Changes in extra cellular matrix remodelling and re-expression of fibronectin and tenascin-C splicing variants in human myocardial tissue of the right atrial auricle: implications for a targeted therapy of cardiovascular diseases using human SIP format antibodies

2010 ◽  
Vol 41 (1) ◽  
pp. 39-50 ◽  
Author(s):  
Marcus Franz ◽  
Bernhard R. Brehm ◽  
Petra Richter ◽  
Katja Gruen ◽  
Dario Neri ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cardiovascular Diseases ◽  
Extra Cellular Matrix ◽  
Right Atrial ◽  
Myocardial Tissue ◽  
Tenascin C ◽  
Splicing Variants ◽  
The Right ◽  
Cellular Matrix

scholarly journals A Brief History in Cardiac Regeneration, and How the Extra Cellular Matrix May Turn the Tide

2021 ◽  
Vol 8 ◽  
Author(s):  
Atze van der Pol ◽  
Carlijn V. C. Bouten
Keyword(s):  
Current Knowledge ◽  
Cardiac Regeneration ◽  
Stressful Events ◽  
Extra Cellular Matrix ◽  
Myocardial Tissue ◽  
Cell Source ◽  
Cell Sources ◽  
A Cell ◽  
Contractile Tissue ◽  
Cellular Matrix

Tissue homeostasis is perturbed by stressful events, which can lead to organ dysfunction and failure. This is particularly true for the heart, where injury resulting from myocardial infarction or ischemic heart disease can result in a cascading event ultimately ending with the loss of functional myocardial tissue and heart failure. To help reverse this loss of healthy contractile tissue, researchers have spent decades in the hopes of characterizing a cell source capable of regenerating the injured heart. Unfortunately, these strategies have proven to be ineffective. With the goal of truly understanding cardiac regeneration, researchers have focused on the innate regenerative abilities of zebrafish and neonatal mammals. This has led to the realization that although cells play an important role in the repair of the diseased myocardium, inducing cardiac regeneration may instead lie in the composition of the extra cellular milieu, specifically the extra cellular matrix. In this review we will briefly summarize the current knowledge regarding cell sources used for cardiac regenerative approaches, since these have been extensively reviewed elsewhere. More importantly, by revisiting innate cardiac regeneration observed in zebrafish and neonatal mammals, we will stress the importance the extra cellular matrix has on reactivating this potential in the adult myocardium. Finally, we will address how we can harness the ability of the extra cellular matrix to guide cardiac repair thereby setting the stage of next generation regenerative strategies.

De novo expression of fetal ED-A+ fibronectin and B+ tenascin-C splicing variants in human cardiac allografts: potential impact for targeted therapy of rejection

2014 ◽  
Vol 45 (5) ◽  
pp. 519-532 ◽  
Author(s):  
Marcus Franz ◽  
Monika Matusiak-Brückner ◽  
Petra Richter ◽  
Katja Grün ◽  
Barbara Ziffels ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
De Novo ◽  
Tenascin C ◽  
Splicing Variants ◽  
Cardiac Allografts ◽  
Potential Impact

Giant Right Atrial Diverticulum in a Foal

2002 ◽  
Vol 14 (4) ◽  
pp. 335-337 ◽  
Author(s):  
Janet C. Patterson-Kane ◽  
Lenn R. Harrison
Keyword(s):  
Heart Failure ◽  
Respiratory Distress ◽  
Septic Arthritis ◽  
Postmortem Examination ◽  
Right Atrial ◽  
Myocardial Tissue ◽  
Lateral Aspect ◽  
Giant Diverticulum ◽  
History Of ◽  
The Right

A 5-month-old male Thoroughbred foal with a history of chronic septic arthritis of the tibiotarsal joint and recent respiratory distress was euthanized and a postmortem examination performed. A giant diverticulum communicating with the lateral aspect of the right atrial cavity of the heart was observed. Histologically, the wall was comprised of myocardial tissue containing cavernous vascular spaces. There was gross and histologic evidence of right-sided heart failure. Congenital right atrial diverticula are rare anomalies in humans and have not previously been reported in foals.

scholarly journals Primary cardiac angiosarcoma: a case report

2021 ◽  
Vol 49 (8) ◽  
pp. 030006052110332
Author(s):  
Xin Fang ◽  
Song Zheng
Keyword(s):  
Targeted Therapy ◽  
Concurrent Chemoradiotherapy ◽  
Treatment Plan ◽  
Right Atrial ◽  
Rapid Progression ◽  
Correct Treatment ◽  
Cardiac Angiosarcoma ◽  
The Right ◽  
Radical Surgical Resection

Primary cardiac angiosarcoma is relatively rare, and most cases involve metastasis at the time of diagnosis. The median survival time is 14 months for patients who can be treated surgically, versus 3.8 ± 2.5 months for patients with metastasis who could not undergo surgery. Radical surgical resection, radiotherapy, chemotherapy, and targeted therapy are the main treatments, but prognosis remains poor because of rapid progression and high recurrence and metastasis rates. At present, there is no unified standard treatment, and selecting the correct treatment plan and improving patient survival and quality of life remain challenging. We have reported the case of a 45-year-old woman with a primary heart tumor that infiltrated the right atrial wall and pericardium. Angiosarcoma was verified histologically. After palliative resection of the primary tumor followed by concurrent chemoradiotherapy and targeted therapy, the patient exhibited overall survival of 23 months, highlighting the potential utility of this treatment strategy.

Extra cellular matrix remodelling in chronic cardiac allograft rejection

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
M Franz ◽  
A Berndt ◽  
K Grün ◽  
D Neri ◽  
H Kosmehl ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
Cardiac Allograft ◽  
Extra Cellular Matrix ◽  
Cardiac Allograft Rejection ◽  
Cellular Matrix

Closure of Secundum Atrial Septal Defect with Autologous Right Atrial Patch: Case Report

2005 ◽  
Vol 8 (2) ◽  
pp. 96 ◽  
Author(s):  
Osman Tansel Dar�in ◽  
Alper Sami Kunt ◽  
Mehmet Halit Andac
Keyword(s):  
Atrial Septal Defect ◽  
Right Atrium ◽  
Septal Defect ◽  
Complete Recovery ◽  
Interatrial Septum ◽  
Right Atrial ◽  
Atrial Wall ◽  
Residual Shunt ◽  
Asd Closure ◽  
The Right

Background: Although various synthetic materials and pericardium have been used for atrial septal defect (ASD) closure, investigators are continuing to search for an ideal material for this procedure. We report and evaluate a case in which autologous right atrial wall tissue was used for ASD closure. Case: In this case, we closed a secundum ASD of a 22-year-old woman who also had right atrial enlargement due to the defect. After establishing standard bicaval cannulation and total cardiopulmonary bypass, we opened the right atrium with an oblique incision in a superior position to a standard incision. After examining the secundum ASD, we created a flap on the inferior rim of the atrial wall. A stay suture was stitched between the tip of the flap and the superior rim of the defect, and suturing was continued in a clockwise direction thereafter. Considering the size and shape of the defect, we incised the inferior attachment of the flap, and suturing was completed. Remnants of the flap on the inferior rim were resected, and the right atrium was closed in a similar fashion. Results: During an echocardiographic examination, neither a residual shunt nor perigraft thrombosis was seen on the interatrial septum. The patient was discharged with complete recovery. Conclusion: Autologous right atrial patch is an ideal material for ASD closure, especially in patients having a large right atrium. A complete coaptation was achieved because of the muscular nature of the right atrial tissue and its thickness, which is a closer match to the atrial septum than other materials.

Altered Expression of Extra-Cellular Matrix Proteins and Integrin Receptors in Discoid Lupus Erythematosus

2004 ◽  
Vol 1 (4) ◽  
pp. 368-371
Author(s):  
Gianluigi Giannelli ◽  
Concetta Sgarra ◽  
Caterina Foti ◽  
Carlo Bergamini ◽  
Carmela Coviello ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Extra Cellular Matrix ◽  
Matrix Proteins ◽  
Discoid Lupus Erythematosus ◽  
Integrin Receptors ◽  
Altered Expression ◽  
Cellular Matrix

The Role of Cytokines in Interactions of Mesenchymal Stem Cells and Breast Cancer Cells

2020 ◽  
Vol 15 ◽  
Author(s):  
Hariharan Jayaraman ◽  
Nalinkanth V. Ghone ◽  
Ranjith Kumaran R ◽  
Himanshu Dashora
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Cell Communication ◽  
Extra Cellular Matrix ◽  
Cytokine Signaling ◽  
Cellular Matrix

: Mesenchymal stem cells because of its high proliferation, differentiation, regenerative capacity, and ease of availability have been a popular choice in cytotherapy. Mesenchymal Stem Cells (MSCs) have a natural tendency to home in a tumor microenvironment and acts against it, owing to the similarity of the latter to an injured tissue environment. Several studies have confirmed the recruitment of MSCs by tumor through various cytokine signaling that brings about phenotypic changes to cancer cells, thereby promoting migration, invasion, and adhesion of cancer cells. The contrasting results on MSCs as a tool for cancer cytotherapy may be due to the complex cell to cell interaction in the tumor microenvironment, which involves various cell types such as cancer cells, immune cells, endothelial cells, and cancer stem cells. Cell to cell communication can be simple or complex and it is transmitted through various cytokines among multiple cell phenotypes, mechano-elasticity of the extra-cellular matrix surrounding the cancer cells, and hypoxic environments. In this article, the role of the extra-cellular matrix proteins and soluble mediators that acts as communicators between mesenchymal stem cells and cancer cells has been reviewed specifically for breast cancer, as it is the leading member of cancer malignancies. The comprehensive information may be beneficial in finding a new combinatorial cytotherapeutic strategy using MSCs by exploiting the cross-talk between mesenchymal stem cells and cancer cells for treating breast cancer.

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