High Risk of Acquired Immune Deficiency Syndrome (AIDS) and of AIDS Related Complex (ARC) in Hemophiliacs Seropositive for more than 5 Years

1989 ◽  
Vol 61 (03) ◽  
pp. 354-356 ◽  
Author(s):  
C Stain ◽  
I Pabinger-Fasching ◽  
K Guggenberger ◽  
U Köller ◽  
M Stain ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
High Risk ◽  
Factor Viii ◽  
Laboratory Tests ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Aids Related Complex ◽  
Acquired Immune Deficiency ◽  
Hiv 1

SummaryA group of 90 hemophiliacs who had been regularly treated with non virus-inactivated factor VIII or IX concentrates were studied in 1983. At that time 50 patients were HIV-1-antibody positive, 6 additional seroconversions occurred until 1985. 26 of the 50 patients seropositive in 1983 are currently asymptomatic. 4 patients have developed the lymphadenopathy syndroffie, 9 patients AIDS and 11 patients ARC (CDC IV C 2). 6/9 cases of AIDS and 10/11 cases of ARC have occurred only after 1985. Patients, who subsequently became symptomatic, had significantly higher IgG levels in 1983, otherwise no predictive laboratory tests were identified. Patients with T4 counts above 500/μl became symptomatic later, but after 5 years the indicence of AIDS was comparable in patients with original T4 counts of more than or below 500/μl.

scholarly journals The origin of acquired immune deficiency syndrome: Darwinian or Lamarckian?

2001 ◽  
Vol 356 (1410) ◽  
pp. 877-887 ◽  
Author(s):  
Tom Burr ◽  
J. M. Hyman ◽  
Gerald Myers
Keyword(s):  
Immune Deficiency ◽  
Simulated Data ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Darwinian Evolution ◽  
Immunodeficiency Virus ◽  
Acquired Immune Deficiency ◽  
Hiv 1

The subtypes of human immunodeficiency virus type 1 (HIV–1) group M exhibit a remarkable similarity in their between–subtype distances, which we refer to as high synchrony. The shape of the phylogenetic tree of these subtypes is referred to as a sunburst to distinguish it from a simple star phylogeny. Neither a sunburst pattern nor a comparable degree of symmetry is seen in a natural process such as in feline immunodeficiency virus evolution. We therefore have undertaken forward–process simulation studies employing coalescent theory to investigate whether such highly synchronized subtypes could be readily produced by natural Darwinian evolution. The forward model includes both classical (macro) and molecular (micro) epidemiological components. HIV–1 group M subtype synchrony is quantified using the standard deviation of the between–subtype distances and the average of the within–subtype distances. Highly synchronized subtypes and a sunburst phylogeny are not observed in our simulated data, leading to the conclusion that a quasi–Lamarckian, punctuated event occurred. The natural transfer theory for the origin of human acquired immune deficiency syndrome (AIDS) cannot easily be reconciled with these findings and it is as if a recent non–Darwinian process took place coincident with the rise of AIDS in Africa.

HIV: introduction and epidemiology

2019 ◽  
pp. 449-456
Keyword(s):  
Risk Factors ◽  
Immune Deficiency ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Background Information ◽  
Prevalence Data ◽  
Sex With Men ◽  
Acquired Immune Deficiency ◽  
Hiv 1

This chapter provides background information to the events that led to the discovery of HIV. Previously fit young men who have sex with men presented with certain infections and cancers, coupled with severe immune deficiency, which was later given the name acquired immune deficiency syndrome (AIDS). This chapter gives information about the origin of HIV and its link to simian immunodeficiency viruses (SIVs). This chapter provides information on the geographical, and the epidemiological differences between HIV-1 and HIV-2. The chapter also explains the biological implications of HIV types and subtypes. Risk factors and transmission routes are also discussed, in addition to UK and worldwide HIV prevalence data.

scholarly journals The earliest cases of human immunodeficiency virus type 1 group M in Congo-Kinshasa, Rwanda and Burundi and the origin of acquired immune deficiency syndrome

2001 ◽  
Vol 356 (1410) ◽  
pp. 923-925 ◽  
Author(s):  
Daniel Vangroenweghe
Keyword(s):  
Immune Deficiency ◽  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Immunodeficiency Virus ◽  
Acquired Immune Deficiency ◽  
Hiv 1

The early cases of acquired immune deficiency syndrome and human immunodeficiency virus type 1 (HIV–1) infection in the 1960s and 1970s in Congo–Kinshasa (Zaire), Rwanda and Burundi are reviewed. These countries appear to be the source of the HIV–1 group M epidemic, which then spread outwards to neighbouring Tanzania and Uganda in the east, and Congo–Brazzaville in the west. Further spread to Haiti and onwards to the USA can be explained by the hundreds of single men from Haiti who participated in the UNESCO educational programme in the Congo between 1960 and 1975.

Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex

1986 ◽  
Vol 108 (4) ◽  
pp. 498-503 ◽  
Author(s):  
Arye Rubinstein ◽  
Rachel Morecki ◽  
Bernard Silverman ◽  
Morris Charytan ◽  
Ben Zion Krieger ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Pulmonary Disease ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Aids Related Complex ◽  
Acquired Immune Deficiency ◽  
Related Complex

scholarly journals The origins of acquired immune deficiency syndrome viruses: where and when?

2001 ◽  
Vol 356 (1410) ◽  
pp. 867-876 ◽  
Author(s):  
Paul M. Sharp ◽  
Elizabeth Bailes ◽  
Roy R. Chaudhuri ◽  
Cynthia M. Rodenburg ◽  
Mario O. Santiago ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Sub Saharan Africa ◽  
Phylogenetic Position ◽  
Last Common Ancestor ◽  
Equatorial Africa ◽  
Acquired Immune Deficiency ◽  
Hiv 1

In the absence of direct epidemiological evidence, molecular evolutionary studies of primate lentiviruses provide the most definitive information about the origins of human immunodeficiency virus (HIV)–1 and HIV–2. Related lentiviruses have been found infecting numerous species of primates in sub–Saharan Africa. The only species naturally infected with viruses closely related to HIV–2 is the sooty mangabey ( Cercocebus atys ) from western Africa, the region where HIV–2 is known to be endemic. Similarly, the only viruses very closely related to HIV–1 have been isolated from chimpanzees ( Pan troglodytes ), and in particular those from western equatorial Africa, again coinciding with the region that appears to be the hearth of the HIV–1 pandemic. HIV–1 and HIV–2 have each arisen several times: in the case of HIV–1, the three groups (M, N and O) are the result of independent cross–species transmission events. Consistent with the phylogenetic position of a ‘fossil’ virus from 1959, molecular clock analyses using realistic models of HIV–1 sequence evolution place the last common ancestor of the M group prior to 1940, and several lines of evidence indicate that the jump from chimpanzees to humans occurred before then. Both the inferred geographical origin of HIV–1 and the timing of the cross–species transmission are inconsistent with the suggestion that oral polio vaccines, putatively contaminated with viruses from chimpanzees in eastern equatorial Africa in the late 1950s, could be responsible for the origin of acquired immune deficiency syndrome.

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