Background:
Gentiana lutea (GL), commonly known as yellow gentian, bitter root, and
bitterwort, belongs to family Gentianaceae. GL belongs to genus Gentiana, which is a rich
natural source of iridoids, secoiridoids, xantones, flavonoids, triterpenoids, and carbohydrates.
Medicinal plants from Gentiana species have anti-oxidant, anti-inflammatory, anti-mitogenic,
anti-proliferative, and lipid-lowering effects, as well as a cardioprotective, hypotensive,
vasodilator and anti-platelet activities.
Objective:
We reviewed the recent literature related to the effects of Gentiana species, and their
active components on vascular diseases.
Methods:
Data used for this review were obtained by searching the electronic database
[PUBMED/MEDLINE 1973 - February 2020]. The primary data search terms of interest were:
Gentiana lutea, Gentienacea family, phytochemistry, vascular diseases, treatment of vascular
diseases, anti-oxidant, anti-inflammatory, anti-atherogenic.
Conclusion:
Gentiana species and their constituents affect many different factors related to
vascular disease development and progression. Therefore, Gentiana-based therapeutics represent
potentially useful drugs for the management of vascular diseases.