Development of an Atrioventricular (AV) conduction block in the rat- investigation tool for effects of heart failure

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
S Pecha ◽  
F Weinberger ◽  
Y Yildirim ◽  
B Sill ◽  
L Conradi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Conduction Block ◽  
Av Conduction ◽  
Av Conduction Block

Suppressive effect of acetylcholine on action potentials of canine paranodal fibers

1986 ◽  
Vol 251 (4) ◽  
pp. H710-H715
Author(s):  
W. W. Tse
Keyword(s):  
Membrane Potential ◽  
Action Potential ◽  
Action Potential Duration ◽  
Action Potentials ◽  
Conduction Block ◽  
Suppressive Effect ◽  
Resting Membrane Potential ◽  
Av Conduction ◽  
Av Conduction Block

The canine atrioventricular (AV) junction comprises three major tissues: paranodal fibers (PNF), AV node (AVN), and His bundle (HB). In the present study, dissection-exposed, in vitro canine AV junctional preparations were used. The object of the study was to determine whether the PNF or AVN was more sensitive to the suppressive effect of acetylcholine (ACh). In five experiments these tissues were stimulated antegradely and retrogradely, and their action potentials were recorded simultaneously under the influence of ACh (0.5 micrograms/ml). Results indicated the PNF were more sensitive to the suppressive effect of ACh than were the AVN. In another group of 13 experiments, the effects of ACh at 0.05-0.3 micrograms/ml on rate of rise of phase 0 of action potentials (Vmax), peak potential, resting membrane potential, and action potential duration of the PNF were determined. Results indicated that ACh exerted a strong suppressive effect on Vmax and amplitude of the action potentials and had little effect on the resting membrane potential and action potential duration of the PNF. In 10 of 13 preparations, ACh also suppressed the response of PNF, resulting in generation of one action potential to every two stimuli. In conclusion, these findings suggest that PNF could be the tissue responsible for vagal-induced AV conduction block.

Piceatannol facilitates conduction block and ventricular fibrillation induction in ischemia-reperfused rabbit hearts with pacing-induced heart failure

2014 ◽  
Vol 171 (2) ◽  
pp. 250-258 ◽  
Author(s):  
Chung-Chuan Chou ◽  
Po-Cheng Chang ◽  
Ming-Shien Wen ◽  
Hui-Ling Lee ◽  
Hung-Ta Wo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ventricular Fibrillation ◽  
Conduction Block

Cardiac metastases from soft-tissue sarcomas.

1986 ◽  
Vol 4 (11) ◽  
pp. 1662-1669 ◽  
Author(s):  
D E Hallahan ◽  
N J Vogelzang ◽  
K M Borow ◽  
D G Bostwick ◽  
M A Simon
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Soft Tissue ◽  
Cardiac Involvement ◽  
Conduction Block ◽  
Soft Tissue Sarcomas ◽  
Signs And Symptoms ◽  
Atrial Myxoma ◽  
Cardiac Symptoms ◽  
Cardiac Metastases

Cardiac metastases were present in 30 of 120 (25%) consecutive autopsies of patients with soft-tissue sarcoma (STS). Fifty percent of the patients had metastases to the myocardium, while 33% had pericardial metastases and 17% had both. Congestive heart failure was present in ten patients and was commonly caused by diffuse myocardial or restrictive pericardial metastases. Other signs and symptoms of cardiac involvement by STS included chest pain (three patients), arrhythmias (two), conduction block (two), simulation of an atrial myxoma (one), and sudden death (one). Echocardiography was used infrequently, but was diagnostic in 80% of cases in which it was used. We conclude that metastatic STS commonly involves the heart and produces cardiac symptoms.

scholarly journals A case of infra-nodal Wenckebach conduction block with alternating bundle branch block

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Pichmanil Khmao ◽  
Chun Hwang ◽  
Hui-Nam Pak
Keyword(s):  
Conduction Block ◽  
Conduction Delay ◽  
Av Node ◽  
Bundle Branch Block ◽  
Case Presentation ◽  
Short Cycle ◽  
Purkinje System ◽  
Av Conduction ◽  
Premature Beats ◽  
Decremental Conduction

Abstract Background Atrioventricular (AV) node normally has decremental conduction property and a longer refractory period than His-Purkinje system (HPS). This results in AV conduction delay or block at the level of AV node in response to short-coupled atrial premature beats. Prolonged refractoriness in HPS can produce unusual physiological patterns of AV conduction such as conduction delay or infra-nodal block in the distal elements of HPS. Case presentation We present a case in which atrial premature stimulation produces infra-nodal Wenckebach conduction block which initiates long-short cycle sequence within the bundle branches resulted in alternating bundle branch block and atypical pattern of Ashman phenomenon. Conclusions This case highlights the importance of recognizing the unusual physiological AV conduction patterns of HPS. The long-short cycle sequence in the bundle branches of distal HPS and linking phenomenon can result in alternating bundle branch block without the presence of HPS disease.

DELAYED AV CONDUCTION PREDICTS OUTCOME IN THE RESYNCHRONIZATION-DEFIBRILLATION FOR AMBULATORY HEART FAILURE TRIAL (RAFT)

2015 ◽  
Vol 31 (10) ◽  
pp. S90-S91
Author(s):  
D. Chew ◽  
D.V. Exner ◽  
E. Yetisir ◽  
E. Yee ◽  
D.H. Birnie ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Failure Trial ◽  
Av Conduction

scholarly journals Atrioventricular Conduction in Mesial Temporal Lobe Seizures

2021 ◽  
Vol 12 ◽  
Author(s):  
Max C. Pensel ◽  
Luca M. Basili ◽  
Arthur Jordan ◽  
Rainer Surges
Keyword(s):  
Temporal Lobe ◽  
Linear Regression Analysis ◽  
Conduction Block ◽  
Analysis Data ◽  
Mesial Temporal Lobe Epilepsy ◽  
Cardiac Complications ◽  
Av Conduction ◽  
Temporal Lobe Seizures ◽  
Mesial Temporal Lobe ◽  
Hippocampal Seizures

Purpose: Asymmetric cerebral representation of autonomic function could help to stratify cardiac complications in people with epilepsy, as some seizures are associated with potentially deleterious arrhythmias including bradycardia and atrioventricular (AV) conduction block. We investigated seizure-related changes in AV conduction and ascertained whether these alterations depend on the hemisphere in mesial temporal lobe epilepsy (mTLE).Methods: EEG and ECG data of people with pharmacoresistant mTLE undergoing pre-surgical video-EEG telemetry with seizures independently arising from both hippocampi, as determined by intracranial depths electrodes were reviewed. RR and PR intervals were measured using one-lead ECG. Statistics were done with paired student's t-tests and linear regression analysis. Data are given as mean ± SD.Results: Fifty-six seizures of 14 patients (5 men, age 34.7 ± 9.8 years) were included (2 seizures per hemisphere and patient). There were no differences of absolute PR intervals and HR before and during unilateral ictal activity between left- and right-sided hippocampal seizures. Peri-ictal modulation of AV conduction, however, appeared greater with left-sided seizures, as the slope of the PR/HR correlations was significantly steeper with seizures originating in the left hippocampus. PR lengthening >200 ms or full block did not occur in any seizure.Conclusions: Our data show that on average, PR intervals shortens with mesial temporal lobe seizures with more prominent effects in seizures with left-sided onset, supporting the notion of lateralized cerebral control of cardiac function. The clinical relevance of this subtle finding is unclear but may indicate a lateralized susceptibility to seizure-related AV node dysfunction in mTLE.

Sign in / Sign up

Export Citation Format

Share Document