Methotrexate-associated toxicity during therapy of acute lymphoblastic leukemia in children with Down syndrome

2018 ◽  
Author(s):  
M Kroll ◽  
K Bleckmann ◽  
A Möricke ◽  
D Schewe ◽  
G Cario ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Children With Down Syndrome ◽  
Leukemia In Children

Outcome and toxicity of chemotherapy for acute lymphoblastic leukemia in children with down syndrome

2008 ◽  
Vol 52 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Niketa Shah ◽  
Ali Al-Ahmari ◽  
Arwa Al-Yamani ◽  
Lee Dupuis ◽  
Derek Stephens ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Children With Down Syndrome ◽  
Leukemia In Children

scholarly journals Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

Blood ◽  
2014 ◽  
Vol 123 (1) ◽  
pp. 70-77 ◽  
Author(s):  
Trudy D. Buitenkamp ◽  
Shai Izraeli ◽  
Martin Zimmermann ◽  
Erik Forestier ◽  
Nyla A. Heerema ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Good Prognosis ◽  
Study Group ◽  
Children With Down Syndrome ◽  
Key Points ◽  
Leukemia In Children ◽  
Treatment Related Mortality ◽  
Related Mortality

Key Points Although the risk of ALL relapse is significantly higher in children with DS, good-prognosis subgroups have been identified. Patients with DS-ALL have higher treatment-related mortality throughout the treatment period independent of the therapeutic regimen.

scholarly journals Outcome of transplantation for acute lymphoblastic leukemia in children with down syndrome

2014 ◽  
Vol 61 (6) ◽  
pp. 1126-1128 ◽  
Author(s):  
Johann K. Hitzler ◽  
Wensheng He ◽  
John Doyle ◽  
Mitchell Cairo ◽  
Bruce M. Camitta ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Children With Down Syndrome ◽  
Leukemia In Children

scholarly journals Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia

2020 ◽  
Vol 4 (4) ◽  
pp. 672-675 ◽  
Author(s):  
Peleg Winer ◽  
Ivo S. Muskens ◽  
Kyle M. Walsh ◽  
Ajay Vora ◽  
Anthony V. Moorman ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Germline Variants ◽  
Children With Down Syndrome ◽  
Key Points ◽  
Predisposition Genes ◽  
Leukemia In Children

Key Points Rare and pathogenic germline variants, including in IKZF1, contribute to acute lymphoblastic leukemia in children with Down syndrome.

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