ◽  
Room Temperature ◽  
Low Cost ◽  
High Yield ◽  
Scale Production ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Large Scale Production

An efficient and practical protocol for the preparation of 1,3-diallyloxy-2-propanol has been developed by one-pot reaction between epichlorohydrin and allyl alcohol in the presence of KOH without solvent at room temperature. This preliminary approach provides an environmentally-friendly synthetic route to 1,3-diallyloxy-2-propanol with many advantages, i. e., low cost, high yield, easy purification, mild reaction conditions, and large scale production.

An Expeditious One-Pot Three-Component Synthesis of 4-Aryl-3,4-dihydrobenzo[g] quinoline-2,5,10(1H)-triones under Green Conditions

2020 ◽  
Vol 23 (23) ◽  
pp. 2626-2634
Author(s):  
Saiedeh Kamalifar ◽  
Hamzeh Kiyani
Keyword(s):  
Reaction Medium ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
First Time ◽  
Green Conditions

: An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline- 2,5,10(1H)-triones was developed for the first time. The process proceeded via the three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)- one-ring naphthoquinones have been synthesized with good to high yields in refluxing ethanol as a green reaction medium. This protocol is simple and effective as well as does not involve the assistance of the catalyst, additive, or hazardous solvents.

Aqueous, One-Pot, Three-Component Reaction for Efficient Synthesis of 2-[4-(Arylsulfonyl)piperazin-1-yl]-1,3-benzothiazole, ‑1H-benzimidazole, or -1,3-benzoxazole Derivatives

Synlett ◽  
2017 ◽  
Vol 28 (17) ◽  
pp. 2295-2298
Author(s):  
Kommula Dileep ◽  
M. Murty
Keyword(s):  
Room Temperature ◽  
Efficient Synthesis ◽  
One Pot ◽  
Three Component Reaction ◽  
Aqueous Conditions

A simple and efficient synthetic protocol has been developed involving a one-pot three-component reaction of a 2-chlorobenzazole, piperazine, and an arenesulfonyl chloride under aqueous conditions at room temperature in the absence of a catalyst, ligand, or base. By using this protocol, a variety of 2-[4-(arylsulfonyl)piperazin-1-yl]-1,3-benzothiazole, -1H-benzimidazole, and -1,3-benzoxazole derivatives were synthesized in excellent yields.

scholarly journals One pot synthesis of 3, 4-dihydropyrimidine-2(1H)-thiones using orange peel powder under ultrasonic irradiation

2020 ◽  
Vol 9 (1) ◽  
pp. 919-923
Keyword(s):  
Reaction Time ◽  
Ultrasonic Irradiation ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Orange Peel ◽  
Biologically Active ◽  
High Yield ◽  
Atom Economy ◽  
One Pot ◽  
The Past

Biginelli, an important multicomponent reaction provides an avenue for the synthesis of different biologically active heterocyclic compounds. During the past decade, one pot multicomponent reactions have attracted the attention of organic and medicinal chemists due to high atom economy, time and enery saving convergent nature. The present manuscript reports a simple one pot three component synthesis of 3, 4-dihydroprimidin-2(1H)-thiones from various diversely substituted aldehydes, ethyl acetoacetate and thiourea using a orange peel powder as a natural catalyst on ultrasonic irradiation in aqueous medium as the solvent. The advantages of this reaction are less reaction time, high yield, easy availability of the catalyst and green nature.

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