Background:
Gentiana lutea (GL), commonly known as yellow gentian, bitter root, and
bitterwort, belongs to family Gentianaceae. GL belongs to genus Gentiana, which is a rich
natural source of iridoids, secoiridoids, xantones, flavonoids, triterpenoids, and carbohydrates.
Medicinal plants from Gentiana species have anti-oxidant, anti-inflammatory, anti-mitogenic,
anti-proliferative, and lipid-lowering effects, as well as a cardioprotective, hypotensive,
vasodilator and anti-platelet activities.
Objective:
We reviewed the recent literature related to the effects of Gentiana species, and their
active components on vascular diseases.
Methods:
Data used for this review were obtained by searching the electronic database
[PUBMED/MEDLINE 1973 - February 2020]. The primary data search terms of interest were:
Gentiana lutea, Gentienacea family, phytochemistry, vascular diseases, treatment of vascular
diseases, anti-oxidant, anti-inflammatory, anti-atherogenic.
Conclusion:
Gentiana species and their constituents affect many different factors related to
vascular disease development and progression. Therefore, Gentiana-based therapeutics represent
potentially useful drugs for the management of vascular diseases.
Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat
