Dose-Response Relationship Between Interval Training Frequency and Magnitude of Improvement in Lactate Threshold

Abstract Stabilization exercise (SE) is evident for the management of chronic non-specific low back pain (LBP). The optimal dose-response-relationship for the utmost treatment success is, thus, still unknown. The purpose is to systematically review the dose-response-relationship of stabilisation exercises on pain and disability in patients with chronic non-specific LBP. A systematic review with meta-regression was conducted (Pubmed, Web of Knowledge, Cochrane). Eligibility criteria were RCTs on patients with chronic non-specific LBP, written in English/German and adopting a longitudinal core-specific/stabilising/motor control exercise intervention with at least one outcome for pain intensity and/or disability. Meta-regressions (dependent variable = effect sizes (Cohens d) of the interventions (for pain and for disability), independent variable = training characteristics (duration, frequency, time per session)), and controlled for (low) study quality (PEDro) and (low) sample sizes (n) were conducted to reveal the optimal dose required for therapy success. From the 3,415 studies initially selected, 50 studies (n = 2,786 LBP patients) were included. N = 1,239 patients received SE. Training duration was 7.0 ± 3.3 weeks, training frequency was 3.1 ± 1.8 sessions per week with a mean training time of 44.6 ± 18.0 min per session. The meta-regressions’ mean effect size was d = 1.80 (pain) and d = 1.70 (disability). Total R2 was 0.445 and 0.17. Moderate quality evidence (R2 = 0.231) revealed that a training duration of 20 to 30 min elicited the largest effect (both in pain and disability, logarithmic association). Low quality evidence (R2 = 0.125) revealed that training 3 to 5 times per week led to the largest effect of SE in patients with chronic non-specific LBP (inverted U-shaped association). In patients with non-specific chronic LBP, stabilization exercise with a training frequency of 3 to 5 times per week (Grade C) and a training time of 20 to 30 min per session (Grade A) elicited the largest effect on pain and disability.

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A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

Acta Endocrinologica ◽

10.1530/acta.0.0410268 ◽

1962 ◽

Vol 41 (2) ◽

pp. 268-273 ◽

Cited By ~ 9

Author(s):

Ralph I. Dorfman

Keyword(s):

Dose Response ◽

Subcutaneous Injection ◽

Response Relationship ◽

Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

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Dose-response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues

Diabetes ◽

10.2337/diabetes.41.2.241 ◽

1992 ◽

Vol 41 (2) ◽

pp. 241-253 ◽

Cited By ~ 16

Author(s):

Y. J. Yang ◽

I. Hope ◽

M. Ader ◽

R. A. Poulin ◽

R. N. Bergman

Keyword(s):

Insulin Sensitivity ◽

Glucose Uptake ◽

Dose Response ◽

Response Relationship ◽

Dose Response Relationship ◽

Peripheral Tissues

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Faculty Opinions recommendation of Dose-response relationship between cooking fumes exposures and lung cancer among Chinese nonsmoking women.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13741.471237 ◽

2006 ◽

Author(s):

Paolo Vineis

Keyword(s):

Lung Cancer ◽

Dose Response ◽

Response Relationship ◽

Dose Response Relationship ◽

Cooking Fumes

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Faculty Opinions recommendation of Activation of mTORC1 signalling in rat skeletal muscle is independent of the EC-coupling sequence but dependent on tension per se in a dose-response relationship.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736043008.793568723 ◽

2019 ◽

Author(s):

Craig A Goodman

Keyword(s):

Skeletal Muscle ◽

Dose Response ◽

Response Relationship ◽

Rat Skeletal Muscle ◽

Dose Response Relationship ◽

Ec Coupling ◽

Per Se ◽

Coupling Sequence

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Mathematical Interpretation of the Pharmacodynamics of Homoeopathic Medicines

Homœopathic Links ◽

10.1055/s-0040-1717132 ◽

2021 ◽

Vol 34 (01) ◽

pp. 003-016

Author(s):

John Michel Warner

Keyword(s):

Immune System ◽

Immune Responses ◽

Dose Response ◽

Oral Route ◽

Response Relationship ◽

Dose Response Relationship ◽

Force Line ◽

Administration Routes ◽

Medicinal Substances ◽

Medicine Administration

AbstractAccording to Hahnemann, homoeopathic medicines must be great immune responses inducers. In crude states, these medicines pose severe threats to the immune system. So, the immune-system of an organism backfires against the molecules of the medicinal substances. The complex immune response mechanism activated by the medicinal molecules can handle any threats which are similar to the threats posed by the medicinal molecules. The intersectional operation of the two sets, medicine-induced immune responses and immune responses necessary to cure diseases, shows that any effective homoeopathic medicine, which is effective against any disease, can induce immune responses which are necessary to cure the specific disease. In this article, this mechanism has been exemplified by the action of Silicea in human body. Also, a neuroimmunological assessment of the route of medicine administration shows that the oral cavity and the nasal cavity are two administration-routes where the smallest doses (sometimes even few molecules) of a particular homoeopathic medicine induce the most effective and sufficient (in amount) purgatory immune responses. Administering the smallest unitary doses of Silicea in the oral route can make significant changes in the vital force line on the dose–response relationship graph. The dose–response relationship graph further implicates that the most effective dose of a medicine must be below the lethality threshold. If multiple doses of any medicine are administered at same intervals, the immune-system primarily engages with the medicinal molecules; but along the passage of time, the engagement line splits into two: one engages with the medicinal molecules and another engages with diseases. The immune system's engagement with the diseases increases along the passage of time, though the engagement with the medicinal molecules gradually falls with the administration of descending doses. Necessarily, I have shown through mathematical logic that the descending doses, though they seem to be funny, can effectively induce the most effective immune responses.

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