Mathematical Interpretation of the Pharmacodynamics of Homoeopathic Medicines

2021 ◽  
Vol 34 (01) ◽  
pp. 003-016
Author(s):  
John Michel Warner

AbstractAccording to Hahnemann, homoeopathic medicines must be great immune responses inducers. In crude states, these medicines pose severe threats to the immune system. So, the immune-system of an organism backfires against the molecules of the medicinal substances. The complex immune response mechanism activated by the medicinal molecules can handle any threats which are similar to the threats posed by the medicinal molecules. The intersectional operation of the two sets, medicine-induced immune responses and immune responses necessary to cure diseases, shows that any effective homoeopathic medicine, which is effective against any disease, can induce immune responses which are necessary to cure the specific disease. In this article, this mechanism has been exemplified by the action of Silicea in human body. Also, a neuroimmunological assessment of the route of medicine administration shows that the oral cavity and the nasal cavity are two administration-routes where the smallest doses (sometimes even few molecules) of a particular homoeopathic medicine induce the most effective and sufficient (in amount) purgatory immune responses. Administering the smallest unitary doses of Silicea in the oral route can make significant changes in the vital force line on the dose–response relationship graph. The dose–response relationship graph further implicates that the most effective dose of a medicine must be below the lethality threshold. If multiple doses of any medicine are administered at same intervals, the immune-system primarily engages with the medicinal molecules; but along the passage of time, the engagement line splits into two: one engages with the medicinal molecules and another engages with diseases. The immune system's engagement with the diseases increases along the passage of time, though the engagement with the medicinal molecules gradually falls with the administration of descending doses. Necessarily, I have shown through mathematical logic that the descending doses, though they seem to be funny, can effectively induce the most effective immune responses.

2004 ◽  
Vol 67 (9) ◽  
pp. 2008-2015 ◽  
Author(s):  
ARIE HAVELAAR ◽  
JOHAN GARSSEN ◽  
KATSUHISA TAKUMI ◽  
MARJAN KOEDAM ◽  
WILMA RITMEESTER ◽  
...  

To evaluate the effects of differences in host cellular immunity, we studied the dose-response relationship for infection with Salmonella enterica serovar Enteritidis (SE) in two different rat strains, skewed towards T helper 1 (Th1, Lewis rats) or T helper 2 (Th2, Brown Norway rats) immunoregulation. Rats were exposed orally to different doses of SE after overnight starvation and neutralization of gastric acid. Animals were observed for clinical signs of disease, fecal excretion and SE load in spleen and cecum, histopathology of the cecum, hematology, and cellular and humoral immune responses. Exponential dose-response models were used for binary or continuous outcomes to analyze the experimental data. Cytokine patterns, antibody isotypes, and contact hypersensitivity tests confirmed that Lewis rats are Th1 prone, whereas Brown Norway rats are Th2 prone. The probability of infection per single SE cell was approximately 100 times higher in Brown Norway rats than in Lewis rats. Cellular immune responses were more pronounced in Lewis rats but antibody responses were higher in Brown Norway rats. When infected, colonization levels and inflammation are highest in the intestinal tract of Th2 skewed rats, but systemic infection is more intense in Th1 skewed rats. Successful colonization by only one or two SE clones resulted in a marked increase of neutrophil counts by a factor of two to three in both rat strains.


2016 ◽  
Vol 180 ◽  
pp. 54-65 ◽  
Author(s):  
Adam Michael Szlezak ◽  
Siri Lauluten Szlezak ◽  
James Keane ◽  
Lotti Tajouri ◽  
Clare Minahan

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.


Author(s):  
Satoru Kodama ◽  
Chika Horikawa ◽  
Kazuya Fujihara ◽  
Mariko Hatta ◽  
Yasunaga Takeda ◽  
...  

Atmosphere ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 371
Author(s):  
Yan Zhang ◽  
Weihua Yang ◽  
Günther Schauberger ◽  
Jianzhuang Wang ◽  
Jing Geng ◽  
...  

Municipal wastewater treatment plants (WWTPs) inside cities have been the major complained sources of odor pollution in China, whereas there is little knowledge about the dose–response relationship to describe the resident complaints caused by odor exposure. This study explored a dose–response relationship between the modelled exposure and the annoyance surveyed by questionnaires. Firstly, the time series of odor concentrations were preliminarily simulated by a dispersion model. Secondly, the perception-related odor exposures were further calculated by combining with the peak to mean factors (constant value 4 (Germany) and 2.3 (Italy)), different time periods of “a whole year”, “summer”, and “nighttime of summer”, and two approaches of odor impact criterion (OIC) (“odor-hour” and “odor concentration”). Thirdly, binomial logistic regression models were used to compare kinds of perception-related odor exposures and odor annoyance by odds ratio, goodness of fit and predictive ability. All perception-related odor exposures were positively associated with odor annoyance. The best goodness of fit was found when using “nighttime of summer” in predicting odor-annoyance responses, which highlights the importance of the time of the day and the time of the year weighting. The best predictive performance for odor perception was determined when the OIC was 4 ou/m3 at the 99th percentile for the odor exposure over time periods of nighttime of summer. The study of dose–response relationship could be useful for the odor management and control of WWTP to maximize the satisfaction of air quality for the residents inside city.


Sign in / Sign up

Export Citation Format

Share Document