Cytotoxic effects of hydroalcoholic extracts of Cucurbita pepo and Solanum nigrum compared with hydroalcoholic extract of Taxus baccata and cisplatin on normal and cancer cell lines

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
M Shokrzadeh ◽  
M Azadbakht ◽  
N Ahangar ◽  
H Naderi ◽  
SS Saeedi Saravi
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cucurbita Pepo ◽  
Cancer Cell Lines ◽  
Solanum Nigrum ◽  
Taxus Baccata ◽  
Cytotoxic Effects ◽  
Hydroalcoholic Extract

scholarly journals Cytotoxicity of hydro-alcoholic extracts of Cucurbita pepo and Solanum nigrum on HepG2 and CT26 cancer cell lines

2010 ◽  
Vol 6 (23) ◽  
pp. 176 ◽  
Author(s):  
M Shokrzadeh ◽  
M Azadbakht ◽  
N Ahangar ◽  
A Hashemi ◽  
SaeediS.S Saravi
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cucurbita Pepo ◽  
Cancer Cell Lines ◽  
Solanum Nigrum

Cytotoxic effects of novel polyoxotungstates and a platinum compound on human cancer cell lines

2005 ◽  
Vol 16 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Hans U. V. Gerth ◽  
Annette Rompel ◽  
Bernt Krebs ◽  
Joachim Boos ◽  
Claudia Lanvers-Kaminsky
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Platinum Compound ◽  
Human Cancer Cell ◽  
Cytotoxic Effects ◽  
Human Cancer Cell Lines

scholarly journals Antimicrobial and Cytotoxic Effects of Mexican Medicinal Plants

2011 ◽  
Vol 6 (12) ◽  
pp. 1934578X1100601 ◽  
Author(s):  
Maria del Rosario Jacobo-Salcedo ◽  
Angel Josabad Alonso-Castro ◽  
Luis A. Salazar-Olivo ◽  
Candy Carranza-Alvarez ◽  
Luis Ángel González-Espíndola ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Cytotoxic Effects ◽  
Antimicrobial Effects ◽  
Human Cancer Cell Lines ◽  
Guazuma Ulmifolia

The antimicrobial effects of the Mexican medicinal plants Guazuma ulmifolia, Justicia spicigera, Opuntia joconostle, O. leucotricha, Parkinsonia aculeata, Phoradendron longifolium, P. serotinum, Psittacanthus calyculatus, Tecoma stans and Teucrium cubense were tested against several human multi-drug resistant pathogens, including three Gram (+) and five Gram (-) bacterial species and three fungal species using the disk-diffusion assay. The cytotoxicity of plant extracts on human cancer cell lines and human normal non-cancerous cells was also evaluated using the MTT assay. Phoradendron longifolium, Teucrium cubense, Opuntia joconostle, Tecoma stans and Guazuma ulmifolia showed potent antimicrobial effects against at least one multidrug-resistant microorganism (inhibition zone > 15 mm). Only Justicia spicigera and Phoradendron serotinum extracts exerted active cytotoxic effects on human breast cancer cells (IC50≤30 μg/mL). The results showed that Guazuma ulmifolia produced potent antimicrobial effects against Candida albicans and Acinetobacter lwoffii, whereas Justicia spicigera and Phoradendron serotinum exerted the highest toxic effects on MCF-7 and HeLa, respectively, which are human cancer cell lines. These three plant species may be important sources of antimicrobial and cytotoxic agents.

scholarly journals Structure-Dependent Cytotoxic Effects of Eremophilanolide Sesquiterpenes

2017 ◽  
Vol 12 (5) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
M. Teresa Agulló-Ortuño ◽  
Carmen E. Díaz ◽  
Azucena González-Coloma ◽  
Matías Reina
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antitumor Agents ◽  
Cancer Cell Lines ◽  
Cytotoxic Activities ◽  
Cytotoxic Action ◽  
Cytotoxic Effects ◽  
Ic50 Values ◽  
Comparative Structure ◽  
Dose Dependent

The aim of this research was to determine the cytotoxic action of sixteen structurally-related eremophilane-type sesquiterpenes, isolated from several species of Senecio, against a panel of cancer cell lines. The cytotoxic activities were evaluated by WST-1 test and the IC50 values calculated. The investigated compounds exerted dose-dependent cytotoxic actions against selected cancer cell lines and no-tumoral HS5 cell line. The comparative structure-activity relationships demonstrated the importance of C-1, C-6, and C-8 substituents in the molecule. Our results show that eremophilane-type sesquiterpenes may represent an important source of novel potential antitumor agents due to their pronounced cytotoxic actions towards malignant cells.

Sign in / Sign up

Export Citation Format

Share Document