Dimethylisosorbide (DMI) as a Bio-Derived Solvent for Pd-Catalyzed Cross-Coupling Reactions
Keyword(s):
Palladium-catalyzed bond-forming reactions, such as the Suzuki–Miyaura and Mizoroki–Heck reactions, are some of the most broadly utilized reactions within the chemical industry. These reactions frequently employ hazardous solvents; however, to adhere to increasing sustainability pressures and restrictions regarding the use of such solvents, alternatives are highly sought after. Here we demonstrate the utility of dimethyl isosorbide (DMI) as a bio-derived solvent in several benchmark Pd-catalyzed reactions: Suzuki–Miyaura (13 examples, 62–100% yield), Mizoroki–Heck (13 examples, 47–91% yield), and Sonogashira (12 examples, 65–98% yield).
2016 ◽
Vol 12
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pp. 2898-2905
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2020 ◽
Vol 17
(5)
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pp. 559-569
Keyword(s):
2002 ◽
Vol 74
(1)
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pp. 43-55
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Keyword(s):
2017 ◽
Vol 89
(10)
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pp. 1413-1428
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