Early reoccurrence of fetal ED-A+ Fibronectin and B+ Tenascin-C splicing variants after human cardiac transplantation: potential impact for targeted therapy of chronic rejection

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
M. Franz ◽  
A. Berndt ◽  
M. Matusiak-Brückner ◽  
K. Grün ◽  
H. Maschek ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Chronic Rejection ◽  
Cardiac Transplantation ◽  
Tenascin C ◽  
Splicing Variants ◽  
Potential Impact

De novo expression of fetal ED-A+ fibronectin and B+ tenascin-C splicing variants in human cardiac allografts: potential impact for targeted therapy of rejection

2014 ◽  
Vol 45 (5) ◽  
pp. 519-532 ◽  
Author(s):  
Marcus Franz ◽  
Monika Matusiak-Brückner ◽  
Petra Richter ◽  
Katja Grün ◽  
Barbara Ziffels ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
De Novo ◽  
Tenascin C ◽  
Splicing Variants ◽  
Cardiac Allografts ◽  
Potential Impact

scholarly journals Tenascin-C in cardiovascular remodeling: potential impact for diagnosis, prognosis estimation and targeted therapy

2015 ◽  
Vol 9 (1-2) ◽  
pp. 90-95 ◽  
Author(s):  
Marcus Franz ◽  
Christian Jung ◽  
Alexander Lauten ◽  
Hans R Figulla ◽  
Alexander Berndt
Keyword(s):  
Targeted Therapy ◽  
Cardiovascular Remodeling ◽  
Tenascin C ◽  
Potential Impact ◽  
Prognosis Estimation

scholarly journals RhoA- and Actin-Dependent Functions of Macrophages from the Rodent Cardiac Transplantation Model Perspective -Timing Is the Essence

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 70
Author(s):  
Malgorzata Kloc ◽  
Ahmed Uosef ◽  
Martha Villagran ◽  
Robert Zdanowski ◽  
Jacek Z. Kubiak ◽  
...  
Keyword(s):  
Immune Response ◽  
Circadian Rhythm ◽  
Immune Cells ◽  
Chronic Rejection ◽  
Cardiac Transplantation ◽  
Small Gtpase ◽  
Eukaryotic Cells ◽  
Transplantation Model

The small GTPase RhoA, and its down-stream effector ROCK kinase, and the interacting Rac1 and mTORC2 pathways, are the principal regulators of the actin cytoskeleton and actin-related functions in all eukaryotic cells, including the immune cells. As such, they also regulate the phenotypes and functions of macrophages in the immune response and beyond. Here, we review the results of our and other’s studies on the role of the actin and RhoA pathway in shaping the macrophage functions in general and macrophage immune response during the development of chronic (long term) rejection of allografts in the rodent cardiac transplantation model. We focus on the importance of timing of the macrophage functions in chronic rejection and how the circadian rhythm may affect the anti-chronic rejection therapies.

scholarly journals LATE BLOCKADE OF B7-1 COSTIMULATION INTERRUPTS THE DEVELOPMENT OF CHRONIC REJECTION IN A RAT MODEL OF CARDIAC TRANSPLANTATION

1998 ◽  
Vol 65 (12) ◽  
pp. S182
Author(s):  
M D. Denton ◽  
A. Knoflach ◽  
R. Milord ◽  
A. Chandraker ◽  
L. A. Turka ◽  
...  
Keyword(s):  
Rat Model ◽  
Chronic Rejection ◽  
Cardiac Transplantation

scholarly journals Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1

Oncotarget ◽  
2016 ◽  
Vol 7 (36) ◽  
pp. 57811-57820 ◽  
Author(s):  
Noureldien H.E. Darwish ◽  
Thangirala Sudha ◽  
Kavitha Godugu ◽  
Osama Elbaz ◽  
Hasan A. Abdelghaffar ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Targeted Therapy ◽  
Myeloid Leukemia ◽  
Stem Cell Markers ◽  
Leukemia Stem Cell ◽  
Cell Markers ◽  
Potential Impact ◽  
Acute Myeloid

scholarly journals Cold ischemia contributes to the development of chronic rejection and mitochondrial injury after cardiac transplantation

2010 ◽  
Vol 23 (12) ◽  
pp. 1282-1292 ◽  
Author(s):  
Stefan Schneeberger ◽  
Albert Amberger ◽  
Julia Mandl ◽  
Theresa Hautz ◽  
Oliver Renz ◽  
...  
Keyword(s):  
Chronic Rejection ◽  
Cardiac Transplantation ◽  
Cold Ischemia ◽  
Mitochondrial Injury

Chronic Rejection in Experimental Cardiac Transplantation: Studies in the Lewis-F344 Model

1993 ◽  
Vol 134 (1) ◽  
pp. 5-19 ◽  
Author(s):  
David H. Adams ◽  
Mary E. Russell ◽  
Wayne W. Hancock ◽  
Mohamed H. Sayegh ◽  
Lauri R. Wyner ◽  
...  
Keyword(s):  
Chronic Rejection ◽  
Cardiac Transplantation
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