Autoimmune hepatitis with normal IgG at diagnosis: Subtype without selective elevation of IgG but similar histological features and treatment response

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
J Hartl ◽  
G Wong ◽  
K Zachou ◽  
A Ashgar ◽  
S Pape ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Treatment Response ◽  
Histological Features

Characteristics and long-term outcome of patients with autoimmune hepatitis related to the initial treatment response

2010 ◽  
Vol 45 (4) ◽  
pp. 457-467 ◽  
Author(s):  
Mårten Werner ◽  
Sven Wallerstedt ◽  
Stefan Lindgren ◽  
Sven Almer ◽  
Einar Björnsson ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Treatment Response ◽  
Initial Treatment ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Efficacy of 7-Day and 14-Day Triple Therapy Regimens for the Eradication ofHelicobacter pylori: A Comparative Study in a Cohort of Romanian Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Stefan Sorin Arama ◽  
Catalin Tiliscan ◽  
Cristina Negoita ◽  
Alexandru Croitoru ◽  
Victoria Arama ◽  
...  
Keyword(s):  
Treatment Response ◽  
Eradication Rate ◽  
Urban Residents ◽  
Tertiary Level ◽  
Younger Patients ◽  
Level Of Education ◽  
Histological Features ◽  
Duodenal Lesions ◽  
Study Population ◽  
Gastric Biopsies

Objective. This study compared the eradication rates of ofHelicobacter pylori(HP) infection by a 7-day and 14-day anti-HP regimen.Materials and Methods. An open, randomized, prospective study was performed to evaluate the response to anti-HP treatment in adult HP-positive patients following a 7-day course (Regimen A) of a proton pump inhibitor in association with clarithromycin and amoxicillin compared to a 14-day course (Regimen B). Gastric biopsies were performed at baseline and two months after anti-HP treatment.Results. Seventy-eight patients aged 18–64 years (28 males, 50 females) diagnosed with HP infection were included. Fifty-two (66.7%) patients received Regimen B and 26 (33.3%) Regimen A. The overall eradication rate was 70.5%. Better treatment response (p<0.01) was seen in Regimen B (44/52, 84.2% versus 11/26, 42.3%). Significant improvement in histological features was seen in regimen B. There has been significant overall reduction in endoscopic aspects of gastric and duodenal lesions in both regimens. Younger patients ≤35 years had a better response to Regimen B. Better treatment response was seen in women, urban residents, and those with tertiary level of education in both groups.Conclusion. 14-day anti-HP regimen offered a significant better overall eradication of HP in study population.

scholarly journals Treatment response in patients with autoimmune hepatitis

Hepatology ◽  
2010 ◽  
Vol 52 (6) ◽  
pp. 2247-2248 ◽  
Author(s):  
Christoph Schramm ◽  
Christina Weiler-Normann ◽  
Christiane Wiegard ◽  
Stefanie Hellweg ◽  
Susanne Müller ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Treatment Response

scholarly journals Hepatic expression of programmed death-1 (PD-1) and its ligand, PD-L1, in children with autoimmune hepatitis: relation to treatment response

2019 ◽  
Vol 5 (3) ◽  
pp. 256-264 ◽  
Author(s):  
Hala Agina ◽  
Nermine Ehsan ◽  
Taghreed Abd-Elaziz ◽  
Ghada Abd-Elfatah ◽  
Eman Said ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Treatment Response ◽  
Hepatic Expression ◽  
Programmed Death ◽  
Programmed Death 1

FRI-039-Autoimmune hepatitis-related cirrhosis: The importance of treatment response and the utility of Baveno VI criteria

2019 ◽  
Vol 70 (1) ◽  
pp. e401
Author(s):  
Laura Patricia Llovet ◽  
Oswaldo Ortiz ◽  
Montserrat García-Retortillo ◽  
Raquel Vinuesa ◽  
Judith Gómez-Camarero ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Treatment Response

scholarly journals Role of Histopathology in Autoimmune Hepatitis

2015 ◽  
Vol 33 (Suppl. 2) ◽  
pp. 53-64 ◽  
Author(s):  
Dina G. Tiniakos ◽  
John G. Brain ◽  
Yvonne A. Bury
Keyword(s):  
Differential Diagnosis ◽  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Plasma Cells ◽  
Early Stage ◽  
Scoring Systems ◽  
Histological Features ◽  
Pattern Of Injury ◽  
Hepatocellular Necrosis

The diagnosis of autoimmune hepatitis (AIH) is based on a combination of biochemical, immunological and histological features and exclusion of other causes of liver disease. Typical histological features include a chronic hepatitis pattern of injury with portal inflammation and interface activity, predominance of plasma cells in the portal infiltrate, emperipolesis, and hepatocellular rosette formation. Centrilobular injury with prominent hepatocellular necrosis and mononuclear inflammation is now recognised in the histological spectrum of AIH and may represent an early stage of the disease. Liver histology plays a major role in clinical diagnostic scoring systems and is important to confirm or support the clinical diagnosis of AIH. This review focuses on the role of histopathology in AIH and highlights the contribution of histological interpretation to the diagnosis of AIH, differential diagnosis from other entities, recognition of concurrent liver disease, and identification of the so-called overlap or variant syndromes, and addresses the importance of liver biopsy in the management and prognosis of patients with AIH.

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