Krampfanfälle bei einem Hund mit akuter myeloblastischer Leukämie

2004 ◽  
Vol 32 (01) ◽  
pp. 15-20
Author(s):  
I. Kathmann ◽  
D. Ledieu ◽  
K. Allenspach ◽  
G. Fodor ◽  
A. Jaggy ◽  
...  
Keyword(s):  
Akute Leukämien ◽  
French American British

Zusammenfassung:Als Leukämie bezeichnet man eine neoplastische Wucherung von hämatopoetischen Vorläuferzellen im Knochenmark. Entsprechend der FAB-(French-American-British-) Klassifizierung beim Menschen können auch Leukämien beim Tier durch die normale Zytologie und Resultate immunhistochemischer und zytoenzymatischer Untersuchungen in weitere Gruppen unterteilt werden. Akute Leukämien kommen beim Hund selten vor. Das Auftreten von Krampfanfällen im Zusammenhang mit einer akuten myeloiden Leukämie beim Hund wurde unseres Wissens noch nie beschrieben. Es wird ein Literaturüberblick gegeben und der Fall einer vierjährigen Dalmatiner-Mischlingshündin beschrieben, die wegen epileptischer Krampfanfälle, Schwächezuständen und Inkoordination überwiesen wurde. Unter Berücksichtigung der zytologischen, zytoenzymatischen und immunhistochemischen Resultate handelte es sich um eine akute myeloblastische Leukämie (AML1 oder AML5).

Akute Leukämien

Der Onkologe ◽  
2017 ◽  
Vol 23 (7) ◽  
pp. 496-498
Author(s):  
G. Ehninger ◽  
K. Höffken
Keyword(s):  
Akute Leukämien

A new case of acute nonlymphocytic leukemia (French–American–British subtype M1) with double minutes and c-MYC amplification

2002 ◽  
Vol 132 (2) ◽  
pp. 161-164 ◽  
Author(s):  
Natàlia Rodon ◽  
Francesc Solé ◽  
Blanca Espinet ◽  
Marta Salido ◽  
Lourdes Zamora ◽  
...  
Keyword(s):  
Acute Nonlymphocytic Leukemia ◽  
Double Minutes ◽  
French American British

Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype

Blood ◽  
2005 ◽  
Vol 106 (4) ◽  
pp. 1419-1422 ◽  
Author(s):  
Giovanni Cazzaniga ◽  
Maria Grazia Dell'Oro ◽  
Cristina Mecucci ◽  
Emanuela Giarin ◽  
Riccardo Masetti ◽  
...  
Keyword(s):  
Residual Disease ◽  
Normal Karyotype ◽  
Myelogenous Leukemia ◽  
Potential Candidate ◽  
Npm1 Mutation ◽  
Reading Frame ◽  
Targeted Treatments ◽  
Acute Myelogenous ◽  
Childhood Aml ◽  
French American British

AbstractNucleophosmin (NPM) is a nucleocytoplasmic shuttling protein involved in leukemia-associated chromosomal translocations, and it regulates the alternate reading frame (ARF)-p53 tumorsuppressor pathway. Recently, it has been demonstrated that mutations of the NPM1 gene alter the protein at its C-terminal, causing its cytoplasmic localization. Cytoplasmic NPM was detected in 35% of adult patients with primary non-French-American-British (FAB) classification M3 acute myeloid leukemia (AML), associated mainly with normal karyotype. We evaluated the prevalence of the NPM1 gene mutation in non-M3 childhood AML patients enrolled in the ongoing Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP-AML02) protocol in Italy. NPM1 mutations were found in 7 (6.5%) of 107 successfully analyzed patients. NPM1- mutated patients carried a normal karyotype (7/26, 27.1%) and were older in age. Thus, the NPM1 mutation is a frequent abnormality in AML patients without known genetic marker; the mutation may represent a new target to monitor minimal residual disease in AML and a potential candidate for alternative and targeted treatments. (Blood. 2005;106:1419-1422)

Clinical Features of DIC According to the French-american-british (FAB) Classification in Patients With Acute Leukemia and Thrombomodulin Alfa Treatment – Cross-sectional Analysis of a Post-marketing Surveillance Study Cohort –

2021 ◽  
Author(s):  
Yoshinobu Seki ◽  
Goichi Honda ◽  
Noriaki Kawano ◽  
Toshimasa Uchiyama ◽  
Kazuo Kawasugi ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Clinical Features ◽  
Lymphoblastic Leukemia ◽  
Study Cohort ◽  
Cross Sectional ◽  
Safety And Efficacy ◽  
Post Marketing Surveillance ◽  
Fab Classification ◽  
Post Marketing ◽  
French American British

Abstract Background: The aims of this study were to analyze the clinical features of a large number of cases with disseminated intravascular coagulation (DIC) associated with acute leukemia, and to clarify the safety and efficacy of thrombomodulin alfa (TM-α) using the French-American-British (FAB) classification of hematological malignancies.Methods: We retrospectively examined 644 patients with acute leukemia in post-marketing surveillance for TM-α.Results: M3, M2, M4, M1, and M5 subtypes of acute myeloid leukemia (AML), and L2 and L1 subtypes of acute lymphoblastic leukemia (ALL) have been found more frequently among patients with DIC. Bleeding symptoms at baseline were more frequent in M3 and M7 subtypes. Fibrinogen concentrations were lower and plasmin-plasmin inhibitor complex values were higher in M3 and Philadelphia-positive (Ph+) ALL. Overall DIC resolution rate was 60.2% with higher rates in L1 and Ph+ ALL, lower in M1, and generally higher in ALL than in AML. The overall survival rate was 79.8%, generally high, with higher survival rates in L3, Ph+ ALL, and M3. In M3 and M7, with high frequencies of pre-existing bleeding, TM-α improved bleeding symptoms. Post-administration DIC scores in each subtype were significantly improved compared with pre-administration scores, except in M6, M7, and MDS-overt AML.Conclusions: This study showed the clinical features of DIC associated with acute leukemia among FAB classifications and also elucidated the safety and efficacy profiles of TM-α by detailed classification based on the FAB classification in clinical practice.Trial registration: The clinical characteristics and treatment outcomes of patients with DIC treated with TM-α between May 2008 and April 2010 were retrospectively analyzed by subgroup analysis of post-marketing surveillance data.

Akute Leukämien

2012 ◽  
pp. 3-29
Author(s):  
Monika Engelhardt ◽  
Dietmar Berger ◽  
Roland Mertelsmann
Keyword(s):  
Akute Leukämien

Akute Leukämien

2014 ◽  
pp. 3-34
Author(s):  
Monika Engelhardt ◽  
Dietmar Berger ◽  
Justus Duyster ◽  
Roland Mertelsmann
Keyword(s):  
Akute Leukämien

Akute Leukämien

1992 ◽  
pp. 223-282
Author(s):  
J. Drach ◽  
D. Nachbaur ◽  
P. Pohl ◽  
M. Lechleitner ◽  
C. Gattringer ◽  
...  
Keyword(s):  
Akute Leukämien

Akute Leukämien bei Kindern

Thema Krebs ◽  
1998 ◽  
pp. 28-30
Author(s):  
Hilke Stamatiadis-Smidt ◽  
Harald zur Hausen
Keyword(s):  
Akute Leukämien
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