Traumatic Exogenous Uveitis

1988 ◽  
Vol 01 (01) ◽  
pp. 35-37 ◽  
Author(s):  
B. P. Wilcock ◽  
Melanie M. Williams
Keyword(s):  
Weight Loss ◽  
Foreign Body ◽  
Ciliary Body ◽  
Foreign Body Reaction ◽  
Anterior Segment ◽  
Tissue Formation ◽  
Ocular Tissues ◽  
Granulation Tissue Formation ◽  
Orbital Muscle ◽  
Inflammatory Changes

A young dog was presented to the veterinary ophthalmology service with marked unilateral anterior uveitis and blindness, extreme pain, anorexia and weight loss. Porcupine quill migration into the orbital and ocular tissues was suspected due to an encounter with a porcupine three weeks previously. Surgical orbital extenteration and exploration revealed two porcupine quill segments penetrating the oculus bulbi and extending into the orbital tissues. The location and movement of the quills within the globe and orbital muscle cone during mastication accounted for the deep pain, anorexia and weight loss. The quills incited a sterile foreign body reaction with fibroplasia and granulation tissue formation in the sclera and ciliary body. The eye was avisual due to the anterior segment structural and inflammatory changes.

scholarly journals Fifty-Three Years after a Pencil Puncture Wound

2015 ◽  
Vol 7 (3) ◽  
pp. 303-305 ◽  
Author(s):  
Vijay H. Aswani ◽  
Seung Lae Kim
Keyword(s):  
Foreign Body ◽  
Granulation Tissue ◽  
Foreign Body Reaction ◽  
Histologic Examination ◽  
Black Pigment ◽  
Surrounding Tissue ◽  
Tissue Formation ◽  
Puncture Wound ◽  
Granulation Tissue Formation ◽  
Reparative Changes

A pencil core with an intact pencil tip was excised from the thigh of a 60-year-old male 53 years after a puncture wound. Histologic examination of the excised pencil core and the surrounding tissue revealed a foreign body reaction with abundant entrapped dark black pigment and chronic reparative changes, including dense sclerosis and focal granulation tissue formation.

Histologic Study of Homograft Cartilages Implanted in the Middle Ear

1988 ◽  
Vol 98 (6) ◽  
pp. 546-551 ◽  
Author(s):  
Etsuo Yamamoto ◽  
Michitaka Iwanaga ◽  
Manabu Fukumoto
Keyword(s):  
Foreign Body ◽  
Connective Tissue ◽  
Middle Ear ◽  
Foreign Body Reaction ◽  
Fibrous Connective Tissue ◽  
Histologic Study ◽  
Second Stage ◽  
The Matrix ◽  
Inflammatory Changes ◽  
Histologic Changes

We examined conditions of the micro-sliced homograft cartilages implanted in the middle ear, implanted cartilages removed at revision surgery or implanted cartilages removed at the second stage of staged tympanoplasty, both macroscopically and histologically. Macroscopically, the appearance and shape of the cartilages remained unchanged, with no evidence of erosion. There was no evidence of any foreign body reaction or rejection phenomenon. In general, no marked histologic changes of the matrix tissues were found, although chondrocytes showed degenerative changes. There was partial absorption of cartilage and replacement by fibrous connective tissue when inflammatory changes occurred in the middle ear. It is concluded that implanted homograft cartilage maintains its stiffness for more than 6 months in a healthy, aerated middle ear and appears to be clinically useful for tympanoplasty.

scholarly journals Airway Stenosis Related to Foreign Body Aspiration: An Under-recognized Long term Complication

2019 ◽  
Vol 12 ◽  
pp. 117954761986381 ◽  
Author(s):  
Ravindra M Mehta ◽  
Nadakuditi Rashmi ◽  
Pooja Bajaj ◽  
Shyam Krishnan ◽  
Lakshmipriya Srinivasan
Keyword(s):  
Foreign Body ◽  
Granulation Tissue ◽  
Case Series ◽  
Foreign Body Aspiration ◽  
Areca Nut ◽  
Tissue Formation ◽  
Airway Patency ◽  
Granulation Tissue Formation ◽  
Airway Stenosis

Introduction: Sequelae of chronic foreign body aspiration include occlusive granulation tissue formation, which can cause delayed fixed airway stenosis. The aim of this study is to highlight this complication, which should be diagnosed early and treated proactively. Methods: We present a case series of areca nut aspiration, an organic foreign body commonly chewed in Southeast Asia, complicated by delayed airway stenosis and examine the peculiar nature of areca nut that predisposes to this complication. Results: Long-term sequelae of areca nut aspiration are granulation tissue formation, potentially complicated by airway stenosis due to the mechanical and chemical irritant nature of areca nut. Discussion: Organic impacted foreign bodies such as areca nut can cause delayed complications of airway stenosis. Both the sharp edges of the areca nut and chemical irritation caused by alkaloids released by the nut in constant contact with the airway mucosa can predispose to this long-term complication. Early diagnosis and appropriate therapeutic interventions such as balloon bronchoplasty can help restore airway patency and prevent lung damage.

Peritoneal Inflammation after Twenty-Week Exposure to Dialysis Solution: Effect of Solution versus Catheter–Foreign Body Reaction

2010 ◽  
Vol 30 (3) ◽  
pp. 284-293 ◽  
Author(s):  
Michael F. Flessner ◽  
Kimberly Credit ◽  
Karla Richardson ◽  
Rebecca Potter ◽  
Xiaorong Li ◽  
...  
Keyword(s):  
Foreign Body ◽  
Inflammatory Markers ◽  
Foreign Body Reaction ◽  
Ethyl Pyruvate ◽  
Vascular Density ◽  
Hypertonic Solution ◽  
Adherent Cells ◽  
Peritoneal Dialysis Catheter ◽  
Peritoneal Inflammation ◽  
Inflammatory Changes

♦ BackgroundWe hypothesized that both sterile solutions and foreign body reaction to the peritoneal dialysis catheter are associated with inflammatory changes in rats exposed to hypertonic solution.♦ MethodsFour hypertonic solutions (30 – 40 mL) were injected daily via needle and syringe over 20 weeks in 4 groups of rats: 4.25% standard clinical solution (LAC), LAC plus pyridoxamine (PYR), LAC plus ethyl pyruvate (EP), and a biocompatible 4% dextrose solution (BIC). Two groups received catheters: a non-injected 4-week catheter group (C4) and a group injected for 20 weeks with the BIC solution (CI). Control animals (CON) were not injected. In the C4 group, adherent cells were separated from the catheter and examined by culture and electron microscopy to ensure that animals were bacteria free prior to exposure to solution. Animals underwent transport experiments to determine mass transfer coefficients of mannitol (MTCM) and albumin (MTCA), osmotic filtration flux (Josm), and hydrostatic pressure-driven flux (Jp). After euthanasia, tissues were examined for submesothelial thickness, vascular density, and immunohistochemistry for various cytokines.♦ ResultsThe catheter cell layer was free of bacteria and consisted of macrophages, lymphocytes, mesothelial cells, and fibroblastic cells. Marked differences in angiogenesis and submesothelial thickening were noted for the catheter groups. Transport differences were mixed: MTCMwas significantly less for the CI group and MTCAwas variable among the groups. There were no differences among groups for Josmor Jp. Inflammatory markers in the catheter-adherent cells correlated with inflammatory changes in the tissue. These data demonstrate significant changes in submesothelial thickness, angiogenesis, transport function, and inflammatory markers between animals injected with sterile solutions over 20 weeks with and without catheters.♦ ConclusionsAn indwelling catheter amplifies peritoneal inflammation from dialysis solutions through a foreign body reaction. Our data also suggest that additives to existing solutions may have limited the effect on inflammatory response to non-biocompatible solutions.

scholarly journals Bilateral Choanal Atresia and Endoscopic Surgery: A Chance for CHARGE Patients

2021 ◽  
Vol 10 (13) ◽  
pp. 2951
Author(s):  
Maria Baldovin ◽  
Diego Cazzador ◽  
Claudia Zanotti ◽  
Giuliana Frasson ◽  
Athanasios Saratziotis ◽  
...  
Keyword(s):  
Congenital Malformation ◽  
Endoscopic Surgery ◽  
Granulation Tissue ◽  
Choanal Atresia ◽  
Tissue Formation ◽  
Endoscopic Repair ◽  
Granulation Tissue Formation ◽  
Charge Association ◽  
Cohort Data

Bilateral choanal atresia (CA) is a rare congenital malformation frequently associated with other anomalies. CHARGE association is closely linked to bilateral CA. The aim of this study was to describe the outcomes of the endoscopic repair in bilateral CA, and to assess the role of postoperative nasal stenting in two cohorts of CHARGE-associated and non-syndromic CA. Thirty-nine children were retrospectively analyzed (16 patients had CHARGE-associated CA). The rate of postoperative neochoanal restenosis was 31.3% in the CHARGE population, and 47.8% in the non-syndromic CA cohort. Data on postoperative synechiae and granulation tissue formation, need for endonasal toilette and dilation procedures, and number of procedures per patient were presented. Stent positioning led to a higher number of postoperative dilation procedures per patient in the non-syndromic cohort (p = 0.018), and to a higher rate of restenosis both in the CHARGE-associated, and non-syndromic CA populations. Children with CHARGE-associated and non-syndromic bilateral CA benefitted from endonasal endoscopic CA correction. The postoperative application of an endonasal stent should be carefully evaluated.

scholarly journals Granuloma Caused by Carbon Deposition in the Dermis

2014 ◽  
Vol 2014 ◽  
pp. 1-2
Author(s):  
Rintaro Shibuya ◽  
Yuichiro Endo ◽  
Akihiro Fujisawa ◽  
Miki Tanioka ◽  
Yoshiki Miyachi
Keyword(s):  
Computed Tomography ◽  
Foreign Body ◽  
Malignant Melanoma ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Foreign Body Reaction ◽  
Carbon Deposition ◽  
Case Reports ◽  
Initial Injury ◽  
Pencil Lead

Pencil core granuloma is characterized by a delayed foreign-body reaction against retained fragments of pencil lead. Previous case reports presented pencil core granuloma resembling malignant melanoma, haemangioma, or soft tissue sarcoma. We present a case of pencil core granuloma arising from the palm 25 years after the initial injury. The patient presented a bluish nodule that had been present over 25 years before. The nodule initially measured 5 mm in diameter. However, five years before presentation, it suddenly enlarged to the size of 30 mm during six months. Computed tomography (CT) of the lesion revealed a linear radiopaque structure of 8 mm long with a mass on its distal end. Surgical resection revealed a bluish muddy mass and pencil lead. Histological examination revealed degenerative tissue with calcification surrounded by massive amounts of black granular material in the middle and lower dermis.

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